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Cep131 Gene Detail
Summary
  • Symbol
    Cep131
  • Name
    centrosomal protein 131
  • Synonyms
    AZ1, Azi1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107440
    NCBI Gene: 12009
  • Gene Overview
    MyGene.info: CEP131
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120064430-120086827 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 83.96 cM, cytoband E2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    81 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107440
protein coding gene Chr11:120064429-120086861 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019489
protein coding gene Chr11:124497554-124521592 (-)
A/J MGP_AJ_G0019457
protein coding gene Chr11:118966589-118990207 (-)
AKR/J MGP_AKRJ_G0019427
protein coding gene Chr11:122546137-122568382 (-)
BALB/cJ MGP_BALBcJ_G0019432
protein coding gene Chr11:119324073-119346820 (-)
C3H/HeJ MGP_C3HHeJ_G0019238
protein coding gene Chr11:122868289-122891631 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019881
protein coding gene Chr11:128267240-128294788 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017506
protein coding gene Chr11:115970019-115993582 (-)
CAST/EiJ MGP_CASTEiJ_G0018792
protein coding gene Chr11:124346273-124373569 (-)
CBA/J MGP_CBAJ_G0019209
protein coding gene Chr11:133280958-133309534 (-)
DBA/2J MGP_DBA2J_G0019321
protein coding gene Chr11:118333628-118356205 (-)
FVB/NJ MGP_FVBNJ_G0019313
protein coding gene Chr11:118023040-118046091 (-)
LP/J MGP_LPJ_G0019393
protein coding gene Chr11:124807538-124831224 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019346
protein coding gene Chr11:132150065-132172365 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019920
protein coding gene Chr11:123229649-123252121 (-)
PWK/PhJ MGP_PWKPhJ_G0018558
protein coding gene Chr11:119761249-119784656 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018350
protein coding gene Chr11:122994869-123021981 (-)
WSB/EiJ MGP_WSBEiJ_G0018844
protein coding gene Chr11:123224009-123249294 (-)



Homology
more
  • Human Ortholog
    CEP131, centrosomal protein 131
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CEP131, centrosomal protein 131
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AZ1, AZI1, ZA1
  • Links
    NCBI Gene ID: 22994
    neXtProt AC: NX_Q9UPN4
    UniProt: Q9UPN4

  • Chr Location
    17q25.3; chr17:81189593-81222989 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7638
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CEP131
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit partial preweaning lethality with no apparent defects in cilia formation or function. However, homozygotes display complete male infertility associated with spermiogenesis arrest, severe flagellar defects, and teratozoospermia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039781 Ensembl Gene Model | MGI Sequence Detail 22398 C57BL/6J ±  kb
transcript ENSMUST00000106229 Ensembl | MGI Sequence Detail 3581 Not Applicable  
polypeptide ENSMUSP00000101836 Ensembl | MGI Sequence Detail 1060 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    Genomic 3
    cDNA 31

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35911
References
more
  • Summaries
    All 31
    Gene Ontology 8
    Phenotypes 8
  • Earliest
    J:30050 Aoto H, et al., Isolation of a novel cDNA that encodes a protein localized to the pre-acrosome region of spermatids. Eur J Biochem. 1995 Nov 15;234(1):8-15
  • Latest
    J:207969 Chamling X, et al., The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome. PLoS Genet. 2014 Feb;10(2):e1004083

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory