About   Help   FAQ
Cdh8
Gene Detail
 Symbol
Name
ID
Cdh8
cadherin 8
MGI:107434
Synonyms cad8
Feature Type protein coding gene
Genetic Map
Chromosome 8
49.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:99024471-99416471 bp, - strand
From VEGA annotation of GRCm38

  392001 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55604  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cadherin
Gene Tree: Cdh8

Human
homologs
Human Homolog CDH8, cadherin 8, type 2
NCBI Gene ID 1006
neXtProt AC  NX_P55286
Human Synonyms  Nbla04261
Human Chr (Location)  16q22.1; chr16:61647265-62037035 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele are viable, fertile and overtly normal but display abnormal CNS synaptic transmission, raise their tails in response to stress, and show reduced sensitivity to cutaneous cold stimuli.
 
Interactions
Cdh8 interacts with 421 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell adhesion, homophilic cell adhesion, ...
Component axon terminus, integral component of membrane, ...
Function calcium ion binding, metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (70 records)
Data Summary: Results (453)    Tissues (203)    Images (67)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 442
RT-PCR 11
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) cDNA(27) Primer pair(3) Other(3)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000025221 (Evidence)
Ensembl Gene ModelENSMUSG00000036510 (Evidence)
Entrez Gene12564 (Evidence)
UniGene441131
DFCITC1583403, TC1589725, TC1594632
DoTSDT.102554673, DT.110900466, DT.110900507, DT.60100085, DT.87048901
NIA Mouse Gene IndexU030145
PDB1ZXK, 2A62
Consensus CDS ProjectCCDS22569.1, CCDS40448.1, CCDS72155.1, CCDS72156.1
International Mouse Knockout Project StatusCdh8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025221 VEGA Gene Model | MGI Sequence Detail 392001 C57BL/6J ±  kb
transcript OTTMUST00000062079 VEGA | MGI Sequence Detail 4594 Not Applicable 
polypeptide OTTMUSP00000030554 VEGA | MGI Sequence Detail 799 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(16) UniProt(9)
Polymorphisms RFLP(1) : SNPs within 2kb(3102 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR000233 Cadherin, cytoplasmic domain
InterPro IPR015919 Cadherin-like
InterPro IPR027397 Catenin binding domain
Protein Ontology PR:000005249 cadherin-8
References (Earliest) J:32957 Munro SB, et al., Characterization of cadherins expressed by murine thymocytes. Cell Immunol. 1996 May 1;169(2):309-12
(Latest) J:205196 Shetty AS, et al., Lhx2 regulates a cortex-specific mechanism for barrel formation. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4913-21
All references(99)
Other
accession IDs
MGD-MRK-35905, MGI:2142634

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory