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Drp2 Gene Detail
Summary
  • Symbol
    Drp2
  • Name
    dystrophin related protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107432
    NCBI Gene: 13497
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:134404551-134456573 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 56.18 cM, cytoband E3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    162 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107432
 protein coding gene ChrX:134404124-134456574 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036067
 protein coding gene ChrX:131584203-131636819 (+)
A/J MGP_AJ_G0036049
 protein coding gene ChrX:130997703-131052119 (+)
AKR/J MGP_AKRJ_G0035968
 protein coding gene ChrX:135202999-135258676 (+)
BALB/cJ MGP_BALBcJ_G0036040
 protein coding gene ChrX:129433024-129485537 (+)
C3H/HeJ MGP_C3HHeJ_G0035744
 protein coding gene ChrX:131653225-131713200 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036562
 protein coding gene ChrX:135454875-135509227 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033390
 protein coding gene ChrX:123185644-123237830 (+)
CAST/EiJ MGP_CASTEiJ_G0035031
 protein coding gene ChrX:112527376-112587154 (+)
CBA/J MGP_CBAJ_G0035721
 protein coding gene ChrX:139519253-139576484 (+)
DBA/2J MGP_DBA2J_G0035874
 protein coding gene ChrX:130316399-130368453 (+)
FVB/NJ MGP_FVBNJ_G0035816
 protein coding gene ChrX:129633089-129688676 (+)
LP/J MGP_LPJ_G0035967
 protein coding gene ChrX:132456865-132510851 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035844
 protein coding gene ChrX:146883378-146939097 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036591
 protein coding gene ChrX:131005552-131060871 (+)
PWK/PhJ MGP_PWKPhJ_G0034723
 protein coding gene ChrX:109476252-109528104 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034555
 protein coding gene ChrX:113164063-113219315 (+)
WSB/EiJ MGP_WSBEiJ_G0035168
 protein coding gene ChrX:129379451-129434510 (+)



Homology
more
  • Human Ortholog
    DRP2, dystrophin related protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DRP2, dystrophin related protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DRP-2
  • Links
    NCBI Gene ID: 1821
    neXtProt AC: NX_Q13474
    UniProt: Q13474

  • Chr Location
    Xq22.1; chrX:101219786-101264497 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in peripheral nerves exhibit abnormal Scwann cell morphology, supernumerary Schwann cell, abnormal myelin sheath morphology and hypermyelination.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    769
  • Tissues
    45
  • cDNA Data
    25
  • Literature Summary
    6
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000223 Ensembl Gene Model | MGI Sequence Detail 52023 C57BL/6J ±  kb
transcript ENSMUST00000113224 Ensembl | MGI Sequence Detail 4147 Not Applicable  
polypeptide ENSMUSP00000108850 Ensembl | MGI Sequence Detail 981 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    cDNA 26
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-35903, MGI:2148013
References
more
  • Summaries
    All 36
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:33275 Roberts RG, et al., Characterization of DRP2, a novel human dystrophin homologue. Nat Genet. 1996 Jun;13(2):223-6
  • Latest
    J:288683 Gacem N, et al., ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development. Nat Commun. 2020 Jan 10;11(1):198
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
01/12/2021
MGI 6.16 		The Jackson Laboratory