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Myl7
Gene Detail
Symbol

Name
ID
Myl7
myosin, light polypeptide 7, regulatory
MGI:107495
Synonyms
MLC2a, MLC-2alpha, Mylc2a, RLC-A
Feature Type
protein coding gene
Genetic Map
Chromosome 11
3.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:5896637-5898782 bp, - strand
From VEGA annotation of GRCm38

  2146 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23290  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 zebrafish

Gene Tree: Myl7

Human
homologs
Human Homolog MYL7, myosin, light chain 7, regulatory
NCBI Gene ID 58498
neXtProt AC  NX_Q01449
Human Synonyms  MYL2A, MYLC2A
Human Chr (Location)  7p21-p11.2; chr7:44138864-44141317 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
 
Embryos homozygous for a knock-in allele show lack of atrial myofibrillar organization, atrial malfunction, aberrant cardiac chamber and looping morphogenesis, defects in yolk sac and intraembryonic vasculature, growth arrest, pericardial edema, and death at E10.5-E11.5.
 
Interactions
Myl7 interacts with 3 markers (Mir325, Mir346, Mir3082)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Component A band, dendritic spine, ...
Function calcium ion binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (110 records)
Data Summary: Results (196)    Tissues (59)    Images (131)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 67
RNA in situ 94
Northern blot 6
Western blot 8
RT-PCR 14
RNase protection 7
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(11) Primer pair(1) Other(7)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005104 (Evidence)
Ensembl Gene ModelENSMUSG00000020469 (Evidence)
Entrez Gene17898 (Evidence)
DFCITC1579480
DoTSDT.493265, DT.94356460
NIA Mouse Gene IndexU032477
Consensus CDS ProjectCCDS24408.1
International Mouse Knockout Project StatusMyl7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005104 VEGA Gene Model | MGI Sequence Detail 2146 C57BL/6J ±  kb
transcript OTTMUST00000011416 VEGA | MGI Sequence Detail 590 Not Applicable 
polypeptide OTTMUSP00000005318 VEGA | MGI Sequence Detail 175 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(14 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
Protein Ontology PR:000010840 myosin regulatory light chain 2, atrial isoform
References
(Earliest) J:35864 Lowey S, et al., Light chains from fast and slow muscle myosins. Nature. 1971 Nov 12;234(5324):81-5
(Latest) J:204523 Udan RS, et al., Dynamic responses of endothelial cells to changes in blood flow during vascular remodeling of the mouse yolk sac. Development. 2013 Oct;140(19):4041-50
All references(146)
Other
accession IDs
MGD-MRK-36063

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory