Csn3 MGI Mouse Gene Detail - MGI:107461

Symbol

Csn3
Name

casein kappa
Synonyms

CSN10, Csnk

Feature Type

protein coding gene
IDs

MGI:107461
NCBI Gene: 12994
Member of

Csn cluster
Alliance

gene page
Transcription Start Sites

20 TSS

Sequence Map

Chr5:88073438-88080409 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 43.56 cM
Mapping Data

9 experiments

SNPs within 2kb

46 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107461	protein coding gene	Chr5:88073438-88080524 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029695	protein coding gene	Chr5:88899086-88907161 (+)
A/J	MGP_AJ_G0029662	protein coding gene	Chr5:85270019-85277490 (+)
AKR/J	MGP_AKRJ_G0029608	protein coding gene	Chr5:88090829-88097780 (+)
BALB/cJ	MGP_BALBcJ_G0029671	protein coding gene	Chr5:86188915-86195790 (+)
C3H/HeJ	MGP_C3HHeJ_G0029394	protein coding gene	Chr5:88493822-88500851 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030126	protein coding gene	Chr5:92548760-92555371 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027364	protein coding gene	Chr5:80871624-80878652 (+)
CAST/EiJ	MGP_CASTEiJ_G0028804	protein coding gene	Chr5:87889860-87897318 (+)
CBA/J	MGP_CBAJ_G0029363	protein coding gene	Chr5:95470066-95480181 (+)
DBA/2J	MGP_DBA2J_G0029508	protein coding gene	Chr5:85441086-85447982 (+)
FVB/NJ	MGP_FVBNJ_G0029468	protein coding gene	Chr5:84348200-84355470 (+)
LP/J	MGP_LPJ_G0029596	protein coding gene	Chr5:89309420-89317326 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029497	protein coding gene	Chr5:100574245-100590899 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030159	protein coding gene	Chr5:87662352-87669346 (+)
PWK/PhJ	MGP_PWKPhJ_G0028523	protein coding gene	Chr5:84432775-84440227 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028361	protein coding gene	Chr5:87076455-87083433 (+)
WSB/EiJ	MGP_WSBEiJ_G0028883	protein coding gene	Chr5:88049608-88059341 (+)

Human Ortholog

CSN3, casein kappa

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CSN3, casein kappa
Synonyms

CNS10, CSN10, CSNK, KCA
Links

HGNC:2446

NCBI Gene ID: 1448

neXtProt AC: NX_P07498

UniProt: P07498
Chr Location

4q13.3; chr4:70238381-70251474 (+) GRCh38

MGI Vertebrate Homology

Csn3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CSN3
Protein SuperFamily

Casein_kappa
Gene Tree

Csn3

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

2
Gene trapped

2
Radiation induced

1
Spontaneous

1
Targeted

2
Genomic Mutations

4 involving Csn3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display lactation failure and abnormal milk composition, but are fertile.

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All GO Annotations

7
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

747
Tissues

27
cDNA Data

761
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

48
RefSeq

6
UniProt

2
CCDS

CCDS19396.1

Ensembl

ENSMUSG00000001622 (Evidence)
NCBI Gene

12994

			Length	Strain/Species	Flank
genomic	12994	NCBI Gene Model \| MGI Sequence Detail	6972	C57BL/6J	± kb
transcript	NM_007786	RefSeq \| MGI Sequence Detail	1651	ZRU/MplStud
polypeptide	P06796	UniProt \| EBI \| MGI Sequence Detail	181	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005942 kappa-casein

(term hierarchy)
InterPro Domains

IPR000117 Kappa casein

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All nucleic 770

Genomic 6

cDNA 763

Other 1

Microarray probesets 4

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MGD-MRK-35932, MGI:2141168

Summaries

All 44

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 13
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:200642 Komori R, et al., Csn3 gene is regulated by all-trans retinoic acid during neural differentiation in mouse P19 cells. PLoS One. 2013;8(4):e61938

TSS for Csn3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46938	Chr5:88073453-88073480 (+)	29 bp
Tssr46939	Chr5:88073483-88073498 (+)	53 bp
Tssr46940	Chr5:88074890-88074908 (+)	1,461 bp
Tssr46941	Chr5:88075429-88075450 (+)	2,002 bp
Tssr46942	Chr5:88076120-88076133 (+)	2,689 bp
Tssr46943	Chr5:88077587-88077598 (+)	4,155 bp
Tssr46944	Chr5:88077615-88077633 (+)	4,186 bp
Tssr46945	Chr5:88077637-88077654 (+)	4,208 bp
Tssr46946	Chr5:88077659-88077662 (+)	4,223 bp
Tssr46947	Chr5:88077669-88077674 (+)	4,234 bp
Tssr46948	Chr5:88077688-88077708 (+)	4,260 bp
Tssr46949	Chr5:88077712-88077724 (+)	4,280 bp
Tssr46950	Chr5:88077727-88077731 (+)	4,291 bp
Tssr46951	Chr5:88077733-88077737 (+)	4,297 bp
Tssr46952	Chr5:88077744-88077765 (+)	4,317 bp
Tssr46953	Chr5:88077768-88077775 (+)	4,334 bp
Tssr46954	Chr5:88077781-88077807 (+)	4,356 bp
Tssr46955	Chr5:88077817-88077820 (+)	4,381 bp
Tssr46956	Chr5:88080252-88080257 (+)	6,817 bp
Tssr46957	Chr5:88080304-88080313 (+)	6,871 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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