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Myl7
Gene Detail
Symbol

Name
ID
Myl7
myosin, light polypeptide 7, regulatory
MGI:107495
Synonyms
MLC2a, MLC-2alpha, Mylc2a, RLC-A
Feature Type
protein coding gene
Genetic Map
Chromosome 11
3.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:5896637-5898782 bp, - strand
From VEGA annotation of GRCm38

  2146 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23290  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 zebrafish

HCOP human homology predictions: MYL7
Gene Tree: Myl7

Human
homologs
MYL7, myosin, light chain 7, regulatory
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 58498
neXtProt AC: NX_Q01449

Human Synonyms: MYL2A, MYLC2A

Human Chr (Location): 7p21-p11.2; chr7:44138864-44141388 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
 
Embryos homozygous for a knock-in allele show lack of atrial myofibrillar organization, atrial malfunction, aberrant cardiac chamber and looping morphogenesis, defects in yolk sac and intraembryonic vasculature, growth arrest, pericardial edema, and death at E10.5-E11.5.
 
Interactions
Myl7 interacts with 3 markers (Mir325, Mir346, Mir3082)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Component A band, dendritic spine, ...
Function calcium ion binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (116 records)
Data Summary: Results (203)    Tissues (62)    Images (135)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 74
RNA in situ 94
Northern blot 6
Western blot 8
RT-PCR 14
RNase protection 7
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase myl7 ; ZFIN myl7    NEW 
Molecular
reagents
All nucleic(19) cDNA(11) Primer pair(1) Other(7)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000005104 (Evidence)
Ensembl Gene Model ENSMUSG00000020469 (Evidence)
Entrez Gene 17898 (Evidence)
DFCI TC1579480
DoTS DT.493265, DT.94356460
NIA Mouse Gene Index U032477
Consensus CDS Project CCDS24408.1
International Mouse Phenotyping Consortium Status Myl7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005104 VEGA Gene Model | MGI Sequence Detail 2146 C57BL/6J ±  kb
transcript OTTMUST00000011416 VEGA | MGI Sequence Detail 590 Not Applicable 
polypeptide OTTMUSP00000005318 VEGA | MGI Sequence Detail 175 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(14 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand domain pair
Protein Ontology PR:000010840 myosin regulatory light chain 2, atrial isoform
References
(Earliest) J:35864 Lowey S, et al., Light chains from fast and slow muscle myosins. Nature. 1971 Nov 12;234(5324):81-5
(Latest) J:217173 Lockhart MM, et al., Alk3 mediated Bmp signaling controls the contribution of epicardially derived cells to the tissues of the atrioventricular junction. Dev Biol. 2014 Dec 1;396(1):8-18
All references(151)
Other
accession IDs
MGD-MRK-36063

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory