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Cdh8 Gene Detail
Summary
  • Symbol
    Cdh8
  • Name
    cadherin 8
  • Synonyms
    cad8
  • Feature Type
    protein coding gene
  • IDs
    MGI:107434
    NCBI Gene: 12564
  • Gene Overview
    MyGene.info: CDH8
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:99024471-99416471 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 49.40 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3088 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107434
protein coding gene Chr8:99024471-99416486 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033996
protein coding gene Chr8:100693094-101102137 (-)
A/J MGP_AJ_G0033979
protein coding gene Chr8:96747163-97150328 (-)
AKR/J MGP_AKRJ_G0033905
protein coding gene Chr8:99403793-99818311 (-)
BALB/cJ MGP_BALBcJ_G0033971
protein coding gene Chr8:96846405-97238477 (-)
C3H/HeJ MGP_C3HHeJ_G0033681
protein coding gene Chr8:100190117-100596148 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034492
protein coding gene Chr8:104373361-104790845 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031434
protein coding gene Chr8:90479290-90869036 (-)
CAST/EiJ MGP_CASTEiJ_G0033013
protein coding gene Chr8:99692431-100122112 (-)
CBA/J MGP_CBAJ_G0033657
protein coding gene Chr8:107902617-108345571 (-)
DBA/2J MGP_DBA2J_G0033811
protein coding gene Chr8:96206960-96602794 (-)
FVB/NJ MGP_FVBNJ_G0033758
protein coding gene Chr8:95115393-95509451 (-)
LP/J MGP_LPJ_G0033903
protein coding gene Chr8:100802026-101218922 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033800
protein coding gene Chr8:110410571-110919967 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034510
protein coding gene Chr8:99581972-99978745 (-)
PWK/PhJ MGP_PWKPhJ_G0032715
protein coding gene Chr8:95620318-96023609 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032552
protein coding gene Chr8:98415399-98834281 (-)
WSB/EiJ MGP_WSBEiJ_G0033125
protein coding gene Chr8:100081610-100494463 (-)



Homology
more
  • Human Ortholog
    CDH8, cadherin 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CDH8, cadherin 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Nbla04261
  • Links
    NCBI Gene ID: 1006
    neXtProt AC: NX_P55286
    UniProt: P55286

  • Chr Location
    16q21; chr16:61640435-62036835 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable, fertile and overtly normal but display abnormal CNS synaptic transmission, raise their tails in response to stress, and show reduced sensitivity to cutaneous cold stimuli.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036510 Ensembl Gene Model | MGI Sequence Detail 392001 C57BL/6J ±  kb
    transcript ENSMUST00000128860 Ensembl | MGI Sequence Detail 4594 Not Applicable  
    polypeptide ENSMUSP00000117326 Ensembl | MGI Sequence Detail 799 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 31
      Primer pair 7
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-35905, MGI:2142634
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 89
      Gene Ontology 8
      Phenotypes 6
    • Earliest
      J:32957 Munro SB, et al., Characterization of cadherins expressed by murine thymocytes. Cell Immunol. 1996 May 1;169(2):309-12
    • Latest
      J:264703 Liu J, et al., Tbr1 instructs laminar patterning of retinal ganglion cell dendrites. Nat Neurosci. 2018 May;21(5):659-670

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory