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Il17ra Gene Detail
Summary
  • Symbol
    Il17ra
  • Name
    interleukin 17 receptor A
  • Synonyms
    Il17r, VDw217
  • Feature Type
    protein coding gene
  • IDs
    MGI:107399
    NCBI Gene: 16172
  • Gene Overview
    MyGene.info: IL17RA
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:120463181-120483731 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 56.95 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107399
protein coding gene Chr6:120463181-120487559 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031204
protein coding gene Chr6:123355585-123380289 (+)
A/J MGP_AJ_G0031173
protein coding gene Chr6:118612385-118638066 (+)
AKR/J MGP_AKRJ_G0031104
protein coding gene Chr6:121812098-121840407 (+)
BALB/cJ MGP_BALBcJ_G0031184
protein coding gene Chr6:118376555-118401058 (+)
C3H/HeJ MGP_C3HHeJ_G0030525
protein coding gene Chr6:62473153-62497978 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031642
protein coding gene Chr6:126505235-126529320 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028802
protein coding gene Chr6:115514678-115540100 (+)
CAST/EiJ MGP_CASTEiJ_G0030291
protein coding gene Chr6:122250536-122280040 (+)
CBA/J MGP_CBAJ_G0030867
protein coding gene Chr6:131534390-131559753 (+)
DBA/2J MGP_DBA2J_G0031023
protein coding gene Chr6:117498011-117522763 (+)
FVB/NJ MGP_FVBNJ_G0030975
protein coding gene Chr6:116627096-116652156 (+)
LP/J MGP_LPJ_G0031102
protein coding gene Chr6:123344701-123370066 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031009
protein coding gene Chr6:135518319-135543688 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031671
protein coding gene Chr6:121835201-121860111 (+)
PWK/PhJ MGP_PWKPhJ_G0030006
protein coding gene Chr6:116536953-116561370 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029835
protein coding gene Chr6:120569224-120596078 (+)
WSB/EiJ MGP_WSBEiJ_G0030374
protein coding gene Chr6:122124406-122153739 (+)



Homology
more
  • Human Ortholog
    IL17RA, interleukin 17 receptor A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IL17RA, interleukin 17 receptor A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CANDF5, CD217, CDw217, hIL-17R, IL17R, IL-17RA, IMD51
  • Links
    NCBI Gene ID: 23765
    neXtProt AC: NX_Q96F46
    UniProt: Q96F46

  • Chr Location
    22q11.1; chr22:17084959-17115694 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human IL17RA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    133 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit delayed neutrophil recruitment and enhanced susceptibility to intranasal infection by Klibsiella pneumoniae. Mice homozygous for a different knock-out allele exhibit delayed and milder IMQ-induced psoriasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16172 NCBI Gene Model | MGI Sequence Detail 20551 C57BL/6J ±  kb
    transcript NM_008359 RefSeq | MGI Sequence Detail 3970 C57BL/6  
    polypeptide Q60943 UniProt | EBI | MGI Sequence Detail 864 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 58

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35866, MGI:2141691
    References
    more
    • Summaries
      All 185
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 133
    • Earliest
      J:30252 Yao Z, et al., Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity. 1995 Dec;3(6):811-21
    • Latest
      J:265749 Chen G, et al., Sca-1(+) cardiac fibroblasts promote development of heart failure. Eur J Immunol. 2018 Sep;48(9):1522-1538

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory