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Myl7 Gene Detail
Summary
  • Symbol
    Myl7
  • Name
    myosin, light polypeptide 7, regulatory
  • Synonyms
    MLC2a, MLC-2alpha, Mylc2a, RLC-A
  • Feature Type
    protein coding gene
  • IDs
    MGI:107495
    NCBI Gene: 17898
  • Gene Overview
    MyGene.info: MYL7
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:5846637-5848782 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 3.88 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    9 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107495
 protein coding gene Chr11:5846637-5848782 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018011
 protein coding gene Chr11:2983383-2985527 (-)
A/J MGP_AJ_G0017984
 protein coding gene Chr11:2866531-2868675 (-)
AKR/J MGP_AKRJ_G0017948
 protein coding gene Chr11:3015910-3018054 (-)
BALB/cJ MGP_BALBcJ_G0017952
 protein coding gene Chr11:2858909-2861053 (-)
C3H/HeJ MGP_C3HHeJ_G0017765
 protein coding gene Chr11:2889668-2891813 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018404
 protein coding gene Chr11:3066789-3068934 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016062
 protein coding gene Chr11:2766739-2768879 (-)
CAST/EiJ MGP_CASTEiJ_G0017327
 protein coding gene Chr11:2858862-2860806 (-)
CBA/J MGP_CBAJ_G0017740
 protein coding gene Chr11:3436670-3438815 (-)
DBA/2J MGP_DBA2J_G0017850
 protein coding gene Chr11:2772918-2775063 (-)
FVB/NJ MGP_FVBNJ_G0017842
 protein coding gene Chr11:2802140-2804282 (-)
LP/J MGP_LPJ_G0017921
 protein coding gene Chr11:3062859-3065003 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017868
 protein coding gene Chr11:3034071-3036215 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018444
 protein coding gene Chr11:3021940-3024082 (-)
PWK/PhJ MGP_PWKPhJ_G0017107
 protein coding gene Chr11:2798049-2800191 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016904
 protein coding gene Chr11:2988314-2990465 (-)
WSB/EiJ MGP_WSBEiJ_G0017381
 protein coding gene Chr11:2862577-2864721 (-)



Homology
more
  • Human Ortholog
    MYL7, myosin light chain 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYL7, myosin light chain 7
  • Synonyms
    MYL2A, MYLC2A
  • Links
    NCBI Gene ID: 58498
    neXtProt AC: NX_Q01449
    UniProt: Q01449

  • Chr Location
    7p13; chr7:44138864-44141392 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-in allele show lack of atrial myofibrillar organization, atrial malfunction, aberrant cardiac chamber and looping morphogenesis, defects in yolk sac and intraembryonic vasculature, growth arrest, pericardial edema, and death at E10.5-E11.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1005
  • Tissues
    108
  • cDNA Data
    11
  • Literature Summary
    138
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17898 NCBI Gene Model | MGI Sequence Detail 2146 C57BL/6J ±  kb
    transcript NM_022879 RefSeq | MGI Sequence Detail 599 C57BL/6  
    polypeptide Q9QVP4 UniProt | EBI | MGI Sequence Detail 175 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 13
      Primer pair 2
      Other 12

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36063
    References
    more
    • Summaries
      All 180
      Developmental Gene Expression 138
      Gene Ontology 5
      Phenotypes 14
    • Earliest
      J:35864 Lowey S, et al., Light chains from fast and slow muscle myosins. Nature. 1971 Nov 12;234(5324):81-5
    • Latest
      J:312468 Jorgensen R, et al., Deletion of Sphingosine 1-Phosphate receptor 1 in cardiomyocytes during development leads to abnormal ventricular conduction and fibrosis. Physiol Rep. 2021 Oct;9(19):e15060
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/23/2021
    MGI 6.17     		The Jackson Laboratory