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Hspa4l Gene Detail
Summary
  • Symbol
    Hspa4l
  • Name
    heat shock protein 4 like
  • Synonyms
    94kDa, APG-1, Osp94
  • Feature Type
    protein coding gene
  • IDs
    MGI:107422
    NCBI Gene: 18415
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:40699814-40750538 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 19.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1191 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107422
 protein coding gene Chr3:40698664-40750538 (+)
129S1/SvImJ ENSMUSG00200005711
 protein coding gene Chr3:37443411-37494138 (+)
A/J ENSMUSG00195001389
 protein coding gene Chr3:37427835-37478531 (+)
AKR/J ENSMUSG00220000346
 protein coding gene Chr3:37509653-37560379 (+)
BALB/cJ ENSMUSG00180002285
 protein coding gene Chr3:37554965-37605635 (+)
C3H/HeJ ENSMUSG00175003109
 protein coding gene Chr3:37425708-37476413 (+)
C57BL/6NJ ENSMUSG00215001481
 protein coding gene Chr3:37837392-37888122 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024958
 protein coding gene Chr3:35328037-35383555 (+)
CAST/EiJ ENSTCUG00005000888
 protein coding gene Chr3:37286945-37337710 (+)
CBA/J ENSMUSG00210001107
 protein coding gene Chr3:37521102-37571834 (+)
DBA/2J ENSMUSG00185001103
 protein coding gene Chr3:37717746-37768412 (+)
FVB/NJ ENSMUSG00205000450
 protein coding gene Chr3:36837143-36887831 (+)
JF1/MsJ ENSUMUG00000000484
 protein coding gene Chr3:37212363-37263183 (+)
LP/J ENSMUSG00230020804
 protein coding gene Chr3:39684401-39735125 (+)
NOD/ShiLtJ ENSMUSG00190001090
 protein coding gene Chr3:37774983-37825660 (+)
NZO/HlLtJ ENSMUSG00225000401
 protein coding gene Chr3:42305338-42356060 (+)
PWK/PhJ ENSLUMG00010000628
 protein coding gene Chr3:37255989-37306980 (+)
SPRET/EiJ ENSMSPG00010000533
 protein coding gene Chr3:37721985-37773705 (+)
WSB/EiJ ENSIUOG00005013360
 protein coding gene Chr3:37694149-37744826 (+)



Homology
more
  • Human Ortholog
    HSPA4L, heat shock protein family A (Hsp70) member 4 like
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSPA4L, heat shock protein family A (Hsp70) member 4 like
  • Synonyms
    APG-1, APG1, HSPH3, Osp94
  • Links
    NCBI Gene ID: 22824
    UniProt: O95757

  • Chr Location
    4q28.1; chr4:127781796-127840733 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display increased incidence of male infertility, due to reduced number of mature sperm and reduced sperm motility, and hydronephrosis development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    906
  • Tissues
    91
  • cDNA Data
    79
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025757 Ensembl Gene Model | MGI Sequence Detail 50725 C57BL/6J ±  kb
    transcript ENSMUST00000204702 Ensembl | MGI Sequence Detail 9479 Not Applicable  
    polypeptide ENSMUSP00000145468 Ensembl | MGI Sequence Detail 838 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000008809 heat shock 70 kDa protein 4L
      (term hierarchy)
    • InterPro Domains
      IPR043129 ATPase, nucleotide binding domain
      IPR018181 Heat shock protein 70, conserved site
      IPR013126 Heat shock protein 70 family
      IPR029048 Heat shock protein 70kD, C-terminal domain superfamily
      IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
      IPR042708 HSPA4L, nucleotide-binding domain
      IPR060486 HYOU1-like, C-terminal domain
    • GlyGen
      P48722 4 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 83
      Genomic 1
      cDNA 79
      Primer pair 3
      Antibodies 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-35892, MGI:2139728
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory