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Cdh8
Gene Detail
Symbol

Name
ID
Cdh8
cadherin 8
MGI:107434
Synonyms
cad8
Feature Type
protein coding gene
Genetic Map
Chromosome 8
49.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:99024471-99416471 bp, - strand
From VEGA annotation of GRCm38

  392001 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55604  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDH8
Protein SuperFamily: cadherin
Gene Tree: Cdh8

Human
homologs
CDH8, cadherin 8, type 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1006
neXtProt AC: NX_P55286

Human Synonyms: Nbla04261

Human Chr (Location): 16q22.1; chr16:61647244-62037035 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele are viable, fertile and overtly normal but display abnormal CNS synaptic transmission, raise their tails in response to stress, and show reduced sensitivity to cutaneous cold stimuli.
 
Interactions
Cdh8 interacts with 420 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (73 records)
Data Summary: Results (453)    Tissues (203)    Images (67)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 442
RT-PCR 11
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CDH8 ; Xenbase cdh8    NEW 
Molecular
reagents
All nucleic(33) cDNA(27) Primer pair(3) Other(3)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000025221 (Evidence)
Ensembl Gene Model ENSMUSG00000036510 (Evidence)
Entrez Gene 12564 (Evidence)
UniGene 441131
DFCI TC1583403, TC1589725, TC1594632
DoTS DT.102554673, DT.110900466, DT.110900507, DT.60100085, DT.87048901
NIA Mouse Gene Index U030145
PDB 1ZXK, 2A62
Consensus CDS Project CCDS22569.1, CCDS40448.1, CCDS72155.1, CCDS72156.1
International Mouse Phenotyping Consortium Status Cdh8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025221 VEGA Gene Model | MGI Sequence Detail 392001 C57BL/6J ±  kb
transcript OTTMUST00000062079 VEGA | MGI Sequence Detail 4594 Not Applicable 
polypeptide OTTMUSP00000030554 VEGA | MGI Sequence Detail 799 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(12) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(3102 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR000233 Cadherin, cytoplasmic domain
InterPro IPR015919 Cadherin-like
InterPro IPR027397 Catenin binding domain
Protein Ontology PR:000005249 cadherin-8
References
(Earliest) J:32957 Munro SB, et al., Characterization of cadherins expressed by murine thymocytes. Cell Immunol. 1996 May 1;169(2):309-12
(Latest) J:213614 Hirata-Fukae C, et al., The zinc finger gene Fezf2 is required for the development of excitatory neurons in the basolateral complex of the amygdala. Dev Dyn. 2014 Aug;243(8):1030-6
All references(100)
Other
accession IDs
MGD-MRK-35905, MGI:2142634

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory