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Ptprn2
Gene Detail
 Symbol
Name
ID
Ptprn2
protein tyrosine phosphatase, receptor type, N polypeptide 2
MGI:107418
Synonyms 4930425H11Rik, IA-2beta, IA-2 beta, phogrin, PTP-NP
Feature Type protein coding gene
Genetic Map
Chromosome 12
62.65 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr12:116485720-117278167 bp, + strand
From NCBI annotation of GRCm38

  792448 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2134  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: receptor-type tyrosine-protein phosphatase N-like protein
Gene Tree: Ptprn2

Human
homologs
Human Homolog PTPRN2, protein tyrosine phosphatase, receptor type, N polypeptide 2
NCBI Gene ID 5799
neXtProt AC  NX_Q92932
Human Synonyms  IA-2beta, IAR, ICAAR, PTPRP, R-PTP-N2
Human Chr (Location)  7q36; chr7:157539056-158587796 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(1) Gene trapped(4)
 
Homozygous null mice display impaired glucose tolerance but normal fasting and non-fasting blood glucose and insulin levels.
 
Human Diseases Modeled Using Mouse Ptprn2 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process dephosphorylation, negative regulation of GTPase activity, ...
Component cytoplasm, cytoplasmic vesicle, ...
Function hydrolase activity, phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (61)    Tissues (29)    Images (24)
Theiler Stages: 13, 15, 17, 20, 21, 23, 28
Assay TypeResults
RNA in situ 35
Northern blot 26
cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(30) Genomic(1) cDNA(29)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000056553 (Evidence)
Entrez Gene19276 (Evidence)
UniGene206054
DFCITC1586934, TC1590066, TC1614624, TC1623554, TC1758868
DoTSDT.101317543, DT.101365946, DT.87048775, DT.91331375, DT.97403928
NIA Mouse Gene IndexU014485
EC3.1.3.48
Consensus CDS ProjectCCDS36576.1
International Mouse Knockout Project StatusPtprn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19276 NCBI Gene Model | MGI Sequence Detail 792448 C57BL/6J ±  kb
transcript NM_011215 RefSeq | MGI Sequence Detail 4688 C57BL/6 
polypeptide P80560 UniProt | EBI | MGI Sequence Detail 1001 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(3) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(8738 from dbSNP Build 137)    SNPs within 2kb including multiple locations(8740)
Protein-related
information
ResourceIDDescription
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR021613 Protein-tyrosine phosphatase receptor IA-2
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013475 receptor-type tyrosine-protein phosphatase N2
Graphical View of Protein Domain Structure
References (Earliest) J:34182 Chiang MK, et al., PTP-NP, a new member of the receptor protein tyrosine phosphatase family, implicated in development of nervous system and pancreatic endocrine cells. Development. 1996 Jul;122(7):2239-50
(Latest) J:198964 Mandemakers W, et al., Co-regulation of intragenic microRNA miR-153 and its host gene Ia-2 beta: identification of miR-153 target genes with functions related to IA-2beta in pancreas and brain. Diabetologia. 2013 Jul;56(7):1547-56
All references(47)
Other
accession IDs
MGD-MRK-35887, MGI:1921110

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory