About   Help   FAQ
Mzf1 Gene Detail
Summary
  • Symbol
    Mzf1
  • Name
    myeloid zinc finger 1
  • Synonyms
    Mzf2, Zfp121, Zfp98, Znf42
  • Feature Type
    protein coding gene
  • IDs
    MGI:107457
    NCBI Gene: 109889
  • Gene Overview
    MyGene.info: MZF1
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr7:13042303-13054764 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 7.73 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    27 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107457
protein coding gene Chr7:13042303-13054764 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031665
protein coding gene Chr7:10451750-10463187 (-)
A/J MGP_AJ_G0031638
protein coding gene Chr7:10291469-10303508 (-)
AKR/J MGP_AKRJ_G0031561
protein coding gene Chr7:10520539-10532036 (-)
BALB/cJ MGP_BALBcJ_G0031643
protein coding gene Chr7:10405950-10417421 (-)
C3H/HeJ MGP_C3HHeJ_G0031365
protein coding gene Chr7:10625444-10637891 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032107
protein coding gene Chr7:10980694-11000141 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029201
protein coding gene Chr7:11889406-11901985 (-)
CAST/EiJ MGP_CASTEiJ_G0030723
protein coding gene Chr7:8182429-8194172 (-)
CBA/J MGP_CBAJ_G0031322
protein coding gene Chr7:11201279-11217673 (-)
DBA/2J MGP_DBA2J_G0031480
protein coding gene Chr7:10173941-10185351 (-)
FVB/NJ MGP_FVBNJ_G0031436
protein coding gene Chr7:10171662-10183600 (-)
LP/J MGP_LPJ_G0031567
protein coding gene Chr7:10537693-10550636 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031471
protein coding gene Chr7:11288231-11301165 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032137
protein coding gene Chr7:10308190-10320467 (-)
PWK/PhJ MGP_PWKPhJ_G0030451
protein coding gene Chr7:8657899-8669586 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030277
protein coding gene Chr7:6418839-6432996 (-)
WSB/EiJ MGP_WSBEiJ_G0030818
protein coding gene Chr7:10337560-10351415 (-)



Homology
more
  • Human Ortholog
    MZF1, myeloid zinc finger 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MZF1, myeloid zinc finger 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MZF-1, MZF1B, ZFP98, ZNF42, ZSCAN6
  • Links
    NCBI Gene ID: 7593
    neXtProt AC: NX_P28698
    UniProt: P28698

  • Chr Location
    19q13.43; chr19:58561917-58573851 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants are prone to late-onset (>2 yr) neoplasias characterized by infiltration, enlargement and disruption of the liver by monomorphic cells of myeloid origin; hemopoietic progenitors show increased ability to sustain long-term hemopoiesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 109889 NCBI Gene Model | MGI Sequence Detail 12462 C57BL/6J ±  kb
    transcript NM_001290453 RefSeq | MGI Sequence Detail 3597 C57BL/6  
    polypeptide NP_665818 RefSeq | MGI Sequence Detail 735 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 1
      cDNA 14

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-35928, MGI:1858228
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 5
      Gene Ontology 1
      Phenotypes 3
    • Earliest
      J:38835 Hromas R, et al., A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells. J Biol Chem. 1991 Aug 5;266(22):14183-7
    • Latest
      J:194035 Kan A, et al., c-Jun is required for the specification of joint cell fates. Genes Dev. 2013 Mar 1;27(5):514-24

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory