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Alox5ap
Gene Detail
 Symbol
Name
ID
Alox5ap
arachidonate 5-lipoxygenase activating protein
MGI:107505
Synonyms arachidonate 5 lipoxygenase activating protein, Flap
Feature Type protein coding gene
Genetic Map
Chromosome 5
89.18 cM, cytoband G3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:149265058-149265182 bp, + strand
From VEGA annotation of GRCm38

  125 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1231  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Alox5ap

Human
homologs
Human Homolog ALOX5AP, arachidonate 5-lipoxygenase-activating protein
NCBI Gene ID 241
neXtProt AC  NX_P20292
Human Synonyms  FLAP
Human Chr (Location)  13q12; chr13:30713478-30764428 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ALOX5AP
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
 
Targeted mutations of this gene result in a complete defect in leukotriene production, resistance to platelet-activating factor mediated anaphylaxis, and reduced acute and chronic inflammatory responses.
 
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cellular response to calcium ion, leukotriene biosynthetic process, ...
Component cytosol, endoplasmic reticulum, ...
Function arachidonate 5-lipoxygenase activity, arachidonic acid binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (75)    Tissues (45)    Images (24)
Theiler Stages: 19, 23, 25, 26, 28
Assay TypeResults
RNA in situ 74
RT-PCR 1
cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(26) Genomic(1) cDNA(23) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000028828 (Evidence)
Ensembl Gene ModelENSMUSG00000060063 (Evidence)
Entrez Gene11690 (Evidence)
UniGene19844
DFCITC1582063
DoTSDT.101708295, DT.530361, DT.94295765
NIA Mouse Gene IndexU080384
Consensus CDS ProjectCCDS39407.1
International Mouse Knockout Project StatusAlox5ap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028828 VEGA Gene Model | MGI Sequence Detail 125 C57BL/6J ±  kb
transcript OTTMUST00000071392 VEGA | MGI Sequence Detail 125 Not Applicable 
polypeptide OTTMUSP00000036577 VEGA | MGI Sequence Detail 23 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(191 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001446 5-lipoxygenase-activating protein
InterPro IPR018295 FLAP/GST2/LTC4S, conserved site
InterPro IPR023352 Membrane associated eicosanoid/glutathione metabolism-like domain
InterPro IPR001129 Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
Protein Ontology PR:000003962 arachidonate 5-lipoxygenase-activating protein
References (Earliest) J:46832 Vickers PJ, et al., Cross-species comparison of 5-lipoxygenase-activating protein. Mol Pharmacol. 1992 Dec;42(6):1014-9
(Latest) J:183843 Yu Z, et al., Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6727-32
All references(40)
Other
accession IDs
MGD-MRK-36075

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory