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Efna5
Gene Detail
Symbol

Name
ID
Efna5
ephrin A5
MGI:107444
Synonyms
AL-1, EFL-5, Ephrin-A5, Epl7, LERK-7, RAGS
Feature Type
protein coding gene
Genetic Map
Chromosome 17
32.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:62604184-62881317 bp, - strand
From VEGA annotation of GRCm38

  277134 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1482  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Ephrin-A

Human
homologs
Human Homolog EFNA5, ephrin-A5
NCBI Gene ID 1946
neXtProt AC  NX_P52803
Human Synonyms  AF1, EFL5, EPLG7, GLC1M, LERK7, RAGS
Human Chr (Location)  5q21; chr5:107376889-107670895 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit abnormalities in establishing correct axonal connections involving the retinal, motor, vomeronasal, and tactile axons to their respective targets. Some mutants develop neural tube defects.
 
Human Diseases Modeled Using Mouse Efna5 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Efna5 interacts with 420 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (79 records)
Data Summary: Results (252)    Tissues (206)    Images (66)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 232
RT-PCR 18
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) cDNA(20) Primer pair(4) Other(5)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000030233 (Evidence)
Ensembl Gene ModelENSMUSG00000090425 (Evidence), ENSMUSG00000048915 (Evidence)
Entrez Gene13640 (Evidence)
DFCITC1750802, TC1748988, TC1591267, TC1579647
DoTSDT.40165783, DT.91329204, DT.489542
NIA Mouse Gene IndexU037990
PDB1SHX, 1SHW
Consensus CDS ProjectCCDS28934.1, CCDS28935.1
International Mouse Knockout Project StatusEfna5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030233 VEGA Gene Model | MGI Sequence Detail 277134 C57BL/6J ±  kb
transcript OTTMUST00000074850 VEGA | MGI Sequence Detail 4032 Not Applicable 
polypeptide OTTMUSP00000039127 VEGA | MGI Sequence Detail 228 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(14) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(1445 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008972 Cupredoxin
InterPro IPR001799 Ephrin
InterPro IPR019765 Ephrin, conserved site
Protein Ontology PR:000006920 ephrin-A5
References
(Earliest) J:34141 Cerretti DP, et al., The gene encoding LERK-7 (EPLG7, Epl7), a ligand for the Eph-related receptor tyrosine kinases, maps to human chromosome 5 at band q21 and to mouse chromosome 17. Genomics. 1996 Jul 15;35(2):376-9
(Latest) J:213589 Ono K, et al., Development of the prethalamus is crucial for thalamocortical projection formation and is regulated by Olig2. Development. 2014 May;141(10):2075-84
All references(150)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-35915, MGI:2147024

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory