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Aqp4
Gene Detail
Symbol

Name
ID
Aqp4
aquaporin 4
MGI:107387
Synonyms
aquaporin-4
Feature Type
protein coding gene
Genetic Map
Chromosome 18
8.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:15389394-15403684 bp, - strand
From Ensembl annotation of GRCm38

  14291 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: aquaporin
Gene Tree: Aqp4
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted mutation exhibit decreased urine osmolality associated with reduced water permeability in inner medullary collecting ducts, increased survival rates and reduced brain edema after acute water intoxication and ischemic stroke, as well as significant hearing impairment.
 
Human Diseases Modeled Using Mouse Aqp4 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Aqp4 interacts with 365 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process carbohydrate transmembrane transport, cellular response to stress, ...
Component basolateral plasma membrane, cell, ...
Function glycerol channel activity, transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (239)    Tissues (123)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 153
Western blot 14
RT-PCR 72
cDNA source data(60)
External Resources: Allen Institute   Expression Atlas
Molecular
reagents
All nucleic(67) Genomic(1) cDNA(62) Primer pair(4)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000024411 (Evidence)
Entrez Gene102632175, 11829
UniGene250786
DFCITC1580446, TC1668635, TC1647087, TC1599303
DoTSDT.101375194, DT.60100874, DT.91391996, DT.87049496, DT.91439275, DT.94259625, DT.94220478
NIA Mouse Gene IndexU038230
Consensus CDS ProjectCCDS29073.1
International Mouse Knockout Project StatusAqp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024411 Ensembl Gene Model | MGI Sequence Detail 14291 C57BL/6J ±  kb
transcript ENSMUST00000079081 Ensembl | MGI Sequence Detail 5082 Not Applicable 
polypeptide ENSMUSP00000078088 Ensembl | MGI Sequence Detail 323 Not Applicable 

For the selected sequences
All sequences(32) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(81 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023271 Aquaporin-like
InterPro IPR000425 Major intrinsic protein
InterPro IPR022357 Major intrinsic protein, conserved site
Protein Ontology PR:000004184 aquaporin-4
References
(Earliest) J:32891 Ma T, et al., Gene structure, cDNA cloning, and expression of a mouse mercurial-insensitive water channel. Genomics. 1996 May 1;33(3):382-8
(Latest) J:214848 Chu H, et al., Erythropoietin protects against hemorrhagic blood-brain barrier disruption through the effects of aquaporin-4. Lab Invest. 2014 Sep;94(9):1042-53
All references(154)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-35854

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory