Alox5ap
Gene Detail

Symbol Name ID

Alox5ap arachidonate 5-lipoxygenase activating protein MGI:107505

Synonyms

arachidonate 5 lipoxygenase activating protein, Flap

Feature Type

protein coding gene

Genetic Map

Chromosome 5

89.18 cM, cytoband G3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:149265058-149265182 bp, + strand From VEGA annotation of GRCm38   125 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1231  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Alox5ap

Human homologs

Human Homolog		ALOX5AP, arachidonate 5-lipoxygenase-activating protein
NCBI Gene ID		241
neXtProt AC		NX_P20292
Human Synonyms		FLAP
Human Chr (Location)		13q12; chr13:31287615-31338565 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ALOX5AP

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Targeted mutations of this gene result in a complete defect in leukotriene production, resistance to platelet-activating factor mediated anaphylaxis, and reduced acute and chronic inflammatory responses.

 

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	cellular response to calcium ion, leukotriene biosynthetic process, ...
Component	cytosol, endoplasmic reticulum, ...
Function	arachidonate 5-lipoxygenase activity, arachidonic acid binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (47)    Tissues (17)    Images (22)
Theiler Stages: 19, 23, 25, 26, 28

Assay Type	Results
RNA in situ	46
RT-PCR	1

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(25) Genomic(1) cDNA(22) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000028828 (Evidence)
Ensembl Gene Model	ENSMUSG00000060063 (Evidence)
Entrez Gene	11690 (Evidence)
UniGene	19844
DFCI	TC1582063
DoTS	DT.101708295, DT.530361, DT.94295765
NIA Mouse Gene Index	U080384
Consensus CDS Project	CCDS39407.1
International Mouse Knockout Project Status	Alox5ap

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028828	VEGA Gene Model | MGI Sequence Detail	125	C57BL/6J
transcript	OTTMUST00000071392	VEGA | MGI Sequence Detail	125	Not Applicable
polypeptide	OTTMUSP00000036577	VEGA | MGI Sequence Detail	23	Not Applicable

All sequences(24) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(121 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001446	5-lipoxygenase-activating protein
InterPro	IPR018295	FLAP/GST2/LTC4S, conserved site
InterPro	IPR023352	Membrane associated eicosanoid/glutathione metabolism-like domain
InterPro	IPR001129	Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
Protein Ontology	PR:000003962	arachidonate 5-lipoxygenase-activating protein

References

(Earliest) J:46832 Vickers PJ, et al., Cross-species comparison of 5-lipoxygenase-activating protein. Mol Pharmacol. 1992 Dec;42(6):1014-9
(Latest) J:183843 Yu Z, et al., Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6727-32
All references(39)

Other accession IDs

MGD-MRK-36075