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Il11ra1
Gene Detail
Symbol

Name
ID
Il11ra1
interleukin 11 receptor, alpha chain 1
MGI:107426
Synonyms
Il11ra, Il-11ra, Il-11ra-alpha, NR1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
21.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:41699989-41769474 bp, + strand
From VEGA annotation of GRCm38

  69486 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88705  Vertebrate Homology Class
1 human; 4 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ciliary neurotrophic factor receptor-like protein
Gene Tree: Il11ra1

Human
homologs
Human Homolog IL11RA, interleukin 11 receptor, alpha
NCBI Gene ID 3590
neXtProt AC  NX_Q14626
Human Synonyms  CRSDA
Human Chr (Location)  9p13; chr9:34652185-34661902 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human IL11RA
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Female homozygotes for targeted null mutations are infertile due to defective decidua formation.
 
Interactions
Il11ra1 interacts with 50 markers (Mir1a-2, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cytokine-mediated signaling pathway, decidualization, ...
Component integral component of membrane, membrane
Function cytokine receptor activity, interleukin-11 binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (528)    Tissues (37)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 461
Northern blot 24
RT-PCR 42
Nuclease S1 1
cDNA source data(104)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(119) Genomic(6) cDNA(108) Primer pair(3) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006681 (Evidence)
Ensembl Gene ModelENSMUSG00000073889 (Evidence)
Entrez Gene16157 (Evidence)
UniGene193451
Consensus CDS ProjectCCDS18071.1
International Mouse Knockout Project StatusIl11ra1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006681 VEGA Gene Model | MGI Sequence Detail 69486 C57BL/6J ±  kb
transcript OTTMUST00000015311 VEGA | MGI Sequence Detail 1768 Not Applicable 
polypeptide OTTMUSP00000007072 VEGA | MGI Sequence Detail 432 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(468 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013151 Immunoglobulin
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003530 Long hematopoietin receptor, soluble alpha chain, conserved site
Protein Ontology PR:000034875 interleukin-11 receptor subunit alpha-1
References
(Earliest) J:21233 Hilton DJ, et al., Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction. EMBO J. 1994 Oct 17;13(20):4765-75
(Latest) J:202609 Putoczki TL, et al., Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer Cell. 2013 Aug 12;24(2):257-71
All references(58)
Other
accession IDs
MGD-MRK-35897, MGI:3034462

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory