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Ptprn2
Gene Detail
Symbol

Name
ID
Ptprn2
protein tyrosine phosphatase, receptor type, N polypeptide 2
MGI:107418
Synonyms
4930425H11Rik, IA-2beta, IA-2 beta, phogrin, PTP-NP
Feature Type
protein coding gene
Genetic Map
Chromosome 12
62.65 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr12:116485720-117276849 bp, + strand
From VEGA annotation of GRCm38

  791130 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2134  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PTPRN2
Protein SuperFamily: receptor-type tyrosine-protein phosphatase N-like protein
Gene Tree: Ptprn2

Human
homologs
PTPRN2, protein tyrosine phosphatase, receptor type, N polypeptide 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5799
neXtProt AC: NX_Q92932

Human Synonyms: IA-2beta, IAR, ICAAR, PTPRP, R-PTP-N2

Human Chr (Location): 7q36; chr7:157539056-158587796 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(4) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display impaired glucose tolerance but normal fasting and non-fasting blood glucose and insulin levels.
 
Human Diseases Modeled in Mice Using Ptprn2 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Ptprn2 interacts with 202 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process dephosphorylation, negative regulation of GTPase activity, ...
Component cytoplasm, cytoplasmic vesicle, ...
Function hydrolase activity, phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (61)    Tissues (28)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 35
Northern blot 26
cDNA source data(26)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN ptprn2    NEW 
Molecular
reagents
All nucleic(30) Genomic(1) cDNA(29)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000048735 (Evidence)
Ensembl Gene Model ENSMUSG00000056553 (Evidence)
Entrez Gene 19276 (Evidence)
UniGene 206054
DFCI TC1623554, TC1614624, TC1590066, TC1586934, TC1758868
DoTS DT.87048775, DT.101365946, DT.101317543, DT.97403928, DT.91331375
NIA Mouse Gene Index U014485
EC 3.1.3.48
Consensus CDS Project CCDS36576.1
International Mouse Phenotyping Consortium Status Ptprn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048735 VEGA Gene Model | MGI Sequence Detail 791130 C57BL/6J ±  kb
transcript OTTMUST00000124742 VEGA | MGI Sequence Detail 3201 Not Applicable 
polypeptide OTTMUSP00000067813 VEGA | MGI Sequence Detail 1001 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(5) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(8734 from dbSNP Build 137)    SNPs within 2kb including multiple locations(8736)
Protein-related
information
ResourceIDDescription
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR021613 Protein-tyrosine phosphatase receptor IA-2
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013475 receptor-type tyrosine-protein phosphatase N2
References
(Earliest) J:34182 Chiang MK, et al., PTP-NP, a new member of the receptor protein tyrosine phosphatase family, implicated in development of nervous system and pancreatic endocrine cells. Development. 1996 Jul;122(7):2239-50
(Latest) J:210300 Carmona GN, et al., The dense core vesicle protein IA-2, but not IA-2beta, is required for active avoidance learning. Neuroscience. 2014 Jun 6;269:35-42
All references(46)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-35887, MGI:1921110

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory