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Rgl1 Gene Detail
Summary
  • Symbol
    Rgl1
  • Name
    ral guanine nucleotide dissociation stimulator,-like 1
  • Synonyms
    Rgl
  • Feature Type
    protein coding gene
  • IDs
    MGI:107484
    NCBI Gene: 19731
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:152392513-152642056 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 64.85 cM, cytoband G2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7002 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107484
 protein coding gene Chr1:152392511-152642102 (-)
129S1/SvImJ ENSMUSG00200002098
 protein coding gene Chr1:149835696-150081740 (-)
A/J ENSMUSG00195013201
 protein coding gene Chr1:149210625-149460261 (-)
AKR/J ENSMUSG00220004964
 protein coding gene Chr1:149006140-149258657 (-)
BALB/cJ ENSMUSG00180031679
 protein coding gene Chr1:149440321-149689967 (-)
C3H/HeJ ENSMUSG00175002812
 protein coding gene Chr1:149477244-149726848 (-)
C57BL/6NJ ENSMUSG00215003250
 protein coding gene Chr1:149375308-149624934 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014700
 protein coding gene Chr1:143263424-143511293 (-)
CAST/EiJ ENSTCUG00005005551
 protein coding gene Chr1:148008183-148260438 (-)
CBA/J ENSMUSG00210033538
 protein coding gene Chr1:149381110-149630706 (-)
DBA/2J ENSMUSG00185042602
 protein coding gene Chr1:153632974-153887794 (-)
FVB/NJ ENSMUSG00205025285
 protein coding gene Chr1:148503215-148752917 (-)
JF1/MsJ ENSUMUG00000012478
 protein coding gene Chr1:152810049-153062246 (-)
LP/J ENSMUSG00230012806
 protein coding gene Chr1:153204033-153455696 (-)
NOD/ShiLtJ ENSMUSG00190012009
 protein coding gene Chr1:149189436-149444234 (-)
NZO/HlLtJ ENSMUSG00225005642
 protein coding gene Chr1:156880110-157133465 (-)
PWK/PhJ ENSLUMG00010026616
 protein coding gene Chr1:148158058-148411615 (-)
SPRET/EiJ ENSMSPG00010005146
 protein coding gene Chr1:151497411-151739513 (-)
WSB/EiJ ENSIUOG00005021239
 protein coding gene Chr1:148785907-149031276 (-)



Homology
more
  • Human Ortholog
    RGL1, ral guanine nucleotide dissociation stimulator like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RGL1, ral guanine nucleotide dissociation stimulator like 1
  • Synonyms
    RGL
  • Links
    NCBI Gene ID: 23179
    UniProt: Q9NZL6

  • Chr Location
    1q25.3; chr1:183636085-183928532 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    58
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19731 NCBI Gene Model | MGI Sequence Detail 249544 C57BL/6J ±  kb
    transcript NM_001346117 RefSeq | MGI Sequence Detail 5093 C57BL/6  
    polypeptide Q60695 UniProt | EBI | MGI Sequence Detail 768 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000013936 Ral guanine nucleotide dissociation stimulator-like 1
      (term hierarchy)
    • PDB
      1EF5
    • InterPro Domains
      IPR030748 Ral guanine nucleotide dissociation stimulator-like 1, RA domain
      IPR000159 Ras-associating domain
      IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily
      IPR019804 Ras guanine-nucleotide exchange factor, conserved site
      IPR023578 Ras guanine nucleotide exchange factor domain superfamily
      IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
      IPR008937 Ras-like guanine nucleotide exchange factor
      IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
      IPR029071 Ubiquitin-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 58

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36052
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:47441 Kikuchi A, et al., ralGDS family members interact with the effector loop of ras p21. Mol Cell Biol. 1994 Nov;14(11):7483-91
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory