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Il17ra Gene Detail
Summary
  • Symbol
    Il17ra
  • Name
    interleukin 17 receptor A
  • Synonyms
    Il17r, VDw217
  • Feature Type
    protein coding gene
  • IDs
    MGI:107399
    NCBI Gene: 16172
  • Gene Overview
    MyGene.info: IL17RA
Location & Maps
more
  • Sequence Map
    Chr6:120463247-120487559 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24313 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IL17RA, interleukin 17 receptor A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IL17RA, interleukin 17 receptor A
    Orthology source: HomoloGene
  • Synonyms
    CANDF5, CD217, CDw217, hIL-17R, IL17R, IL-17RA
  • Links
    NCBI Gene ID: 23765
    neXtProt AC: NX_Q96F46

  • Chr Location
    22q11.1; chr22:17084959-17115694 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human IL17RA associations

Human Disease Mouse Models
       Candidiasis, Familial, 5; CANDF5   OMIM: 613953
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    115 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit delayed neutrophil recruitment and enhanced susceptibility to intranasal infection by Klibsiella pneumoniae. Mice homozygous for a different knock-out allele exhibit delayed and milder IMQ-induced psoriasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056821 VEGA Gene Model | MGI Sequence Detail 24313 C57BL/6J ±  kb
transcript OTTMUST00000140173 VEGA | MGI Sequence Detail 7752 Not Applicable  
polypeptide OTTMUSP00000073506 VEGA | MGI Sequence Detail 864 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    76 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001375 interleukin-17 receptor A
  • InterPro Domains
    IPR032356 Interleukin-17 receptor, fibronectin-III-like domain 1
    IPR013568 SEFIR domain
Molecular
Reagents
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  • All nucleic 59
    cDNA 57
    Other 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-35866, MGI:2141691
References
more
  • Summaries
    All 156
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 115
  • Earliest
    J:30252 Yao Z, et al., Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity. 1995 Dec;3(6):811-21
  • Latest
    J:229446 Choi GB, et al., The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring. Science. 2016 Feb 26;351(6276):933-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory