Il11ra1
Gene Detail

Symbol Name ID

Il11ra1 interleukin 11 receptor, alpha chain 1 MGI:107426

Synonyms

Il11ra, Il-11ra, Il-11ra-alpha, NR1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

21.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr4:41699989-41769474 bp, + strand From VEGA annotation of GRCm38   69486 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:88705  Vertebrate Homology Class
1 human; 4 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ciliary neurotrophic factor receptor-like protein
Gene Tree: Il11ra1

Human homologs

Human Homolog		IL11RA, interleukin 11 receptor, alpha
NCBI Gene ID		3590
neXtProt AC		NX_Q14626
Human Synonyms		CRSDA
Human Chr (Location)		9p13; chr9:34652182-34661899 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human IL11RA

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Female homozygotes for targeted null mutations are infertile due to defective decidua formation.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	cytokine-mediated signaling pathway, decidualization, ...
Component	integral to membrane, membrane
Function	cytokine receptor activity, interleukin-11 binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (528)    Tissues (37)    Images (48)
Theiler Stages: 17, 20, 23, 26, 28

Assay Type	Results
RNA in situ	461
Northern blot	24
RT-PCR	42
Nuclease S1	1

cDNA source data(104)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(119) Genomic(6) cDNA(108) Primer pair(3) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000006681 (Evidence)
Ensembl Gene Model	ENSMUSG00000073889 (Evidence)
Entrez Gene	16157 (Evidence)
UniGene	193451
Consensus CDS Project	CCDS18071.1
International Mouse Knockout Project Status	Il11ra1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006681	VEGA Gene Model | MGI Sequence Detail	69486	C57BL/6J
transcript	OTTMUST00000015311	VEGA | MGI Sequence Detail	1768	Not Applicable
polypeptide	OTTMUSP00000007072	VEGA | MGI Sequence Detail	432	Not Applicable

All sequences(58) RefSeq(6) UniProt(3)

Polymorphisms

SNPs(22 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013151	Immunoglobulin
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003530	Long hematopoietin receptor, soluble alpha chain, conserved site
Protein Ontology	PR:000034875	interleukin-11 receptor subunit alpha-1

References

(Earliest) J:21233 Hilton DJ, et al., Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction. EMBO J. 1994 Oct 17;13(20):4765-75
(Latest) J:192468 Gu D, et al., A role for transcription factor STAT3 signaling in oncogene smoothened-driven carcinogenesis. J Biol Chem. 2012 Nov 2;287(45):38356-66
All references(55)

Other accession IDs

MGD-MRK-35897, MGI:3034462