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Efna5
Gene Detail
Symbol

Name
ID
Efna5
ephrin A5
MGI:107444
Synonyms
AL-1, EFL-5, Ephrin-A5, Epl7, LERK-7, RAGS
Feature Type
protein coding gene
Genetic Map
Chromosome 17
32.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:62604184-62881317 bp, - strand
From VEGA annotation of GRCm38

  277134 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1482  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EFNA5
Protein SuperFamily: Ephrin-A
Gene Tree: Efna5

Human
homologs
EFNA5, ephrin-A5
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1946
neXtProt AC: NX_P52803

Human Synonyms: AF1, EFL5, EPLG7, GLC1M, LERK7, RAGS

Human Chr (Location): 5q21; chr5:107376889-107670895 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit abnormalities in establishing correct axonal connections involving the retinal, motor, vomeronasal, and tactile axons to their respective targets. Some mutants develop neural tube defects.
 
Human Diseases Modeled in Mice Using Efna5 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Efna5 interacts with 419 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (81 records)
Data Summary: Results (252)    Tissues (206)    Images (66)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 232
RT-PCR 18
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA EFNA5 ; Xenbase efna5 ; ZFIN efna5b    NEW 
Molecular
reagents
All nucleic(30) cDNA(21) Primer pair(4) Other(5)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000030233 (Evidence)
Ensembl Gene Model ENSMUSG00000048915 (Evidence)
Entrez Gene 13640 (Evidence)
DFCI TC1705319, TC1591267, TC1579647, TC1748988, TC1750802
DoTS DT.40165783, DT.489542, DT.97394292, DT.91329204
NIA Mouse Gene Index U064037, U037990
PDB 1SHX, 1SHW
Consensus CDS Project CCDS28934.1, CCDS28935.1
International Mouse Phenotyping Consortium Status Efna5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030233 VEGA Gene Model | MGI Sequence Detail 277134 C57BL/6J ±  kb
transcript OTTMUST00000074850 VEGA | MGI Sequence Detail 4032 Not Applicable 
polypeptide OTTMUSP00000039127 VEGA | MGI Sequence Detail 228 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(10) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(1445 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008972 Cupredoxin
InterPro IPR001799 Ephrin
InterPro IPR019765 Ephrin, conserved site
Protein Ontology PR:000006920 ephrin-A5
References
(Earliest) J:34141 Cerretti DP, et al., The gene encoding LERK-7 (EPLG7, Epl7), a ligand for the Eph-related receptor tyrosine kinases, maps to human chromosome 5 at band q21 and to mouse chromosome 17. Genomics. 1996 Jul 15;35(2):376-9
(Latest) J:217584 Gerstmann K, et al., Thalamic afferents influence cortical progenitors via ephrin A5-EphA4 interactions. Development. 2015 Jan 1;142(1):140-50
All references(153)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-35915, MGI:2147024

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory