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Zbtb17 Gene Detail
Summary
  • Symbol
    Zbtb17
  • Name
    zinc finger and BTB domain containing 17
  • Synonyms
    Miz1, mZ13, Zfp100
  • Feature Type
    protein coding gene
  • IDs
    MGI:107410
    NCBI Gene: 22642
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:141171984-141195248 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 74.17 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    604 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107410
 protein coding gene Chr4:141171965-141195248 (+)
129S1/SvImJ ENSMUSG00200043778
 protein coding gene Chr4:134594452-134616690 (+)
A/J ENSMUSG00195033652
 protein coding gene Chr4:135937920-135960492 (+)
AKR/J ENSMUSG00220047223
 protein coding gene Chr4:134938715-134961290 (+)
BALB/cJ ENSMUSG00180041691
 protein coding gene Chr4:133578963-133601537 (+)
C3H/HeJ ENSMUSG00175038953
 protein coding gene Chr4:134605543-134628116 (+)
C57BL/6NJ ENSMUSG00215047725
 protein coding gene Chr4:136123473-136146044 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026744
 protein coding gene Chr4:131128898-131152061 (+)
CAST/EiJ ENSTCUG00005012948
 protein coding gene Chr4:135560787-135583312 (+)
CBA/J ENSMUSG00210028530
 protein coding gene Chr4:134229471-134252049 (+)
DBA/2J ENSMUSG00185047216
 protein coding gene Chr4:135740977-135763278 (+)
FVB/NJ ENSMUSG00205022980
 protein coding gene Chr4:133994048-134016375 (+)
JF1/MsJ ENSUMUG00000029114
 protein coding gene Chr4:136426812-136449355 (+)
LP/J ENSMUSG00230038718
 protein coding gene Chr4:139532958-139555189 (+)
NOD/ShiLtJ ENSMUSG00190030446
 protein coding gene Chr4:133989575-134011897 (+)
NZO/HlLtJ ENSMUSG00225009821
 protein coding gene Chr4:145479310-145501637 (+)
PWK/PhJ ENSLUMG00010040326
 protein coding gene Chr4:133426404-133448703 (+)
SPRET/EiJ ENSMSPG00010026814
 protein coding gene Chr4:135470294-135492617 (+)
WSB/EiJ ENSIUOG00005044959
 protein coding gene Chr4:133874250-133896567 (+)



Homology
more
  • Human Ortholog
    ZBTB17, zinc finger and BTB domain containing 17
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZBTB17, zinc finger and BTB domain containing 17
  • Synonyms
    MIZ-1, pHZ-67, ZNF151, ZNF60
  • Links
    NCBI Gene ID: 7709
    UniProt: Q13105

  • Chr Location
    1p36.13; chr1:15940403-15976132 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryonic development of homozygous null mice is severely impaired and death occurs prior to E8.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    655
  • Tissues
    58
  • cDNA Data
    11
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22642 NCBI Gene Model | MGI Sequence Detail 23265 C57BL/6J ±  kb
    transcript NM_009541 RefSeq | MGI Sequence Detail 3415 C57BL/6  
    polypeptide Q60821 UniProt | EBI | MGI Sequence Detail 794 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 1
      cDNA 11
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35879, MGI:2140165
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 9
      Gene Ontology 10
      Phenotypes 30
    • Earliest
      J:29058 Schulz TC, et al., An unusual arrangement of 13 zinc fingers in the vertebrate gene Z13. Biochem J. 1995 Oct 1;311(Pt 1):219-24
    • Latest
      J:383122 Ross J, et al., MIZ-1 controls transcriptional programs required for BCR signaling, actin dynamics, and naive B cell survival. Front Immunol. 2026;17:1758550
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory