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Il17ra
Gene Detail
Symbol

Name
ID
Il17ra
interleukin 17 receptor A
MGI:107399
Synonyms
Il17r, VDw217
Feature Type
protein coding gene
Genetic Map
Chromosome 6
56.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr6:120463197-120483727 bp, + strand
From Ensembl annotation of GRCm38

  20531 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7378  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

HCOP human homology predictions: IL17RA
Gene Tree: Il17ra

Human
homologs
IL17RA, interleukin 17 receptor A
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23765
neXtProt AC: NX_Q96F46

Human Synonyms: CANDF5, CD217, CDw217, hIL-17R, IL17R, IL-17RA

Human Chr (Location): 22q11.1; chr22:17084959-17115694 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IL17RA

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit delayed neutrophil recruitment and enhanced susceptibility to intranasal infection by Klibsiella pneumoniae. Mice homozygous for a different knock-out allele exhibit delayed and milder IMQ-induced psoriasis.
 
Interactions
Il17ra interacts with 194 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (5)    Tissues (1)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
cDNA source data(56)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(59) cDNA(57) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000002897 (Evidence)
Entrez Gene 16172 (Evidence)
UniGene 4481
DFCI TC1581495, TC1599393, TC1583055
DoTS DT.529054, DT.101335937
NIA Mouse Gene Index U007342
Consensus CDS Project CCDS20482.1
International Mouse Phenotyping Consortium Status Il17ra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002897 Ensembl Gene Model | MGI Sequence Detail 20531 C57BL/6J ±  kb
transcript ENSMUST00000002976 Ensembl | MGI Sequence Detail 3970 Not Applicable 
polypeptide ENSMUSP00000002976 Ensembl | MGI Sequence Detail 864 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(6) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013568 SEFIR
Protein Ontology PR:000001375 interleukin-17 receptor A
References
(Earliest) J:30252 Yao Z, et al., Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity. 1995 Dec;3(6):811-21
(Latest) J:222042 Varelias A, et al., Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation. Blood. 2015 Apr 9;125(15):2435-44
All references(152)
Other
accession IDs
MGD-MRK-35866, MGI:2141691

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory