Drp2 MGI Mouse Gene Detail - MGI:107432 - dystrophin related protein 2

Symbol

Drp2
Name

dystrophin related protein 2

Feature Type

protein coding gene
IDs

MGI:107432
NCBI Gene: 13497
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

ChrX:133305300-133357322 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 56.18 cM, cytoband E3
Mapping Data

3 experiments

SNPs within 2kb

160 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107432	protein coding gene	ChrX:133304873-133357323 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0036067	protein coding gene	ChrX:131584203-131636819 (+)
A/J	MGP_AJ_G0036049	protein coding gene	ChrX:130997703-131052119 (+)
AKR/J	MGP_AKRJ_G0035968	protein coding gene	ChrX:135202999-135258676 (+)
BALB/cJ	MGP_BALBcJ_G0036040	protein coding gene	ChrX:129433024-129485537 (+)
C3H/HeJ	MGP_C3HHeJ_G0035744	protein coding gene	ChrX:131653225-131713200 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036562	protein coding gene	ChrX:135454875-135509227 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033390	protein coding gene	ChrX:123185644-123237830 (+)
CAST/EiJ	MGP_CASTEiJ_G0035031	protein coding gene	ChrX:112527376-112587154 (+)
CBA/J	MGP_CBAJ_G0035721	protein coding gene	ChrX:139519253-139576484 (+)
DBA/2J	MGP_DBA2J_G0035874	protein coding gene	ChrX:130316399-130368453 (+)
FVB/NJ	MGP_FVBNJ_G0035816	protein coding gene	ChrX:129633089-129688676 (+)
LP/J	MGP_LPJ_G0035967	protein coding gene	ChrX:132456865-132510851 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035844	protein coding gene	ChrX:146883378-146939097 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036591	protein coding gene	ChrX:131005552-131060871 (+)
PWK/PhJ	MGP_PWKPhJ_G0034723	protein coding gene	ChrX:109476252-109528104 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034555	protein coding gene	ChrX:113164063-113219315 (+)
WSB/EiJ	MGP_WSBEiJ_G0035168	protein coding gene	ChrX:129379451-129434510 (+)

Human Ortholog

DRP2, dystrophin related protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DRP2, dystrophin related protein 2
Synonyms

DRP-2
Links

HGNC:3032

NCBI Gene ID: 1821

neXtProt AC: NX_Q13474

UniProt: Q13474
Chr Location

Xq22.1; chrX:101219786-101264497 (+) GRCh38.p7

Alliance of Genome Resources

Drp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DRP2
Protein SuperFamily

Dystrophin-related_p2
Gene Tree

Drp2

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Incidental Mutations

Mutagenetix , CvDC
Find Mice (IMSR)

12 strains or lines available

Mice homozygous for a conditional allele activated in peripheral nerves exhibit abnormal Scwann cell morphology, supernumerary Schwann cell, abnormal myelin sheath morphology and hypermyelination.

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

844
Tissues

45
cDNA Data

25
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase drp2

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Drp2 interacts with 403 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

70
RefSeq

24
UniProt

3
CCDS

CCDS30394.1

Ensembl

ENSMUSG00000000223 (Evidence)
NCBI Gene

13497

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000223	Ensembl Gene Model \| MGI Sequence Detail	52023	C57BL/6J	± kb
transcript	ENSMUST00000113224	Ensembl \| MGI Sequence Detail	4147	Not Applicable
polypeptide	ENSMUSP00000108850	Ensembl \| MGI Sequence Detail	981	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006691 dystrophin-related protein 2

(term hierarchy)
InterPro Domains

IPR017433 Dystrophin-related protein 2

IPR011992 EF-hand domain pair

IPR015153 EF-hand domain, type 1

IPR015154 EF-hand domain, type 2

IPR018159 Spectrin/alpha-actinin

IPR002017 Spectrin repeat

IPR001202 WW domain

IPR036020 WW domain superfamily

IPR000433 Zinc finger, ZZ-type

IPR043145 Zinc finger, ZZ-type superfamily

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All nucleic 27

cDNA 26

Primer pair 1

Microarray probesets 5

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MGD-MRK-35903, MGI:2148013

Summaries

All 37

Developmental Gene Expression 6

Gene Ontology 5

Phenotypes 4
Earliest

J:33275 Roberts RG, et al., Characterization of DRP2, a novel human dystrophin homologue. Nat Genet. 1996 Jun;13(2):223-6
Latest

J:288683 Gacem N, et al., ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development. Nat Commun. 2020 Jan 10;11(1):198

TSS for Drp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161993	ChrX:133305292-133305338 (+)	15 bp
Tssr161994	ChrX:133305557-133305646 (+)	302 bp
Tssr161995	ChrX:133325970-133325985 (+)	20,678 bp
Tssr161996	ChrX:133327768-133327778 (+)	22,473 bp
Tssr161997	ChrX:133327784-133327803 (+)	22,494 bp
Tssr161998	ChrX:133327805-133327828 (+)	22,517 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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