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Dnajc3
Gene Detail
Symbol

Name
ID
Dnajc3
DnaJ (Hsp40) homolog, subfamily C, member 3
MGI:107373
Synonyms
Dnajc3, Dnajc3a, Dnajc3b, mp58, p58IPK, Prkri
Feature Type
protein coding gene
Genetic Map
Chromosome 14
62.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:118937932-118981702 bp, + strand
From NCBI annotation of GRCm38

  43771 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2486  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dnajc3

Human
homologs
Human Homolog DNAJC3, DnaJ (Hsp40) homolog, subfamily C, member 3
NCBI Gene ID 5611
neXtProt AC  NX_Q13217
Human Synonyms  ERdj6, HP58, P58, P58IPK, PRKRI
Human Chr (Location)  13q32.1; chr13:95677139-95794989 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(11) Targeted(3)
Incidental mutations (data from APF )
 
Homozygous null mice are smaller in size, have a lower percentage of body fat and develop a gradual onset of glucosuria and hyperglycemia associated with increasing apoptosis of pancreatic islet cells.
 
Interactions
Dnajc3 interacts with 328 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process endoplasmic reticulum unfolded protein response, negative regulation of protein kinase activity, ...
Component cytoplasm, cytosol, ...
Function chaperone binding, misfolded protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (48)    Tissues (46)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 48
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(15) Primer pair(2)
Microarray probesets(9)
Other database
links
Ensembl Gene ModelENSMUSG00000022136 (Evidence)
Entrez Gene100037258 (Evidence)
DFCITC1575207, TC1606164, TC1611635, TC1653809
DoTSDT.102557320
NIA Mouse Gene IndexU043422, U354102
PDB3IEG
Consensus CDS ProjectCCDS37012.1
International Mouse Knockout Project StatusDnajc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 100037258 NCBI Gene Model | MGI Sequence Detail 43771 C57BL/6J ±  kb
transcript NM_008929 RefSeq | MGI Sequence Detail 5190 C57BL/6 
polypeptide Q91YW3 UniProt | EBI | MGI Sequence Detail 504 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(369 from dbSNP Build 137)    SNPs within 2kb including multiple locations(371)
Protein-related
information
ResourceIDDescription
InterPro IPR001623 DnaJ domain
InterPro IPR026901 DnaJ homologue subfamily C member 3
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR001440 Tetratricopeptide TPR-1
Protein Ontology PR:000006587 DnaJ homolog subfamily C member 3
Graphical View of Protein Domain Structure
References
(Earliest) J:33042 Korth MJ, et al., Cloning, expression, and cellular localization of the oncogenic 58-kDa inhibitor of the RNA-activated human and mouse protein kinase. Gene. 1996 May 8;170(2):181-8
(Latest) J:211890 Gomez JA, et al., Synthetic embryonic lethality upon deletion of the ER cochaperone p58(IPK) and the ER stress sensor ATF6alpha. Biochem Biophys Res Commun. 2014 Jan 3;443(1):115-9
All references(46)
Other
accession IDs
MGD-MRK-35840, MGI:2145552, MGI:2145768, MGI:3696572

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory