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Cdh6 Gene Detail
Summary
  • Symbol
    Cdh6
  • Name
    cadherin 6
  • Synonyms
    cad6, K-cadherin
  • Feature Type
    protein coding gene
  • IDs
    MGI:107435
    NCBI Gene: 12563
  • Gene Overview
    MyGene.info: CDH6
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:13028701-13173675 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 6.11 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1218 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107435
protein coding gene Chr15:13028699-13176476 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021741
protein coding gene Chr15:10288820-10429525 (-)
A/J MGP_AJ_G0021701
protein coding gene Chr15:9976206-10119259 (-)
AKR/J MGP_AKRJ_G0021679
protein coding gene Chr15:10260667-10404541 (-)
BALB/cJ MGP_BALBcJ_G0021708
protein coding gene Chr15:9884632-10026347 (-)
C3H/HeJ MGP_C3HHeJ_G0021484
protein coding gene Chr15:10199410-10350120 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022147
protein coding gene Chr15:10648213-10809434 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019688
protein coding gene Chr15:9490283-9550536 (-)
CAST/EiJ MGP_CASTEiJ_G0021000
protein coding gene Chr15:10313262-10452144 (-)
CBA/J MGP_CBAJ_G0021453
protein coding gene Chr15:10981182-11137073 (-)
DBA/2J MGP_DBA2J_G0021577
protein coding gene Chr15:9826003-9972630 (-)
FVB/NJ MGP_FVBNJ_G0021555
protein coding gene Chr15:9678540-9824808 (-)
LP/J MGP_LPJ_G0021645
protein coding gene Chr15:10228092-10367917 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021580
protein coding gene Chr15:11178210-11326943 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022170
protein coding gene Chr15:10247058-10392194 (-)
PWK/PhJ MGP_PWKPhJ_G0020743
protein coding gene Chr15:10022709-10163069 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020581
protein coding gene Chr15:10196349-10338052 (-)
WSB/EiJ MGP_WSBEiJ_G0021056
protein coding gene Chr15:10231574-10373132 (-)



Homology
more
  • Human Ortholog
    CDH6, cadherin 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CDH6, cadherin 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAD6, KCAD
  • Links
    NCBI Gene ID: 1004
    neXtProt AC: NX_P55285
    UniProt: P55285

  • Chr Location
    5p13.3; chr5:31193655-31329146 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 21027
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CDH6
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit delayed mesenchyme to epithelial conversion and loss of nephrons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039385 Ensembl Gene Model | MGI Sequence Detail 144975 C57BL/6J ±  kb
    transcript ENSMUST00000036439 Ensembl | MGI Sequence Detail 8167 Not Applicable  
    polypeptide ENSMUSP00000037113 Ensembl | MGI Sequence Detail 790 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 26
      Primer pair 6
      Other 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35906
    References
    more
    • Summaries
      All 130
      Developmental Gene Expression 87
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:32957 Munro SB, et al., Characterization of cadherins expressed by murine thymocytes. Cell Immunol. 1996 May 1;169(2):309-12
    • Latest
      J:265843 Chowdhury R, et al., The Trim family of genes and the retina: Expression and functional characterization. PLoS One. 2018;13(9):e0202867

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory