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Pdcd4 Gene Detail
Summary
  • Symbol
    Pdcd4
  • Name
    programmed cell death 4
  • Synonyms
    D19Ucla1, MA-3, TIS
  • Feature Type
    protein coding gene
  • IDs
    MGI:107490
    NCBI Gene: 18569
  • Gene Overview
    MyGene.info: PDCD4
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:53892231-53929861 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 48.73 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    195 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107490
protein coding gene Chr19:53892231-53929861 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025250
protein coding gene Chr19:54069966-54107954 (+)
A/J MGP_AJ_G0025226
protein coding gene Chr19:51408017-51447122 (+)
AKR/J MGP_AKRJ_G0025195
protein coding gene Chr19:53031194-53071264 (+)
BALB/cJ MGP_BALBcJ_G0025221
protein coding gene Chr19:51495129-51533439 (+)
C3H/HeJ MGP_C3HHeJ_G0024981
protein coding gene Chr19:53248544-53287979 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025664
protein coding gene Chr19:55372097-55411065 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023076
protein coding gene Chr19:50396176-50435163 (+)
CAST/EiJ MGP_CASTEiJ_G0024446
protein coding gene Chr19:53215208-53254131 (+)
CBA/J MGP_CBAJ_G0024961
protein coding gene Chr19:58129718-58180698 (+)
DBA/2J MGP_DBA2J_G0025093
protein coding gene Chr19:51218590-51256686 (+)
FVB/NJ MGP_FVBNJ_G0025054
protein coding gene Chr19:50935890-50975122 (+)
LP/J MGP_LPJ_G0025179
protein coding gene Chr19:53959205-53997553 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025087
protein coding gene Chr19:57557736-57599388 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025722
protein coding gene Chr19:53226560-53264344 (+)
PWK/PhJ MGP_PWKPhJ_G0024194
protein coding gene Chr19:51126923-51166208 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023997
protein coding gene Chr19:51891941-51938787 (+)
WSB/EiJ MGP_WSBEiJ_G0024516
protein coding gene Chr19:53353651-53393588 (+)



Homology
more
  • Human Ortholog
    PDCD4, programmed cell death 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDCD4, programmed cell death 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    H731
  • Links
    NCBI Gene ID: 27250
    neXtProt AC: NX_Q53EL6
    UniProt: Q53EL6

  • Chr Location
    10q25.2; chr10:110871795-110900006 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7879
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PDCD4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele have a higher prevalence of B cell derived lymphomas, multi-organ cysts and decreased susceptibility to experimentally induced autoimmune encephalomyelitis and type 1 diabetes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18569 NCBI Gene Model | MGI Sequence Detail 37631 C57BL/6J ±  kb
    transcript NM_011050 RefSeq | MGI Sequence Detail 2418 C57BL/6  
    polypeptide Q61823 UniProt | EBI | MGI Sequence Detail 469 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      Genomic 2
      cDNA 61
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36058, MGD-MRK-5191, MGI:91341
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
    • Latest
      J:261296 Lingel H, et al., CTLA-4-mediated posttranslational modifications direct cytotoxic T-lymphocyte differentiation. Cell Death Differ. 2017 Oct;24(10):1739-1749

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory