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Dbx2 Gene Detail
Summary
  • Symbol
    Dbx2
  • Name
    developing brain homeobox 2
  • Synonyms
    9430056A22Rik, LOC383001
  • Feature Type
    protein coding gene
  • IDs
    MGI:107445
    NCBI Gene: 223843
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:95521444-95552838 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 50.47 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1043 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107445
 protein coding gene Chr15:95521444-95553841 (-)
129S1/SvImJ ENSMUSG00200046692
 protein coding gene Chr15:92724789-92757262 (-)
A/J ENSMUSG00195039030
 protein coding gene Chr15:92578668-92611156 (-)
AKR/J ENSMUSG00220048025
 protein coding gene Chr15:92582309-92614809 (-)
BALB/cJ ENSMUSG00180037238
 protein coding gene Chr15:92491859-92524259 (-)
C3H/HeJ ENSMUSG00175032451
 protein coding gene Chr15:92761242-92793764 (-)
C57BL/6NJ ENSMUSG00215047786
 protein coding gene Chr15:92554793-92587197 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020200
 protein coding gene Chr15:89368847-89401857 (-)
CAST/EiJ ENSTCUG00005042480
 protein coding gene Chr15:92052677-92085148 (-)
CBA/J ENSMUSG00210030543
 protein coding gene Chr15:92542434-92574900 (-)
DBA/2J ENSMUSG00185034664
 protein coding gene Chr15:92590348-92622825 (-)
FVB/NJ ENSMUSG00205025705
 protein coding gene Chr15:92302793-92335274 (-)
JF1/MsJ ENSUMUG00000046845
 protein coding gene Chr15:92069870-92102596 (-)
LP/J ENSMUSG00230033842
 protein coding gene Chr15:95904490-95936964 (-)
NOD/ShiLtJ ENSMUSG00190042131
 protein coding gene Chr15:92602907-92635387 (-)
NZO/HlLtJ ENSMUSG00225041437
 protein coding gene Chr15:96207799-96240275 (-)
PWK/PhJ ENSLUMG00010049055
 protein coding gene Chr15:92242235-92274714 (-)
SPRET/EiJ ENSMSPG00010035044
 protein coding gene Chr15:94064373-94096012 (-)
WSB/EiJ ENSIUOG00005037676
 protein coding gene Chr15:92651611-92684079 (-)



Homology
more
  • Human Ortholog
    DBX2, developing brain homeobox 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DBX2, developing brain homeobox 2
  • Links
    NCBI Gene ID: 440097
    UniProt: Q6ZNG2

  • Chr Location
    12q12; chr12:45014672-45051099 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous or heterozygous for a null allele exhibit partial preweaning lethality, but normal skeleton phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    843
  • Tissues
    177
  • cDNA Data
    8
  • Literature Summary
    37
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 223843 NCBI Gene Model | MGI Sequence Detail 31395 C57BL/6J ±  kb
    transcript NM_207533 RefSeq | MGI Sequence Detail 2271 ZRU/MplStud  
    polypeptide NP_997416 RefSeq | MGI Sequence Detail 377 ZRU/MplStud  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 8
      Primer pair 3
      Other 4
      Antibodies 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-35916, MGI:2146074, MGI:2686075
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 37
      Diseases 1
      Gene Ontology 5
      Phenotypes 29
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory