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Pdcd4
Gene Detail
Symbol

Name
ID
Pdcd4
programmed cell death 4
MGI:107490
Synonyms
D19Ucla1, MA-3, TIS
Feature Type
protein coding gene
Genetic Map
Chromosome 19
48.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr19:53892231-53929861 bp, + strand
From NCBI annotation of GRCm38

  37631 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7879  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pdcd4

Human
homologs
Human Homolog PDCD4, programmed cell death 4 (neoplastic transformation inhibitor)
NCBI Gene ID 27250
neXtProt AC  NX_Q53EL6
Human Synonyms  H731
Human Chr (Location)  10q24; chr10:110871795-110900006 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele have a higher prevalence of B cell derived lymphomas, multi-organ cysts and decreased susceptibility to experimentally induced autoimmune encephalomyelitis and type 1 diabetes.
 
Interactions
Pdcd4 interacts with 175 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process apoptotic process, cell aging, ...
Component cytoplasm, cytosol, ...
Function protein binding, RNA binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (136)    Tissues (27)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 82
Northern blot 18
RT-PCR 36
cDNA source data(58)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(65) Genomic(2) cDNA(60) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000024975 (Evidence)
Entrez Gene18569 (Evidence)
UniGene1605
DFCITC1777626, TC1578905
PDB2ION, 2IOL, 2KZT, 2IOS, 2NSZ, 3EIQ, 2HM8
Consensus CDS ProjectCCDS29903.1
International Mouse Knockout Project StatusPdcd4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18569 NCBI Gene Model | MGI Sequence Detail 37631 C57BL/6J ±  kb
transcript NM_011050 RefSeq | MGI Sequence Detail 2418 C57BL/6 
polypeptide Q61823 UniProt | EBI | MGI Sequence Detail 469 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(8) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(196 from dbSNP Build 137)    SNPs within 2kb including multiple locations(198)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR003891 Initiation factor eIF-4 gamma, MA3
InterPro IPR016021 MIF4-like, type 1/2/3
Protein Ontology PR:000012455 programmed cell death protein 4
Graphical View of Protein Domain Structure
References
(Earliest) J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
(Latest) J:208925 Wang Q, et al., Programmed cell death-4 deficiency prevents diet-induced obesity, adipose tissue inflammation, and insulin resistance. Diabetes. 2013 Dec;62(12):4132-43
All references(48)
Other
accession IDs
MGD-MRK-36058, MGD-MRK-5191, MGI:91341

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory