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Alox5ap
Gene Detail
Symbol

Name
ID
Alox5ap
arachidonate 5-lipoxygenase activating protein
MGI:107505
Synonyms
arachidonate 5 lipoxygenase activating protein, Flap
Feature Type
protein coding gene
Genetic Map
Chromosome 5
89.18 cM, cytoband G3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:149265058-149265182 bp, + strand
From VEGA annotation of GRCm38

  125 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1231  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ALOX5AP
Gene Tree: Alox5ap

Human
homologs
ALOX5AP, arachidonate 5-lipoxygenase-activating protein
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 241
neXtProt AC: NX_P20292

Human Synonyms: FLAP

Human Chr (Location): 13q12; chr13:30713478-30764428 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ALOX5AP

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix )
 
Targeted mutations of this gene result in a complete defect in leukotriene production, resistance to platelet-activating factor mediated anaphylaxis, and reduced acute and chronic inflammatory responses.
 
Interactions
Alox5ap interacts with 27 markers (Mir28b, Mir28c, Mir34a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (75)    Tissues (46)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 74
RT-PCR 1
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase alox5ap ; ZFIN alox5ap    NEW 
Molecular
reagents
All nucleic(26) Genomic(1) cDNA(23) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000028828 (Evidence)
Ensembl Gene Model ENSMUSG00000060063 (Evidence)
Entrez Gene 11690 (Evidence)
UniGene 19844
DFCI TC1582063
DoTS DT.530361, DT.94295765, DT.101708295
NIA Mouse Gene Index U080384
Consensus CDS Project CCDS39407.1
International Mouse Phenotyping Consortium Status Alox5ap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028828 VEGA Gene Model | MGI Sequence Detail 125 C57BL/6J ±  kb
transcript OTTMUST00000071392 VEGA | MGI Sequence Detail 125 Not Applicable 
polypeptide OTTMUSP00000036577 VEGA | MGI Sequence Detail 23 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(191 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001446 5-lipoxygenase-activating protein
InterPro IPR018295 FLAP/GST2/LTC4S, conserved site
InterPro IPR023352 Membrane associated eicosanoid/glutathione metabolism-like domain
InterPro IPR001129 Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
Protein Ontology PR:000003962 arachidonate 5-lipoxygenase-activating protein
References
(Earliest) J:46832 Vickers PJ, et al., Cross-species comparison of 5-lipoxygenase-activating protein. Mol Pharmacol. 1992 Dec;42(6):1014-9
(Latest) J:212865 Yu Z, et al., Myeloid cell 5-lipoxygenase activating protein modulates the response to vascular injury. Circ Res. 2013 Feb 1;112(3):432-40
All references(40)
Other
accession IDs
MGD-MRK-36075

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory