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Myl7 Gene Detail
Summary
  • Symbol
    Myl7
  • Name
    myosin, light polypeptide 7, regulatory
  • Synonyms
    MLC2a, MLC-2alpha, Mylc2a, RLC-A
  • Feature Type
    protein coding gene
  • IDs
    MGI:107495
    NCBI Gene: 17898
  • Gene Overview
    MyGene.info: MYL7
Location & Maps
more
  • Genetic Map
    Chromosome 11, 3.88 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MYL7, myosin light chain 7
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MYL7, myosin light chain 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MYL2A, MYLC2A
  • Links
    NCBI Gene ID: 58498
    neXtProt AC: NX_Q01449

  • Chr Location
    7p21-p11.2; chr7:44138864-44141388 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    1
  • Targeted
    1
Embryos homozygous for a knock-in allele show lack of atrial myofibrillar organization, atrial malfunction, aberrant cardiac chamber and looping morphogenesis, defects in yolk sac and intraembryonic vasculature, growth arrest, pericardial edema, and death at E10.5-E11.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005104 VEGA Gene Model | MGI Sequence Detail 2146 C57BL/6J ±  kb
transcript OTTMUST00000011416 VEGA | MGI Sequence Detail 590 Not Applicable  
polypeptide OTTMUSP00000005318 VEGA | MGI Sequence Detail 175 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    14 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010840 myosin regulatory light chain 2, atrial isoform
  • InterPro Domains
    IPR018247 EF-Hand 1, calcium-binding site
    IPR002048 EF-hand domain
    IPR011992 EF-hand domain pair
Molecular
Reagents
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  • All nucleic 20
    cDNA 11
    Primer pair 1
    Other 8

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-36063
References
more
  • Summaries
    All 153
    Developmental Gene Expression 120
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:35864 Lowey S, et al., Light chains from fast and slow muscle myosins. Nature. 1971 Nov 12;234(5324):81-5
  • Latest
    J:231312 Baardman ME, et al., Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development. Dis Model Mech. 2016 Apr 1;9(4):413-25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory