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Pcsk7
Gene Detail
 Symbol
Name
ID
Pcsk7
proprotein convertase subtilisin/kexin type 7
MGI:107421
Synonyms SPC7
Feature Type protein coding gene
Genetic Map
Chromosome 9
25.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:45906569-45929692 bp, + strand
From Ensembl annotation of GRCm38

  23124 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37955  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: proprotein convertase subtilisin/kexin type 7
Gene Tree: Pcsk7

Human
homologs
Human Homolog PCSK7, proprotein convertase subtilisin/kexin type 7
NCBI Gene ID 9159
neXtProt AC  NX_Q16549
Human Synonyms  LPC, PC7, PC8, SPC7
Human Chr (Location)  11q23-q24; chr11:117199836-117232525 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit normal response to LPS.
 
Interactions
Pcsk7 interacts with 171 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process protein processing, proteolysis
Component Golgi apparatus, integral component of Golgi membrane, ...
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (6)    Tissues (6)    Images (1)
Theiler Stages: 1, 2, 3, 5, 28
Assay TypeResults
RT-PCR 6
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(11) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000035382 (Evidence)
Entrez Gene18554 (Evidence)
DFCITC1575275, TC1602295, TC1605971
EC3.4.21.-
Consensus CDS ProjectCCDS40609.1
International Mouse Knockout Project StatusPcsk7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035382 Ensembl Gene Model | MGI Sequence Detail 23124 C57BL/6J ±  kb
transcript ENSMUST00000039059 Ensembl | MGI Sequence Detail 3784 Not Applicable 
polypeptide ENSMUSP00000047508 Ensembl | MGI Sequence Detail 770 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(15) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(124 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR000209 Peptidase S8/S53 domain
InterPro IPR022398 Peptidase S8, subtilisin, His-active site
InterPro IPR015500 Peptidase S8, subtilisin-related
InterPro IPR023828 Peptidase S8, subtilisin, Ser-active site
InterPro IPR002884 Proprotein convertase, P
InterPro IPR009020 Proteinase inhibitor, propeptide
Protein Ontology PR:000012439 proprotein convertase subtilisin/kexin type 7
References (Earliest) J:34068 Constam DB, et al., SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis. J Cell Biol. 1996 Jul;134(1):181-91
(Latest) J:201970 Wetsel WC, et al., Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17362-7
All references(33)
Other
accession IDs
MGD-MRK-35891, MGI:2142967

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory