Ptprn2
Gene Detail

Symbol Name ID

Ptprn2 protein tyrosine phosphatase, receptor type, N polypeptide 2 MGI:107418

Synonyms

4930425H11Rik, IA-2beta, IA-2 beta, phogrin, PTP-NP

Feature Type

protein coding gene

Genetic Map

Chromosome 12

62.65 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr12:116485720-117278167 bp, + strand From NCBI annotation of GRCm38   792448 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2134  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: receptor-type tyrosine-protein phosphatase N-like protein
Gene Tree: Ptprn2

Human homologs

Human Homolog		PTPRN2, protein tyrosine phosphatase, receptor type, N polypeptide 2
NCBI Gene ID		5799
neXtProt AC		NX_Q92932
Human Synonyms		IA-2beta, IAR, ICAAR, PTPRP, R-PTP-N2
Human Chr (Location)		7q36; chr7:157331750-158380482 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(1) Gene trapped(4)
 

Homozygous null mice display impaired glucose tolerance but normal fasting and non-fasting blood glucose and insulin levels.

 
Human Diseases Modeled Using Mouse Ptprn2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	dephosphorylation, negative regulation of GTPase activity, ...
Component	cytoplasm, cytoplasmic vesicle, ...
Function	hydrolase activity, phosphatase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (61)    Tissues (29)    Images (24)
Theiler Stages: 13, 15, 17, 20, 21, 23, 28

Assay Type	Results
RNA in situ	35
Northern blot	26

cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(30) Genomic(1) cDNA(29)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000056553 (Evidence)
Entrez Gene	19276 (Evidence)
UniGene	206054
DFCI	TC1586934, TC1590066, TC1614624, TC1623554, TC1758868
DoTS	DT.101317543, DT.101365946, DT.87048775, DT.91331375, DT.97403928
NIA Mouse Gene Index	U014485
EC	3.1.3.48
Consensus CDS Project	CCDS36576.1
International Mouse Knockout Project Status	Ptprn2

Sequences

Length	Strain/Species
genomic	19276	NCBI Gene Model | MGI Sequence Detail	792448	C57BL/6J
transcript	NM_011215	RefSeq | MGI Sequence Detail	4688	C57BL/6
polypeptide	P80560	UniProt | EBI | MGI Sequence Detail	1001	Not Applicable

All sequences(30) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(5049 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000387	Protein-tyrosine/Dual specificity phosphatase
InterPro	IPR016130	Protein-tyrosine phosphatase, active site
InterPro	IPR021613	Protein-tyrosine phosphatase receptor IA-2
InterPro	IPR000242	Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology	PR:000013475	receptor-type tyrosine-protein phosphatase N2

Graphical View of Protein Domain Structure

References

(Earliest) J:34182 Chiang MK, et al., PTP-NP, a new member of the receptor protein tyrosine phosphatase family, implicated in development of nervous system and pancreatic endocrine cells. Development. 1996 Jul;122(7):2239-50
(Latest) J:189520 Punia S, et al., Disruption of gene expression rhythms in mice lacking secretory vesicle proteins IA-2 and IA-2beta. Am J Physiol Endocrinol Metab. 2012 Sep 15;303(6):E762-76
All references(43)

Other accession IDs

MGD-MRK-35887, MGI:1921110