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Ralgds Gene Detail
Summary
  • Symbol
    Ralgds
  • Name
    ral guanine nucleotide dissociation stimulator
  • Synonyms
    Gnds, mKIAA1308, RalGDS, Rgds
  • Feature Type
    protein coding gene
  • IDs
    MGI:107485
    NCBI Gene: 19730
  • Gene Overview
    MyGene.info: RALGDS
Location & Maps
more
  • Sequence Map
    Chr2:28513125-28553081 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      39957 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 19.38 cM, cytoband A3
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RALGDS, ral guanine nucleotide dissociation stimulator
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RALGDS, ral guanine nucleotide dissociation stimulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RalGEF, RGDS, RGF
  • Links
    NCBI Gene ID: 5900
    neXtProt AC: NX_Q12967

  • Chr Location
    9q34.3; chr9:133097720-133149220 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4562
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: RALGDS
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Gene trapped
    11
  • Targeted
    5
  • Incidental Mutations
Homozygous mutant mice exhibit reduced tumor incidence, size and progression to malignancy in multistage skin carcinogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011643 VEGA Gene Model | MGI Sequence Detail 39957 C57BL/6J ±  kb
transcript OTTMUST00000027250 VEGA | MGI Sequence Detail 3102 Not Applicable  
polypeptide OTTMUSP00000012394 VEGA | MGI Sequence Detail 907 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    101 from dbSNP Build 142
Protein
Information
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  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000013698 ral guanine nucleotide dissociation stimulator
  • InterPro Domains
    IPR015758 Ral guanine nucleotide dissociation stimulator
    IPR000159 Ras-associating (RA) domain
    IPR019804 Ras guanine-nucleotide exchange factor, conserved site
    IPR023578 Ras guanine nucleotide exchange factor domain
    IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
    IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
    IPR029071 Ubiquitin-related domain
Molecular
Reagents
less
  • All nucleic 175
    cDNA 175

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36053
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:25192 Albright CF, et al., Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase. EMBO J. 1993 Jan;12(1):339-47
  • Latest
    J:233777 Ray JP, et al., The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20;43(4):690-702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory