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Myl12b Gene Detail
Summary
  • Symbol
    Myl12b
  • Name
    myosin, light chain 12B, regulatory
  • Synonyms
    1500001M02Rik, Mylc2b, RLC-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:107494
    NCBI Gene: 67938
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:70973963-70990516 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 41.87 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107494
protein coding gene Chr17:70973920-70990787 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024002
protein coding gene Chr17:73398243-73415942 (-)
A/J MGP_AJ_G0023960
protein coding gene Chr17:71155241-71171864 (-)
AKR/J MGP_AKRJ_G0023929
protein coding gene Chr17:72136134-72154363 (-)
BALB/cJ MGP_BALBcJ_G0023961
protein coding gene Chr17:71082080-71098674 (-)
C3H/HeJ MGP_C3HHeJ_G0023725
protein coding gene Chr17:73098167-73114762 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024407
protein coding gene Chr17:76057242-76077338 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021852
protein coding gene Chr17:66937106-66953924 (-)
CAST/EiJ MGP_CASTEiJ_G0023206
protein coding gene Chr17:73511791-73529533 (-)
CBA/J MGP_CBAJ_G0023700
protein coding gene Chr17:79249120-79265880 (-)
DBA/2J MGP_DBA2J_G0023829
protein coding gene Chr17:69848465-69865142 (-)
FVB/NJ MGP_FVBNJ_G0023795
protein coding gene Chr17:69314326-69330937 (-)
LP/J MGP_LPJ_G0023911
protein coding gene Chr17:74153888-74172090 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023823
protein coding gene Chr17:79128318-79145320 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024451
protein coding gene Chr17:72655656-72672270 (-)
PWK/PhJ MGP_PWKPhJ_G0022952
protein coding gene Chr17:69144389-69161572 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022763
protein coding gene Chr17:69363762-69382394 (-)
WSB/EiJ MGP_WSBEiJ_G0023273
protein coding gene Chr17:73463713-73481745 (-)



Homology
more
  • Human Ortholog
    MYL12A, myosin light chain 12A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MYL12A, myosin light chain 12A
    Orthology source: HomoloGene
  • Synonyms
    HEL-S-24, MLC-2B, MLCB, MRCL3, MRLC3, MYL2B
  • Links
    NCBI Gene ID: 10627
    neXtProt AC: NX_O14950, NX_P19105
    UniProt: P19105

  • Chr Location
    18p11.31; chr18:3247482-3256237 (+)  GRCh38.p7

  • Human Ortholog
    MYL12B, myosin light chain 12B
    Orthology source: HGNC
  • Synonyms
    MLC-B, MRLC2
  • Links
    NCBI Gene ID: 103910
    neXtProt AC: NX_O14950
    UniProt: O14950

  • Chr Location
    18p11.31; chr18:3262113-3278284 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 67938 NCBI Gene Model | MGI Sequence Detail 16554 C57BL/6J ±  kb
transcript NM_023402 RefSeq | MGI Sequence Detail 939 C57BL/6  
polypeptide Q3THE2 UniProt | EBI | MGI Sequence Detail 172 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-36062, MGI:1915188, MGI:2147119
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:18786 Kubalak SW, et al., Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis. J Biol Chem. 1994 Jun 17;269(24):16961-70
  • Latest
    J:244106 Lin C, et al., YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis. Elife. 2017 Mar 21;6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory