Efna5
Gene Detail

Symbol Name ID

Efna5 ephrin A5 MGI:107444

Synonyms

AL-1, EFL-5, Ephrin-A5, Epl7, LERK-7, RAGS

Feature Type

protein coding gene

Genetic Map

Chromosome 17

32.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr17:62604184-62881317 bp, - strand From VEGA annotation of GRCm38   277134 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1482  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Ephrin-A

Human homologs

Human Homolog		EFNA5, ephrin-A5
NCBI Gene ID		1946
neXtProt AC		NX_P52803
Human Synonyms		AF1, EFL5, EPLG7, GLC1M, LERK7, RAGS
Human Chr (Location)		5q21; chr5:106712590-107006596 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(4) Gene trapped(2)
 

Homozygotes for targeted null mutations exhibit abnormalities in establishing correct axonal connections involving the retinal, motor, vomeronasal, and tactile axons to their respective targets. Some mutants develop neural tube defects.

 
Human Diseases Modeled Using Mouse Efna5 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	axon guidance, brain development, ...
Component	anchored to external side of plasma membrane, anchored to membrane, ...
Function	chemorepellent activity, ephrin receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (74 records)
Data Summary: Results (218)    Tissues (169)    Images (56)
Theiler Stages: 13, 17, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	210
RT-PCR	8

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(26) cDNA(20) Primer pair(2) Other(4)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000030233 (Evidence)
Ensembl Gene Model	ENSMUSG00000048915 (Evidence), ENSMUSG00000090425 (Evidence)
Entrez Gene	13640 (Evidence)
DFCI	TC1579647, TC1591267, TC1748988, TC1750802
DoTS	DT.40165783, DT.489542, DT.91329204
NIA Mouse Gene Index	U037990
PDB	1SHW, 1SHX
Consensus CDS Project	CCDS28934.1, CCDS28935.1
International Mouse Knockout Project Status	Efna5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030233	VEGA Gene Model | MGI Sequence Detail	277134	C57BL/6J
transcript	OTTMUST00000074850	VEGA | MGI Sequence Detail	4032	Not Applicable
polypeptide	OTTMUSP00000039127	VEGA | MGI Sequence Detail	228	Not Applicable

All sequences(41) RefSeq(4) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(1304 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008972	Cupredoxin
InterPro	IPR001799	Ephrin
InterPro	IPR019765	Ephrin, conserved site
Protein Ontology	PR:000006920	ephrin-A5

References

(Earliest) J:34141 Cerretti DP, et al., The gene encoding LERK-7 (EPLG7, Epl7), a ligand for the Eph-related receptor tyrosine kinases, maps to human chromosome 5 at band q21 and to mouse chromosome 17. Genomics. 1996 Jul 15;35(2):376-9
(Latest) J:193948 Sheleg M, et al., Ephrin-A5 deficiency alters sensorimotor and monoaminergic development. Behav Brain Res. 2013 Jan 1;236(1):139-47
All references(138)

Other accession IDs

MGD-MRK-35915, MGI:2147024