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Myl7 Gene Detail
Summary
  • Symbol
    Myl7
  • Name
    myosin, light polypeptide 7, regulatory
  • Synonyms
    MLC2a, MLC-2alpha, Mylc2a, RLC-A
  • Feature Type
    protein coding gene
  • IDs
    MGI:107495
    NCBI Gene: 17898
  • Gene Overview
    MyGene.info: MYL7
  • Alliance
    gene page
Location & Maps
more
  • Genetic Map
    Chromosome 11, 3.88 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MYL7, myosin light chain 7
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MYL7, myosin light chain 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MYL2A, MYLC2A
  • Links
    NCBI Gene ID: 58498
    neXtProt AC: NX_Q01449
    UniProt: Q01449

  • Chr Location
    7p13; chr7:44138864-44141392 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-in allele show lack of atrial myofibrillar organization, atrial malfunction, aberrant cardiac chamber and looping morphogenesis, defects in yolk sac and intraembryonic vasculature, growth arrest, pericardial edema, and death at E10.5-E11.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    244
  • Tissues
    77
  • cDNA Data
    10
  • Literature Summary
    128
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005104 VEGA Gene Model | MGI Sequence Detail 2146 C57BL/6J ±  kb
    transcript OTTMUST00000011416 VEGA | MGI Sequence Detail 590 Not Applicable  
    polypeptide OTTMUSP00000005318 VEGA | MGI Sequence Detail 175 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      14 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 11
      Primer pair 1
      Other 10

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36063
    References
    more
    • Summaries
      All 165
      Developmental Gene Expression 128
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:35864 Lowey S, et al., Light chains from fast and slow muscle myosins. Nature. 1971 Nov 12;234(5324):81-5
    • Latest
      J:247274 Rose BA, et al., Cardiac myocyte p38alpha kinase regulates angiogenesis via myocyte-endothelial cell cross-talk during stress-induced remodeling in the heart. J Biol Chem. 2017 Aug 04;292(31):12787-12800
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/15/2018
    MGI 6.12     		The Jackson Laboratory