Myl7 MGI Mouse Gene Detail - MGI:107495 - myosin, light polypeptide 7, regulatory

Symbol

Myl7
Name

myosin, light polypeptide 7, regulatory
Synonyms

MLC2a, MLC-2alpha, Mylc2a, RLC-A

Feature Type

protein coding gene
IDs

MGI:107495
NCBI Gene: 17898
Gene Overview

MyGene.info: MYL7
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:5896637-5898782 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 3.88 cM
Mapping Data

1 experiment

SNPs within 2kb

14 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107495	protein coding gene	Chr11:5896637-5898782 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018011	protein coding gene	Chr11:2983383-2985527 (-)
A/J	MGP_AJ_G0017984	protein coding gene	Chr11:2866531-2868675 (-)
AKR/J	MGP_AKRJ_G0017948	protein coding gene	Chr11:3015910-3018054 (-)
BALB/cJ	MGP_BALBcJ_G0017952	protein coding gene	Chr11:2858909-2861053 (-)
C3H/HeJ	MGP_C3HHeJ_G0017765	protein coding gene	Chr11:2889668-2891813 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018404	protein coding gene	Chr11:3066789-3068934 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016062	protein coding gene	Chr11:2766739-2768879 (-)
CAST/EiJ	MGP_CASTEiJ_G0017327	protein coding gene	Chr11:2858862-2860806 (-)
CBA/J	MGP_CBAJ_G0017740	protein coding gene	Chr11:3436670-3438815 (-)
DBA/2J	MGP_DBA2J_G0017850	protein coding gene	Chr11:2772918-2775063 (-)
FVB/NJ	MGP_FVBNJ_G0017842	protein coding gene	Chr11:2802140-2804282 (-)
LP/J	MGP_LPJ_G0017921	protein coding gene	Chr11:3062859-3065003 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017868	protein coding gene	Chr11:3034071-3036215 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018444	protein coding gene	Chr11:3021940-3024082 (-)
PWK/PhJ	MGP_PWKPhJ_G0017107	protein coding gene	Chr11:2798049-2800191 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016904	protein coding gene	Chr11:2988314-2990465 (-)
WSB/EiJ	MGP_WSBEiJ_G0017381	protein coding gene	Chr11:2862577-2864721 (-)

Human Ortholog

MYL7, myosin light chain 7

Vertebrate Orthologs

7

Human Ortholog

MYL7, myosin light chain 7
Orthology source: HomoloGene, HGNC
Synonyms

MYL2A, MYLC2A
Links

HGNC:21719

NCBI Gene ID: 58498

neXtProt AC: NX_Q01449

UniProt: Q01449
Chr Location

7p13; chr7:44138864-44141392 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 23290
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: MYL7
Gene Tree

Myl7

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Phenotype Summary

20 phenotypes from 1 allele in 1 genetic background
4 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

1
Targeted

1
Find Mice (IMSR)

5 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Embryos homozygous for a knock-in allele show lack of atrial myofibrillar organization, atrial malfunction, aberrant cardiac chamber and looping morphogenesis, defects in yolk sac and intraembryonic vasculature, growth arrest, pericardial edema, and death at E10.5-E11.5.

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All GO Annotations

6
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

267
Tissues

79
cDNA Data

11
Literature Summary

129

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase myl7

ZFIN myl7

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Myl7 interacts with 3 markers (Mir325, Mir346, Mir3082) View All

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All Sequences

35
RefSeq

2
UniProt

2
CCDS

CCDS24408.1

Ensembl

ENSMUSG00000020469 (Evidence)
NCBI Gene

17898

			Length	Strain/Species	Flank
genomic	17898	NCBI Gene Model \| MGI Sequence Detail	2146	C57BL/6J	± kb
transcript	NM_022879	RefSeq \| MGI Sequence Detail	599	C57BL/6
polypeptide	Q9QVP4	UniProt \| EBI \| MGI Sequence Detail	175	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

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All nucleic 23

cDNA 12

Primer pair 1

Other 10

Microarray probesets 4

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MGD-MRK-36063

Summaries

All 167

Developmental Gene Expression 129

Gene Ontology 4

Phenotypes 12
Earliest

J:35864 Lowey S, et al., Light chains from fast and slow muscle myosins. Nature. 1971 Nov 12;234(5324):81-5
Latest

J:265824 Hoog TG, et al., The effects of reduced hemodynamic loading on morphogenesis of the mouse embryonic heart. Dev Biol. 2018 Oct 1;442(1):127-137

TSS for Myl7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106663	Chr11:5898771-5898788 (-)	2 bp
Tssr106662	Chr11:5898617-5898632 (-)	157 bp
Tssr106661	Chr11:5898560-5898574 (-)	215 bp
Tssr106660	Chr11:5898528-5898541 (-)	247 bp
Tssr106659	Chr11:5898010-5898043 (-)	755 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/08/2019 MGI 6.13