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Ptprn2 Gene Detail
Summary
  • Symbol
    Ptprn2
  • Name
    protein tyrosine phosphatase, receptor type, N polypeptide 2
  • Synonyms
    4930425H11Rik, IA-2beta, IA-2 beta, phogrin, PTP-NP
  • Feature Type
    protein coding gene
  • IDs
    MGI:107418
    NCBI Gene: 19276
  • Gene Overview
    MyGene.info: PTPRN2
Location & Maps
more
  • Sequence Map
    Chr12:116485720-117276849 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      791130 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 62.65 cM, cytoband F
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    PTPRN2, protein tyrosine phosphatase, receptor type N2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PTPRN2, protein tyrosine phosphatase, receptor type N2
    Orthology source: HomoloGene
  • Synonyms
    IA-2beta, IAR, ICAAR, PTPRP, R-PTP-N2
  • Links
    NCBI Gene ID: 5799
    neXtProt AC: NX_Q92932

  • Chr Location
    7q36; chr7:157539056-158587796 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Ptprn2 mouse models

Human Disease Mouse Models
       Diabetes Mellitus, Insulin-Dependent; IDDM   OMIM: 222100 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous null mice display impaired glucose tolerance but normal fasting and non-fasting blood glucose and insulin levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048735 VEGA Gene Model | MGI Sequence Detail 791130 C57BL/6J ±  kb
transcript OTTMUST00000124742 VEGA | MGI Sequence Detail 3201 Not Applicable  
polypeptide OTTMUSP00000067813 VEGA | MGI Sequence Detail 1001 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    8632 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000013475 receptor-type tyrosine-protein phosphatase N2
  • EC
  • InterPro Domains
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR029021 Protein-tyrosine phosphatase-like
    IPR021613 Protein-tyrosine phosphatase receptor IA-2 ectodomain
    IPR000242 PTP type protein phosphatase
    IPR029403 RESP18 domain
    IPR000387 Tyrosine specific protein phosphatases domain
Molecular
Reagents
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  • All nucleic 30
    Genomic 1
    cDNA 29

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35887, MGI:1921110
References
more
  • Summaries
    All 45
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 9
    Phenotypes 12
  • Earliest
    J:34182 Chiang MK, et al., PTP-NP, a new member of the receptor protein tyrosine phosphatase family, implicated in development of nervous system and pancreatic endocrine cells. Development. 1996 Jul;122(7):2239-50
  • Latest
    J:226444 Xu H, et al., The Ia-2beta intronic miRNA, miR-153, is a negative regulator of insulin and dopamine secretion through its effect on the Cacna1c gene in mice. Diabetologia. 2015 Oct;58(10):2298-306

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory