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Stim1
Gene Detail
 Symbol
Name
ID
Stim1
stromal interaction molecule 1
MGI:107476
Synonyms SIM
Feature Type protein coding gene
Genetic Map
Chromosome 7
54.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:102267824-102436848 bp, + strand
From Ensembl annotation of GRCm38

  169025 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20681  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Stim1

Human
homologs
Human Homolog STIM1, stromal interaction molecule 1
NCBI Gene ID 6786
neXtProt AC  NX_Q13586
Human Synonyms  D11S4896E, GOK, IMD10, STRMK, TAM, TAM1
Human Chr (Location)  11p15.5; chr11:3855703-4093210 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human STIM1
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Chemically induced (ENU)(1) Gene trapped(7) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit perinatal and postnatal lethality, with all mice dieing by 2 weeks of age, and severe growth retardation.
 
Phenotype Images(2)
Interactions
Stim1 interacts with 201 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process activation of store-operated calcium channel activity, calcium ion transmembrane transport, ...
Component cortical endoplasmic reticulum, cytoplasm, ...
Function calcium channel regulator activity, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (153)    Tissues (22)    Images (24)
Theiler Stages: 21, 23
Assay TypeResults
RNA in situ 145
RT-PCR 8
cDNA source data(80)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(87) Genomic(1) cDNA(82) Primer pair(2) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000030987 (Evidence)
Entrez Gene20866 (Evidence)
UniGene645
DFCITC1576970, TC1640932, TC1721163, TC1728385, TC1742707
DoTSDT.111009388, DT.111009389, DT.490350, DT.94351061, DT.94351103
NIA Mouse Gene IndexU042849
Consensus CDS ProjectCCDS21530.1
International Mouse Knockout Project StatusStim1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030987 Ensembl Gene Model | MGI Sequence Detail 169025 C57BL/6J ±  kb
transcript ENSMUST00000033289 Ensembl | MGI Sequence Detail 3597 Not Applicable 
polypeptide ENSMUSP00000033289 Ensembl | MGI Sequence Detail 685 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(12) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(2149 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011510 Sterile alpha motif, type 2
Protein Ontology PR:000015736 stromal interaction molecule 1
References (Earliest) J:34568 Oritani K, et al., Identification of stromal cell products that interact with pre-B cells. J Cell Biol. 1996 Aug;134(3):771-82
(Latest) J:210742 Collins HE, et al., Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function. Am J Physiol Heart Circ Physiol. 2014 Apr 15;306(8):H1231-9
All references(71)
Other
accession IDs
MGD-MRK-36043, MGD-MRK-37442, MGI:108400

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory