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Stim1
Gene Detail
Symbol

Name
ID
Stim1
stromal interaction molecule 1
MGI:107476
Synonyms
SIM
Feature Type
protein coding gene
Genetic Map
Chromosome 7
54.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:102267824-102436848 bp, + strand
From Ensembl annotation of GRCm38

  169025 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20681  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: STIM1
Gene Tree: Stim1

Human
homologs
STIM1, stromal interaction molecule 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6786
neXtProt AC: NX_Q13586

Human Synonyms: D11S4896E, GOK, IMD10, STRMK, TAM, TAM1

Human Chr (Location): 11p15.5; chr11:3855703-4093210 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human STIM1

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Chemically induced (ENU)(1) Gene trapped(7) Targeted(6) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit perinatal and postnatal lethality, with all mice dying by 2 weeks of age, and severe growth retardation.
 
Phenotype Images(2)
Interactions
Stim1 interacts with 201 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (153)    Tissues (22)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 145
RT-PCR 8
cDNA source data(80)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase stim1    NEW 
Molecular
reagents
All nucleic(87) Genomic(1) cDNA(82) Primer pair(2) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000030987 (Evidence)
Entrez Gene 20866 (Evidence)
UniGene 645
DFCI TC1576970, TC1640932, TC1721163, TC1728385, TC1742707
DoTS DT.111009388, DT.111009389, DT.490350, DT.94351061, DT.94351103
NIA Mouse Gene Index U042849
Consensus CDS Project CCDS21530.1
International Mouse Phenotyping Consortium Status Stim1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030987 Ensembl Gene Model | MGI Sequence Detail 169025 C57BL/6J ±  kb
transcript ENSMUST00000033289 Ensembl | MGI Sequence Detail 3597 Not Applicable 
polypeptide ENSMUSP00000033289 Ensembl | MGI Sequence Detail 685 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(12) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(2149 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR030463 Stromal interaction molecule 1
Protein Ontology PR:000015736 stromal interaction molecule 1
References
(Earliest) J:34568 Oritani K, et al., Identification of stromal cell products that interact with pre-B cells. J Cell Biol. 1996 Aug;134(3):771-82
(Latest) J:222964 Desvignes L, et al., STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection. J Clin Invest. 2015 Jun;125(6):2347-62
All references(76)
Other
accession IDs
MGD-MRK-36043, MGD-MRK-37442, MGI:108400

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory