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Dnajc3 Gene Detail
Summary
  • Symbol
    Dnajc3
  • Name
    DnaJ heat shock protein family (Hsp40) member C3
  • Synonyms
    Dnajc3, Dnajc3a, Dnajc3b, mp58, p58IPK, Prkri
  • Feature Type
    protein coding gene
  • IDs
    MGI:107373
    NCBI Gene: 100037258
  • Gene Overview
    MyGene.info: DNAJC3
Location & Maps
more
  • Sequence Map
    Chr14:118937932-118981702 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      43771 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DNAJC3, DnaJ heat shock protein family (Hsp40) member C3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DNAJC3, DnaJ heat shock protein family (Hsp40) member C3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACPHD, ERdj6, HP58, P58, P58IPK, PRKRI
  • Links
    NCBI Gene ID: 5611
    neXtProt AC: NX_Q13217

  • Chr Location
    13q32.1; chr13:95677139-95794989 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2486
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DNAJC3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human DNAJC3 associations

Human Disease Mouse Models
       Ataxia, Combined Cerebellar and Peripheral, with Hearing Loss and Diabetes Mellitus; ACPHD   OMIM: 616192
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    1
  • Gene trapped
    11
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Dnajc3
  • Incidental Mutations
    APF
Homozygous null mice are smaller in size, have a lower percentage of body fat and develop a gradual onset of glucosuria and hyperglycemia associated with increasing apoptosis of pancreatic islet cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 100037258 NCBI Gene Model | MGI Sequence Detail 43771 C57BL/6J ±  kb
transcript NM_008929 RefSeq | MGI Sequence Detail 5190 C57BL/6  
polypeptide Q91YW3 UniProt | EBI | MGI Sequence Detail 504 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    360 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 17
    cDNA 15
    Primer pair 2

    Microarray probesets 9
Other
Accession IDs
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MGD-MRK-35840, MGI:2145552, MGI:2145768, MGI:3696572
References
more
  • Summaries
    All 43
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:33042 Korth MJ, et al., Cloning, expression, and cellular localization of the oncogenic 58-kDa inhibitor of the RNA-activated human and mouse protein kinase. Gene. 1996 May 8;170(2):181-8
  • Latest
    J:218404 Roobol A, et al., p58IPK is an inhibitor of the eIF2alpha kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity. Biochem J. 2015 Jan 15;465(2):213-25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory