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Hspa4l Gene Detail
Summary
  • Symbol
    Hspa4l
  • Name
    heat shock protein 4 like
  • Synonyms
    94kDa, APG-1, Osp94
  • Feature Type
    protein coding gene
  • IDs
    MGI:107422
    NCBI Gene: 18415
  • Gene Overview
    MyGene.info: HSPA4L
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:40744495-40796103 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 19.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    196 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107422
protein coding gene Chr3:40744404-40796103 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027179
protein coding gene Chr3:38707492-38762562 (+)
A/J MGP_AJ_G0027139
protein coding gene Chr3:37761167-37815237 (+)
AKR/J MGP_AKRJ_G0027108
protein coding gene Chr3:38479745-38532702 (+)
BALB/cJ MGP_BALBcJ_G0027151
protein coding gene Chr3:37515629-37568229 (+)
C3H/HeJ MGP_C3HHeJ_G0026894
protein coding gene Chr3:38564884-38619435 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027597
protein coding gene Chr3:40291253-40351759 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024958
protein coding gene Chr3:35328037-35383555 (+)
CAST/EiJ MGP_CASTEiJ_G0026347
protein coding gene Chr3:38469798-38524458 (+)
CBA/J MGP_CBAJ_G0026871
protein coding gene Chr3:41468117-41521332 (+)
DBA/2J MGP_DBA2J_G0027005
protein coding gene Chr3:37219274-37271775 (+)
FVB/NJ MGP_FVBNJ_G0026973
protein coding gene Chr3:36625641-36677434 (+)
LP/J MGP_LPJ_G0027117
protein coding gene Chr3:39446707-39503085 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026992
protein coding gene Chr3:43910261-43988769 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027656
protein coding gene Chr3:38369315-38422321 (+)
PWK/PhJ MGP_PWKPhJ_G0026080
protein coding gene Chr3:36878718-36931400 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025892
protein coding gene Chr3:37713257-37773087 (+)
WSB/EiJ MGP_WSBEiJ_G0026421
protein coding gene Chr3:38363403-38418250 (+)



Homology
more
  • Human Ortholog
    HSPA4L, heat shock protein family A (Hsp70) member 4 like
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HSPA4L, heat shock protein family A (Hsp70) member 4 like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APG-1, HSPH3, Osp94
  • Links
    NCBI Gene ID: 22824
    neXtProt AC: NX_O95757
    UniProt: O95757

  • Chr Location
    4q28.1; chr4:127781821-127834073 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display increased incidence of male infertility, due to reduced number of mature sperm and reduced sperm motility, and hydronephrosis development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025757 Ensembl Gene Model | MGI Sequence Detail 51609 C57BL/6J ±  kb
    transcript ENSMUST00000204702 Ensembl | MGI Sequence Detail 9479 Not Applicable  
    polypeptide ENSMUSP00000145468 Ensembl | MGI Sequence Detail 838 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000008809 heat shock 70 kDa protein 4L
    • InterPro Domains
      IPR018181 Heat shock protein 70, conserved site
      IPR013126 Heat shock protein 70 family
      IPR029048 Heat shock protein 70kD, C-terminal domain superfamily
      IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 82
      Genomic 1
      cDNA 79
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-35892, MGI:2139728
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:232197 Nagy M, et al., Extended survival of misfolded G85R SOD1-linked ALS mice by transgenic expression of chaperone Hsp110. Proc Natl Acad Sci U S A. 2016 May 10;113(19):5424-8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory