Myl7 MGI Mouse Gene Detail - MGI:107495 - myosin, light polypeptide 7, regulatory

Myl7 Gene Detail

Symbol

Myl7
Name

myosin, light polypeptide 7, regulatory
Synonyms

MLC2a, MLC-2alpha, Mylc2a, RLC-A

Feature Type

protein coding gene
IDs

MGI:107495
NCBI Gene: 17898
Gene Overview

MyGene.info: MYL7

Sequence Map

Chr11:5896637-5898782 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

2146 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 3.88 cM
Mapping Data

1 experiment

Human Ortholog

MYL7, myosin light chain 7

Vertebrate Orthologs

7

Human Ortholog

MYL7, myosin light chain 7
Orthology source: HomoloGene, HGNC
Synonyms

MYL2A, MYLC2A
Links

HGNC:21719

NCBI Gene ID: 58498

neXtProt AC: NX_Q01449
Chr Location

7p21-p11.2; chr7:44138864-44141388 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 23290
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 zebrafish
HCOP

human homology predictions: MYL7
Gene Tree

Myl7

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Phenotype Summary

20 phenotypes from 1 allele in 1 genetic background
4 phenotypes from multigenic genotypes
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

1
Targeted

1

Embryos homozygous for a knock-in allele show lack of atrial myofibrillar organization, atrial malfunction, aberrant cardiac chamber and looping morphogenesis, defects in yolk sac and intraembryonic vasculature, growth arrest, pericardial edema, and death at E10.5-E11.5.

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All GO Annotations

6
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

204
Tissues

62
cDNA Data

10
Literature Summary

120

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase myl7

ZFIN myl7

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Myl7 interacts with 3 markers (Mir325, Mir346, Mir3082) View All

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All Sequences

20
RefSeq

2
UniProt

2
CCDS

CCDS24408.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000005104	VEGA Gene Model \| MGI Sequence Detail	2146	C57BL/6J	± kb
transcript	OTTMUST00000011416	VEGA \| MGI Sequence Detail	590	Not Applicable
polypeptide	OTTMUSP00000005318	VEGA \| MGI Sequence Detail	175	Not Applicable

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SNPs within 2kb

14 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000010840 myosin regulatory light chain 2, atrial isoform
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

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All nucleic 20

cDNA 11

Primer pair 1

Other 8

Microarray probesets 4

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MGD-MRK-36063

Summaries

All 153

Developmental Gene Expression 120

Gene Ontology 4

Phenotypes 7
Earliest

J:35864 Lowey S, et al., Light chains from fast and slow muscle myosins. Nature. 1971 Nov 12;234(5324):81-5
Latest

J:231312 Baardman ME, et al., Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development. Dis Model Mech. 2016 Apr 1;9(4):413-25

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/20/2016 MGI 6.05