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Zbtb17 Gene Detail
Summary
  • Symbol
    Zbtb17
  • Name
    zinc finger and BTB domain containing 17
  • Synonyms
    Miz1, mZ13, Zfp100
  • Feature Type
    protein coding gene
  • IDs
    MGI:107410
    NCBI Gene: 22642
  • Gene Overview
    MyGene.info: ZBTB17
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:141444654-141467930 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 74.17 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    353 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107410
protein coding gene Chr4:141444654-141467937 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029048
protein coding gene Chr4:144504278-144528863 (+)
A/J MGP_AJ_G0029008
protein coding gene Chr4:138213670-138236641 (+)
AKR/J MGP_AKRJ_G0028960
protein coding gene Chr4:142202735-142240485 (+)
BALB/cJ MGP_BALBcJ_G0029032
protein coding gene Chr4:138906697-138930006 (+)
C3H/HeJ MGP_C3HHeJ_G0028746
protein coding gene Chr4:142581218-142606006 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029473
protein coding gene Chr4:149531078-149554559 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026744
protein coding gene Chr4:131128898-131152061 (+)
CAST/EiJ MGP_CASTEiJ_G0028178
protein coding gene Chr4:140848720-140873063 (+)
CBA/J MGP_CBAJ_G0028710
protein coding gene Chr4:153894034-153922981 (+)
DBA/2J MGP_DBA2J_G0028860
protein coding gene Chr4:138615812-138638789 (+)
FVB/NJ MGP_FVBNJ_G0028827
protein coding gene Chr4:137732865-137756729 (+)
LP/J MGP_LPJ_G0028959
protein coding gene Chr4:144528083-144552745 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028853
protein coding gene Chr4:157705049-157728048 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029511
protein coding gene Chr4:142740983-142764005 (+)
PWK/PhJ MGP_PWKPhJ_G0027899
protein coding gene Chr4:135502574-135525880 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027723
protein coding gene Chr4:138551633-138574629 (+)
WSB/EiJ MGP_WSBEiJ_G0028256
protein coding gene Chr4:143019115-143042117 (+)



Homology
more
  • Human Ortholog
    ZBTB17, zinc finger and BTB domain containing 17
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZBTB17, zinc finger and BTB domain containing 17
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MIZ-1, pHZ-67, ZNF151, ZNF60
  • Links
    NCBI Gene ID: 7709
    neXtProt AC: NX_Q13105
    UniProt: Q13105

  • Chr Location
    1p36.13; chr1:15941869-15976132 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2575
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZBTB17
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryonic development of homozygous null mice is severely impaired and death occurs prior to E8.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006215 Ensembl Gene Model | MGI Sequence Detail 23277 C57BL/6J ±  kb
    transcript ENSMUST00000006377 Ensembl | MGI Sequence Detail 2722 Not Applicable  
    polypeptide ENSMUSP00000006377 Ensembl | MGI Sequence Detail 794 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 1
      cDNA 11
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35879, MGI:2140165
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 24
    • Earliest
      J:29058 Schulz TC, et al., An unusual arrangement of 13 zinc fingers in the vertebrate gene Z13. Biochem J. 1995 Oct 1;311(Pt 1):219-24
    • Latest
      J:257049 Fuhrmann D, et al., Miz1 Controls Schwann Cell Proliferation via H3K36(me2) Demethylase Kdm8 to Prevent Peripheral Nerve Demyelination. J Neurosci. 2018 Jan 24;38(4):858-877

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory