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Hspa4l Gene Detail
Summary
  • Symbol
    Hspa4l
  • Name
    heat shock protein 4 like
  • Synonyms
    94kDa, APG-1, Osp94
  • Feature Type
    protein coding gene
  • IDs
    MGI:107422
    NCBI Gene: 18415
  • Gene Overview
    MyGene.info: HSPA4L
Location & Maps
more
  • Sequence Map
    Chr3:40744495-40796103 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51609 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 19.51 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HSPA4L, heat shock protein family A (Hsp70) member 4 like
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HSPA4L, heat shock protein family A (Hsp70) member 4 like
    Orthology source: HGNC, HomoloGene
  • Synonyms
    APG-1, HSPH3, Osp94
  • Links
    NCBI Gene ID: 22824
    neXtProt AC: NX_O95757

  • Chr Location
    4q28; chr4:127782209-127834073 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Radiation induced
    2
  • Targeted
    5
  • Genomic Mutations
    2 involving Hspa4l
  • Incidental Mutations
Mice homozygous for disruptions in this gene display increased incidence of male infertility, due to reduced number of mature sperm and reduced sperm motility, and hydronephrosis development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023568 VEGA Gene Model | MGI Sequence Detail 51609 C57BL/6J ±  kb
transcript OTTMUST00000057497 VEGA | MGI Sequence Detail 9479 Not Applicable  
polypeptide OTTMUSP00000027739 VEGA | MGI Sequence Detail 838 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    196 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000008809 heat shock 70 kDa protein 4L
  • InterPro Domains
    IPR018181 Heat shock protein 70, conserved site
    IPR013126 Heat shock protein 70 family
    IPR029048 Heat shock protein 70kD, C-terminal domain
    IPR029047 Heat shock protein 70kD, peptide-binding domain
Molecular
Reagents
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  • All nucleic 81
    Genomic 1
    cDNA 78
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-35892, MGI:2139728
References
more
  • Summaries
    All 39
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:33152 Kojima R, et al., Osmotic stress protein 94 (Osp94). A new member of the Hsp110/SSE gene subfamily. J Biol Chem. 1996 May 24;271(21):12327-32
  • Latest
    J:202700 Kern F, et al., Nogo-A couples with Apg-1 through interaction and co-ordinate expression under hypoxic and oxidative stress. Biochem J. 2013 Oct 15;455(2):217-27

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory