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Pdcd4 Gene Detail
Summary
  • Symbol
    Pdcd4
  • Name
    programmed cell death 4
  • Synonyms
    D19Ucla1, MA-3, TIS
  • Feature Type
    protein coding gene
  • IDs
    MGI:107490
    NCBI Gene: 18569
  • Gene Overview
    MyGene.info: PDCD4
Location & Maps
more
  • Sequence Map
    Chr19:53892231-53929861 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37631 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 48.73 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    PDCD4, programmed cell death 4 (neoplastic transformation inhibitor)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDCD4, programmed cell death 4 (neoplastic transformation inhibitor)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    H731
  • Links
    NCBI Gene ID: 27250
    neXtProt AC: NX_Q53EL6

  • Chr Location
    10q24; chr10:110871795-110900006 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7879
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PDCD4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    1
  • Targeted
    4
  • Transgenic
    1
  • Incidental Mutations
Mice homozygous for a null allele have a higher prevalence of B cell derived lymphomas, multi-organ cysts and decreased susceptibility to experimentally induced autoimmune encephalomyelitis and type 1 diabetes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18569 NCBI Gene Model | MGI Sequence Detail 37631 C57BL/6J ±  kb
transcript NM_011050 RefSeq | MGI Sequence Detail 2418 C57BL/6  
polypeptide Q61823 UniProt | EBI | MGI Sequence Detail 469 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    195 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 65
    Genomic 2
    cDNA 60
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-36058, MGD-MRK-5191, MGI:91341
References
more
  • Summaries
    All 46
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
  • Latest
    J:225926 Junker F, et al., Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21-mediated tumor suppressor Pdcd4 repression. Blood. 2015 Aug 20;126(8):993-1004

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory