Stim1
Gene Detail

Symbol Name ID

Stim1 stromal interaction molecule 1 MGI:107476

Synonyms

SIM

Feature Type

protein coding gene

Genetic Map

Chromosome 7

54.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:102267824-102436848 bp, + strand From Ensembl annotation of GRCm38   169025 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20681  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Stim1

Human homologs

Human Homolog		STIM1, stromal interaction molecule 1
NCBI Gene ID		6786
neXtProt AC		NX_Q13586
Human Synonyms		D11S4896E, GOK, TAM
Human Chr (Location)		11p15.5; chr11:3876933-4114440 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human STIM1

Alleles and phenotypes

All alleles(14) : Targeted(6) Gene trapped(7) Chemically induced(1)
 

Mice homozygous for a null allele exhibit perinatal and postnatal lethality, with all mice dieing by 2 weeks of age, and severe growth retardation.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	activation of store-operated calcium channel activity, calcium ion transport, ...
Component	cortical endoplasmic reticulum, cytoplasm, ...
Function	calcium channel regulator activity, calcium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (153)    Tissues (22)    Images (24)
Theiler Stages: 21, 23

Assay Type	Results
RNA in situ	145
RT-PCR	8

cDNA source data(81)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(88) Genomic(1) cDNA(83) Primer pair(2) Other(2)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000030987 (Evidence)
Entrez Gene	20866 (Evidence)
UniGene	645
DFCI	TC1576970, TC1640932, TC1721163, TC1728385, TC1742707
DoTS	DT.111009388, DT.111009389, DT.490350, DT.94351061, DT.94351103
NIA Mouse Gene Index	U042849
Consensus CDS Project	CCDS21530.1
International Mouse Knockout Project Status	Stim1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000030987	Ensembl Gene Model | MGI Sequence Detail	169025	C57BL/6J
transcript	ENSMUST00000033289	Ensembl | MGI Sequence Detail	3597	Not Applicable
polypeptide	ENSMUSP00000033289	Ensembl | MGI Sequence Detail	685	Not Applicable

All sequences(33) RefSeq(2) UniProt(2)

Polymorphisms

PCR(1) : SNPs(651 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001660	Sterile alpha motif domain
InterPro	IPR013761	Sterile alpha motif/pointed domain
InterPro	IPR011510	Sterile alpha motif, type 2
Protein Ontology	PR:000015736	stromal interaction molecule 1

References

(Earliest) J:34568 Oritani K, et al., Identification of stromal cell products that interact with pre-B cells. J Cell Biol. 1996 Aug;134(3):771-82
(Latest) J:194484 Gandhirajan RK, et al., Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation. J Clin Invest. 2013 Jan 25;
All references(59)

Other accession IDs

MGD-MRK-36043, MGD-MRK-37442, MGI:108400