Dnajc3 MGI Mouse Gene Detail - MGI:107373 - DnaJ heat shock protein family (Hsp40) member C3

Symbol

Dnajc3
Name

DnaJ heat shock protein family (Hsp40) member C3
Synonyms

Dnajc3, Dnajc3a, Dnajc3b, mp58, p58IPK, Prkri

Feature Type

protein coding gene
IDs

MGI:107373
NCBI Gene: 100037258
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr14:119175388-119219109 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 62.60 cM
Mapping Data

3 experiments

SNPs within 2kb

1169 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107373	protein coding gene	Chr14:119175371-119219114 (+)
129S1/SvImJ	ENSMUSG00200024377	protein coding gene	Chr14:108051253-108092967 (+)
A/J	ENSMUSG00195030042	protein coding gene	Chr14:107798007-107841658 (+)
AKR/J	ENSMUSG00220007602	protein coding gene	Chr14:107591337-107634977 (+)
BALB/cJ	ENSMUSG00180026449	protein coding gene	Chr14:107290013-107333657 (+)
C3H/HeJ	ENSMUSG00175005705	protein coding gene	Chr14:109231036-109274678 (+)
C57BL/6NJ	ENSMUSG00215020306	protein coding gene	Chr14:107441343-107485052 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019597	protein coding gene	Chr14:108141796-108179819 (+)
CAST/EiJ	ENSTCUG00005007117	protein coding gene	Chr14:108872839-108914756 (+)
CBA/J	ENSMUSG00210026751	protein coding gene	Chr14:108193964-108237607 (+)
DBA/2J	ENSMUSG00185013546	protein coding gene	Chr14:113350430-113394072 (+)
FVB/NJ	ENSMUSG00205007575	protein coding gene	Chr14:106884843-106928477 (+)
JF1/MsJ	ENSUMUG00000020465	protein coding gene	Chr14:124381689-124423486 (+)
LP/J	ENSMUSG00230012289	protein coding gene	Chr14:125340060-125383773 (+)
NOD/ShiLtJ	ENSMUSG00190020689	protein coding gene	Chr14:107999544-108043193 (+)
NZO/HlLtJ	ENSMUSG00225029010	protein coding gene	Chr14:115361313-115405039 (+)
PWK/PhJ	ENSLUMG00010028054	protein coding gene	Chr14:107280324-107322052 (+)
SPRET/EiJ	ENSMSPG00010012228	protein coding gene	Chr14:111509846-111548538 (+)
WSB/EiJ	ENSIUOG00005030420	protein coding gene	Chr14:107223328-107266917 (+)

Human Ortholog

DNAJC3, DnaJ heat shock protein family (Hsp40) member C3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAJC3, DnaJ heat shock protein family (Hsp40) member C3
Synonyms

ACPHD, ERdj6, HP58, P58, p58(IPK), P58IPK, PRKRI
Links

HGNC:9439

NCBI Gene ID: 5611

UniProt: Q13217
Chr Location

13q32.1; chr13:95677114-95794988 (+) GRCh38

MGI Vertebrate Homology

Dnajc3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DNAJC3
Gene Tree

Dnajc3

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Phenotype Summary

16 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (ENU)

1
Chemically induced (other)

1
Gene trapped

11
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Dnajc3
Incidental Mutations

APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are smaller in size, have a lower percentage of body fat and develop a gradual onset of glucosuria and hyperglycemia associated with increasing apoptosis of pancreatic islet cells.

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All GO Annotations

29
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

650
Tissues

50
cDNA Data

14
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnajc3

ZFIN dnajc3a, dnajc3b

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All Sequences

48
RefSeq

2
UniProt

3
CCDS

CCDS37012.1

Ensembl

ENSMUSG00000022136 (Evidence)
NCBI Gene

100037258

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022136	Ensembl Gene Model \| MGI Sequence Detail	43722	C57BL/6J	± kb
transcript	ENSMUST00000022734	Ensembl \| MGI Sequence Detail	5141	Not Applicable
polypeptide	ENSMUSP00000022734	Ensembl \| MGI Sequence Detail	504	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006587 DnaJ homolog subfamily C member 3

(term hierarchy)
PDB

3IEG
InterPro Domains

IPR036869 Chaperone J-domain superfamily

IPR001623 DnaJ domain

IPR051727 DnaJ Homolog Subfamily C Member 3 Co-Chaperones

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat

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All nucleic 19

Genomic 1

cDNA 15

Primer pair 3

Microarray probesets 9

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MGD-MRK-35840, MGI:2145552, MGI:2145768, MGI:3696572

Summaries

All 68

Developmental Gene Expression 8

Gene Ontology 9

Phenotypes 24
Earliest

J:33042 Korth MJ, et al., Cloning, expression, and cellular localization of the oncogenic 58-kDa inhibitor of the RNA-activated human and mouse protein kinase. Gene. 1996 May 8;170(2):181-8
Latest

J:376296 Feng W, et al., ASNA1 is essential for cardiac development and function by regulating tail-anchored protein stability and vesicular transport in cardiomyocytes. PLoS Genet. 2025 Dec;21(12):e1011964

TSS for Dnajc3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr127175	Chr14:119175337-119175404 (+)	-17 bp
Tssr127177	Chr14:119190564-119190578 (+)	15,183 bp
Tssr127178	Chr14:119190626-119190641 (+)	15,246 bp
Tssr127179	Chr14:119190840-119190854 (+)	15,459 bp
Tssr127180	Chr14:119190897-119190917 (+)	15,519 bp
Tssr127181	Chr14:119190925-119190948 (+)	15,549 bp
Tssr127182	Chr14:119209309-119209312 (+)	33,923 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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