Homozygotes for a targeted mutation exhibit decreased urine osmolality associated with reduced water permeability in inner medullary collecting ducts, increased survival rates and reduced brain edema after acute water intoxication and ischemic stroke, as well as significant hearing impairment.
|Ensembl Gene Model||ENSMUSG00000024411 (Evidence)|
|Entrez Gene||11829, 102632175|
|DFCI||TC1599303, TC1580446, TC1647087, TC1668635|
|DoTS||DT.101375194, DT.60100874, DT.94259625, DT.87049496, DT.94220478, DT.91439275, DT.91391996|
|NIA Mouse Gene Index||U038230|
|Consensus CDS Project||CCDS29073.1|
|International Mouse Knockout Project Status||Aqp4|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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