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Pcsk7 Gene Detail
Summary
  • Symbol
    Pcsk7
  • Name
    proprotein convertase subtilisin/kexin type 7
  • Synonyms
    SPC7
  • Feature Type
    protein coding gene
  • IDs
    MGI:107421
    NCBI Gene: 18554
  • Gene Overview
    MyGene.info: PCSK7
Location & Maps
more
  • Sequence Map
    Chr9:45906497-45929726 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23230 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 25.32 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PCSK7, proprotein convertase subtilisin/kexin type 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PCSK7, proprotein convertase subtilisin/kexin type 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LPC, PC7, PC8, SPC7
  • Links
    NCBI Gene ID: 9159
    neXtProt AC: NX_Q16549
    UniProt: Q16549

  • Chr Location
    11q23.3; chr11:117205071-117232525 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Mice homozygous for a knock-out allele exhibit normal response to LPS.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035382 Ensembl Gene Model | MGI Sequence Detail 23230 C57BL/6J ±  kb
transcript ENSMUST00000216672 Ensembl | MGI Sequence Detail 3599 Not Applicable  
polypeptide ENSMUSP00000150393 Ensembl | MGI Sequence Detail 770 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    116 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 11
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35891, MGI:2142967
References
more
  • Summaries
    All 32
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:34068 Constam DB, et al., SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis. J Cell Biol. 1996 Jul;134(1):181-91
  • Latest
    J:241679 Anyetei-Anum EN, et al., Prohormone convertase 7 is necessary for the normal processing of cholecystokinin in mouse brain. Biochem Biophys Res Commun. 2017 Jan 22;482(4):1190-1193

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory