Myl7
Gene Detail

Symbol Name ID

Myl7 myosin, light polypeptide 7, regulatory MGI:107495

Synonyms

MLC2a, MLC-2alpha, Mylc2a, RLC-A

Feature Type

protein coding gene

Genetic Map

Chromosome 11

3.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:5896637-5898782 bp, - strand From VEGA annotation of GRCm38   2146 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:23290  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 zebrafish

Gene Tree: Myl7

Human homologs

Human Homolog		MYL7, myosin, light chain 7, regulatory
NCBI Gene ID		58498
neXtProt AC		NX_Q01449
Human Synonyms		MYL2A, MYLC2A
Human Chr (Location)		7p21-p11.2; chr7:44178463-44180916 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Embryos homozygous for a knock-in allele show lack of atrial myofibrillar organization, atrial malfunction, aberrant cardiac chamber and looping morphogenesis, defects in yolk sac and intraembryonic vasculature, growth arrest, pericardial edema, and death at E10.5-E11.5.

 

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Component	A band, dendritic spine, ...
Function	calcium ion binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (107 records)
Data Summary: Results (121)    Tissues (47)    Images (68)
Theiler Stages: 12, 13, 14, 15, 16, 17, 18, 20, 21, 22, 23, 24, 28

Assay Type	Results
Immunohistochemistry	16
RNA in situ	70
Northern blot	6
Western blot	8
RT-PCR	14
RNase protection	7

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(11) Primer pair(1) Other(4)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000005104 (Evidence)
Ensembl Gene Model	ENSMUSG00000020469 (Evidence)
Entrez Gene	17898 (Evidence)
DFCI	TC1579480
DoTS	DT.493265, DT.94356460
NIA Mouse Gene Index	U032477
Consensus CDS Project	CCDS24408.1
International Mouse Knockout Project Status	Myl7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005104	VEGA Gene Model | MGI Sequence Detail	2146	C57BL/6J
transcript	OTTMUST00000011416	VEGA | MGI Sequence Detail	590	Not Applicable
polypeptide	OTTMUSP00000005318	VEGA | MGI Sequence Detail	175	Not Applicable

All sequences(24) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(6 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002048	Calcium-binding EF-hand
InterPro	IPR018247	EF-Hand 1, calcium-binding site
InterPro	IPR018249	EF-HAND 2
InterPro	IPR011992	EF-hand-like domain
Protein Ontology	PR:000010840	myosin regulatory light chain 2, atrial isoform

References

(Earliest) J:35864 Lowey S, et al., Light chains from fast and slow muscle myosins. Nature. 1971 Nov 12;234(5324):81-5
(Latest) J:190992 Harmelink C, et al., Myocardial Mycn is essential for mouse ventricular wall morphogenesis. Dev Biol. 2013 Jan 1;373(1):53-63
All references(142)

Other accession IDs

MGD-MRK-36063