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Gip Gene Detail
Summary
  • Symbol
    Gip
  • Name
    gastric inhibitory polypeptide
  • Synonyms
    glucose-dependent insulinotropic polypeptide
  • Feature Type
    protein coding gene
  • IDs
    MGI:107504
    NCBI Gene: 14607
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:96024545-96030831 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 59.21 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    88 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107504
protein coding gene Chr11:96024532-96030850 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018994
protein coding gene Chr11:98298805-98306102 (+)
A/J MGP_AJ_G0018962
protein coding gene Chr11:94301918-94308107 (+)
AKR/J MGP_AKRJ_G0018932
protein coding gene Chr11:97208350-97214649 (+)
BALB/cJ MGP_BALBcJ_G0018935
protein coding gene Chr11:94786989-94793229 (+)
C3H/HeJ MGP_C3HHeJ_G0018749
protein coding gene Chr11:97350444-97356633 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019387
protein coding gene Chr11:101366685-101372930 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017017
protein coding gene Chr11:91789516-91795475 (+)
CAST/EiJ MGP_CASTEiJ_G0018303
protein coding gene Chr11:98162754-98170684 (+)
CBA/J MGP_CBAJ_G0018720
protein coding gene Chr11:105521959-105528148 (+)
DBA/2J MGP_DBA2J_G0018828
protein coding gene Chr11:93873801-93880467 (+)
FVB/NJ MGP_FVBNJ_G0018817
protein coding gene Chr11:93348904-93355139 (+)
LP/J MGP_LPJ_G0018898
protein coding gene Chr11:98848172-98856066 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018844
protein coding gene Chr11:105519135-105525263 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019427
protein coding gene Chr11:97502133-97513061 (+)
PWK/PhJ MGP_PWKPhJ_G0018074
protein coding gene Chr11:94816708-94822935 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017863
protein coding gene Chr11:97213077-97219343 (+)
WSB/EiJ MGP_WSBEiJ_G0018352
protein coding gene Chr11:97406141-97414370 (+)



Homology
more
  • Human Ortholog
    GIP, gastric inhibitory polypeptide
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GIP, gastric inhibitory polypeptide
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 2695
    neXtProt AC: NX_P09681
    UniProt: P09681

  • Chr Location
    17q21.32; chr17:48958556-48968593 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Mice homozygous for a knock-out allele exhibit obesity and insulin hypersecretion but normal K-cell number when fed a high fat diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000014351 Ensembl Gene Model | MGI Sequence Detail 6287 C57BL/6J ±  kb
transcript ENSMUST00000103157 Ensembl | MGI Sequence Detail 652 Not Applicable  
polypeptide ENSMUSP00000099446 Ensembl | MGI Sequence Detail 144 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 9
    cDNA 10
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-36074
References
more
  • Summaries
    All 81
    Developmental Gene Expression 14
    Gene Ontology 5
    Phenotypes 19
  • Earliest
    J:34800 Schieldrop PJ, et al., Isolation of a murine glucose-dependent insulinotropic polypeptide (GIP) cDNA from a tumor cell line (STC6-14) and quantification of glucose-induced increases in GIP mRNA. Biochim Biophys Acta. 1996 Aug 14;1308(2):111-3
  • Latest
    J:262188 Maekawa R, et al., Glucose-dependent insulinotropic polypeptide is required for moderate high-fat diet- but not high-carbohydrate diet-induced weight gain. Am J Physiol Endocrinol Metab. 2018 Jun 1;314(6):E572-E583

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory