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Pxmp2
Gene Detail
Symbol

Name
ID
Pxmp2
peroxisomal membrane protein 2
MGI:107487
Synonyms
22kDa, PMP22
Feature Type
protein coding gene
Genetic Map
Chromosome 5
53.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:110274282-110286186 bp, - strand
From VEGA annotation of GRCm38

  11905 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32062  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PXMP2
Protein SuperFamily: mitocondrial membrane protein, Mpv17/PMP22
Gene Tree: Pxmp2

Human
homologs
PXMP2, peroxisomal membrane protein 2, 22kDa
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5827
neXtProt AC: NX_Q9NR77

Human Synonyms: PMP22

Human Chr (Location): 12q24.33; chr12:132687606-132704991 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from CvDC )
 
Mice homozygous for a null mutation display impaired lactation, increased serum urate levels, elevated urinary clearence of urate, and abnormal liver peroxisomal membrane permeability.
 
Interactions
Pxmp2 interacts with 66 markers (Mir20a, Mir22, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Component cytoplasm, integral component of membrane, ...
External Resources: FuncBase
Expression
cDNA source data(32)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pxmp2 ; ZFIN pxmp2    NEW 
Molecular
reagents
All nucleic(33) cDNA(32) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000026216 (Evidence)
Ensembl Gene Model ENSMUSG00000029499 (Evidence)
Entrez Gene 19301 (Evidence)
UniGene 21853
DFCI TC1669533, TC1580973
DoTS DT.532949
NIA Mouse Gene Index U026555
Consensus CDS Project CCDS19524.1
International Mouse Phenotyping Consortium Status Pxmp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026216 VEGA Gene Model | MGI Sequence Detail 11905 C57BL/6J ±  kb
transcript OTTMUST00000064832 VEGA | MGI Sequence Detail 1041 Not Applicable 
polypeptide OTTMUSP00000032236 VEGA | MGI Sequence Detail 193 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(128 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007248 Mpv17/PMP22
Protein Ontology PR:000013509 peroxisomal membrane protein 2
References
(Earliest) J:27776 Bryant DD, et al., Differential evolution and expression of murine peroxisomal membrane protein genes. Biochem Mol Med. 1995 Jun;55(1):22-30
(Latest) J:213750 Vapola MH, et al., Peroxisomal membrane channel Pxmp2 in the mammary fat pad is essential for stromal lipid homeostasis and for development of mammary gland epithelium in mice. Dev Biol. 2014 Jul 1;391(1):66-80
All references(34)
Other
accession IDs
MGD-MRK-36055

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory