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Alox5ap Gene Detail
Summary
  • Symbol
    Alox5ap
  • Name
    arachidonate 5-lipoxygenase activating protein
  • Synonyms
    arachidonate 5 lipoxygenase activating protein, Flap
  • Feature Type
    protein coding gene
  • IDs
    MGI:107505
    NCBI Gene: 11690
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:149265004-149288153 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 89.18 cM, cytoband G3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    198 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107505
protein coding gene Chr5:149264767-149288153 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030401
protein coding gene Chr5:155080294-155108937 (+)
A/J MGP_AJ_G0030374
protein coding gene Chr5:148475849-148499136 (+)
AKR/J MGP_AKRJ_G0030301
protein coding gene Chr5:153058884-153083362 (+)
BALB/cJ MGP_BALBcJ_G0030383
protein coding gene Chr5:149720636-149745641 (+)
C3H/HeJ MGP_C3HHeJ_G0030097
protein coding gene Chr5:154045566-154069140 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030838
protein coding gene Chr5:160783083-160811802 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028051
protein coding gene Chr5:142823318-142847120 (+)
CAST/EiJ MGP_CASTEiJ_G0029499
protein coding gene Chr5:153649622-153685878 (+)
CBA/J MGP_CBAJ_G0030075
protein coding gene Chr5:167522098-167552191 (+)
DBA/2J MGP_DBA2J_G0030219
protein coding gene Chr5:148128130-148151953 (+)
FVB/NJ MGP_FVBNJ_G0030173
protein coding gene Chr5:147374420-147404635 (+)
LP/J MGP_LPJ_G0030306
protein coding gene Chr5:155771376-155802863 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030209
protein coding gene Chr5:169664309-169689188 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030868
protein coding gene Chr5:152978708-153008303 (+)
PWK/PhJ MGP_PWKPhJ_G0029213
protein coding gene Chr5:147282639-147308831 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029049
protein coding gene Chr5:150284183-150311608 (+)
WSB/EiJ MGP_WSBEiJ_G0029576
protein coding gene Chr5:153795856-153821006 (+)



Homology
more
  • Human Ortholog
    ALOX5AP, arachidonate 5-lipoxygenase activating protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ALOX5AP, arachidonate 5-lipoxygenase activating protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FLAP
  • Links
    NCBI Gene ID: 241
    neXtProt AC: NX_P20292
    UniProt: P20292

  • Chr Location
    13q12.3; chr13:30713478-30764428 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted mutations of this gene result in a complete defect in leukotriene production, resistance to platelet-activating factor mediated anaphylaxis, and reduced acute and chronic inflammatory responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11690 NCBI Gene Model | MGI Sequence Detail 23150 C57BL/6J ±  kb
    transcript NM_009663 RefSeq | MGI Sequence Detail 1031 C57BL/6  
    polypeptide P30355 UniProt | EBI | MGI Sequence Detail 161 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR001446 5-lipoxygenase-activating protein
      IPR018295 FLAP/GST2/LTC4S, conserved site
      IPR023352 Membrane associated eicosanoid/glutathione metabolism-like domain superfamily
      IPR001129 Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 1
      cDNA 24
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36075
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 7
    • Earliest
      J:46832 Vickers PJ, et al., Cross-species comparison of 5-lipoxygenase-activating protein. Mol Pharmacol. 1992 Dec;42(6):1014-9
    • Latest
      J:255349 Rauch F, et al., Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice. Bone. 2018 Feb;107:131-142

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory