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Rgl1 Gene Detail
Summary
  • Symbol
    Rgl1
  • Name
    ral guanine nucleotide dissociation stimulator,-like 1
  • Synonyms
    Rgl
  • Feature Type
    protein coding gene
  • IDs
    MGI:107484
    NCBI Gene: 19731
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:152516762-152766270 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 64.85 cM, cytoband G2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2614 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107484
protein coding gene Chr1:152516760-152766351 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016588
protein coding gene Chr1:157277882-157536083 (-)
A/J MGP_AJ_G0016570
protein coding gene Chr1:150944702-151192818 (-)
AKR/J MGP_AKRJ_G0016535
protein coding gene Chr1:155594245-155854361 (-)
BALB/cJ MGP_BALBcJ_G0016530
protein coding gene Chr1:151517707-151765641 (-)
C3H/HeJ MGP_C3HHeJ_G0016355
protein coding gene Chr1:155715839-155971457 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016991
protein coding gene Chr1:162723948-162989688 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014700
protein coding gene Chr1:143263424-143511293 (-)
CAST/EiJ MGP_CASTEiJ_G0015934
protein coding gene Chr1:155204574-155474647 (-)
CBA/J MGP_CBAJ_G0016329
protein coding gene Chr1:168438513-168720746 (-)
DBA/2J MGP_DBA2J_G0016435
protein coding gene Chr1:149965019-150208015 (-)
FVB/NJ MGP_FVBNJ_G0016433
protein coding gene Chr1:148439957-148694568 (-)
LP/J MGP_LPJ_G0016506
protein coding gene Chr1:158389502-158649042 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016459
protein coding gene Chr1:176099766-176370496 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017027
protein coding gene Chr1:155372792-155641409 (-)
PWK/PhJ MGP_PWKPhJ_G0015720
protein coding gene Chr1:148957225-149217017 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015507
protein coding gene Chr1:154200617-154448934 (-)
WSB/EiJ MGP_WSBEiJ_G0015997
protein coding gene Chr1:155451875-155705495 (-)



Homology
more
  • Human Ortholog
    RGL1, ral guanine nucleotide dissociation stimulator like 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RGL1, ral guanine nucleotide dissociation stimulator like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RGL
  • Links
    NCBI Gene ID: 23179
    neXtProt AC: NX_Q9NZL6
    UniProt: Q9NZL6

  • Chr Location
    1q25.3; chr1:183636047-183928551 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 19731 NCBI Gene Model | MGI Sequence Detail 249509 C57BL/6J ±  kb
transcript NM_001346117 RefSeq | MGI Sequence Detail 5093 C57BL/6  
polypeptide Q60695 UniProt | EBI | MGI Sequence Detail 768 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • PDB
  • InterPro Domains
    IPR030748 Ral guanine nucleotide dissociation stimulator-like 1
    IPR000159 Ras-associating (RA) domain
    IPR036964 Ras guanine-nucleotide exchange factor catalytic domain superfamily
    IPR019804 Ras guanine-nucleotide exchange factor, conserved site
    IPR023578 Ras guanine nucleotide exchange factor domain superfamily
    IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
    IPR008937 Ras-like guanine nucleotide exchange factor
    IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
    IPR029071 Ubiquitin-like domain superfamily
Molecular
Reagents
less
  • All nucleic 58
    cDNA 58

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-36052
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:47441 Kikuchi A, et al., ralGDS family members interact with the effector loop of ras p21. Mol Cell Biol. 1994 Nov;14(11):7483-91
  • Latest
    J:218136 Kirkby NS, et al., COX-2 protects against atherosclerosis independently of local vascular prostacyclin: identification of COX-2 associated pathways implicate Rgl1 and lymphocyte networks. PLoS One. 2014;9(6):e98165

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory