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Prol1 Gene Detail
Summary
  • Symbol
    Prol1
  • Name
    proline rich, lacrimal 1
  • Synonyms
    Muc10
  • Feature Type
    protein coding gene
  • IDs
    MGI:107496
    NCBI Gene: 17830
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:88317312-88328814 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 43.56 cM, cytoband E2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    54 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107496
protein coding gene Chr5:88317312-88328817 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029704
protein coding gene Chr5:89323454-89336645 (+)
A/J MGP_AJ_G0029670
protein coding gene Chr5:85769176-85781242 (+)
AKR/J MGP_AKRJ_G0029616
protein coding gene Chr5:88615703-88627058 (+)
BALB/cJ MGP_BALBcJ_G0029680
protein coding gene Chr5:86675444-86693920 (+)
C3H/HeJ MGP_C3HHeJ_G0029403
protein coding gene Chr5:88960096-88972408 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030134
protein coding gene Chr5:92973230-92974322 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0028813
protein coding gene Chr5:88373908-88386593 (+)
CBA/J MGP_CBAJ_G0029372
protein coding gene Chr5:96026461-96038827 (+)
DBA/2J MGP_DBA2J_G0029517
protein coding gene Chr5:85857460-85868725 (+)
FVB/NJ MGP_FVBNJ_G0029476
protein coding gene Chr5:84790121-84802700 (+)
LP/J MGP_LPJ_G0029605
protein coding gene Chr5:89715449-89727340 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029505
protein coding gene Chr5:101064221-101077429 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030168
protein coding gene Chr5:88136543-88151855 (+)
PWK/PhJ MGP_PWKPhJ_G0028532
protein coding gene Chr5:84915172-84927995 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028367
protein coding gene Chr5:87588773-87600637 (+)
WSB/EiJ MGP_WSBEiJ_G0028892
protein coding gene Chr5:88532994-88546750 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    4 involving Prol1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000064156 Ensembl Gene Model | MGI Sequence Detail 11503 C57BL/6J ±  kb
transcript ENSMUST00000170832 Ensembl | MGI Sequence Detail 1163 Not Applicable  
polypeptide ENSMUSP00000132678 Ensembl | MGI Sequence Detail 312 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
Molecular
Reagents
less
  • All nucleic 132
    cDNA 132

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-36064
References
more
  • Summaries
    All 32
    Developmental Gene Expression 7
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:285242 Peluso G, et al., Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome. J Biol Chem. 2020 Jan 31;295(5):1411-1425

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory