Rtkn MGI Mouse Gene Detail - MGI:107371

Symbol

Rtkn
Name

rhotekin

Feature Type

protein coding gene
IDs

MGI:107371
NCBI Gene: 20166
Alliance

genome feature page
Transcription Start Sites

13 TSS

Sequence Map

Chr6:83112485-83129560 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 35.94 cM
Mapping Data

4 experiments

SNPs within 2kb

398 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107371	protein coding gene	Chr6:83112444-83129560 (+)
129S1/SvImJ	ENSMUSG00200011340	protein coding gene	Chr6:80081760-80098497 (+)
A/J	ENSMUSG00195011512	protein coding gene	Chr6:79759237-79775940 (+)
AKR/J	ENSMUSG00220001888	protein coding gene	Chr6:78702652-78719351 (+)
BALB/cJ	ENSMUSG00180009035	protein coding gene	Chr6:80135237-80151937 (+)
C3H/HeJ	ENSMUSG00175032496	protein coding gene	Chr6:97258368-97275134 (-)
C57BL/6NJ	ENSMUSG00215010616	protein coding gene	Chr6:80132387-80149153 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028548	protein coding gene	Chr6:79285976-79303401 (+)
CAST/EiJ	ENSTCUG00005007912	protein coding gene	Chr6:80145109-80161968 (+)
CBA/J	ENSMUSG00210010517	protein coding gene	Chr6:79950756-79967522 (+)
DBA/2J	ENSMUSG00185000904	protein coding gene	Chr6:80497816-80514584 (+)
FVB/NJ	ENSMUSG00205017689	protein coding gene	Chr6:79176928-79193625 (+)
JF1/MsJ	ENSUMUG00000017106	protein coding gene	Chr6:79550778-79567633 (+)
LP/J	ENSMUSG00230049872	protein coding gene	Chr6:81639012-81655750 (+)
NOD/ShiLtJ	ENSMUSG00190001180	protein coding gene	Chr6:79580054-79596752 (+)
NZO/HlLtJ	ENSMUSG00225017417	protein coding gene	Chr6:83547356-83564207 (+)
PWK/PhJ	ENSLUMG00010005975	protein coding gene	Chr6:78901657-78918696 (+)
SPRET/EiJ	ENSMSPG00010033797	protein coding gene	Chr6:81055698-81073203 (+)
WSB/EiJ	ENSIUOG00005017919	protein coding gene	Chr6:80517790-80534499 (+)

Human Ortholog

RTKN, rhotekin

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RTKN, rhotekin
Synonyms

RTKN-1
Links

HGNC:10466

NCBI Gene ID: 6242

UniProt: Q9BST9
Chr Location

2p13.1; chr2:74425835-74442422 (-) GRCh38

MGI Vertebrate Homology

Rtkn stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RTKN
Gene Tree

Rtkn

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

5
Gene trapped

1
Spontaneous

1
Targeted

1
Genomic Mutations

2 involving Rtkn
Incidental Mutations

APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

22
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

643
Tissues

45
cDNA Data

93
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rtkn

ZFIN rtknb

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All Sequences

92
RefSeq

36
UniProt

5
CCDS

CCDS20274.1, CCDS51817.1

Ensembl

ENSMUSG00000034930 (Evidence)
NCBI Gene

20166

			Length	Strain/Species	Flank
genomic	20166	NCBI Gene Model \| MGI Sequence Detail	17076	C57BL/6J	± kb
transcript	NM_133641	RefSeq \| MGI Sequence Detail	3143	ZRU/MplStud
polypeptide	Q8C6B2	UniProt \| EBI \| MGI Sequence Detail	564	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000014342 rhotekin

(term hierarchy)
InterPro Domains

IPR012966 Anillin homology domain

IPR051364 Anillin/rhotekin

IPR011072 HR1 rho-binding domain

IPR001849 Pleckstrin homology domain
GlyGen

Q8C6B2 2 sites

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All nucleic 96

Genomic 2

cDNA 93

Primer pair 1

Microarray probesets 4

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MGD-MRK-35838

Summaries

All 54

Developmental Gene Expression 2

Gene Ontology 12

Phenotypes 13
Earliest

J:33389 Reid T, et al., Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain. J Biol Chem. 1996 Jun 7;271(23):13556-60
Latest

J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376

TSS for Rtkn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr57300	Chr6:83112809-83112855 (+)	347 bp
Tssr57301	Chr6:83112873-83112884 (+)	394 bp
Tssr57302	Chr6:83114021-83114040 (+)	1,546 bp
Tssr57303	Chr6:83114084-83114102 (+)	1,608 bp
Tssr57304	Chr6:83114115-83114133 (+)	1,639 bp
Tssr57305	Chr6:83114349-83114381 (+)	1,880 bp
Tssr57306	Chr6:83114785-83114818 (+)	2,317 bp
Tssr57307	Chr6:83114819-83114827 (+)	2,338 bp
Tssr57308	Chr6:83114831-83114847 (+)	2,354 bp
Tssr57309	Chr6:83114900-83114922 (+)	2,426 bp
Tssr57310	Chr6:83119368-83119410 (+)	6,904 bp
Tssr57311	Chr6:83122869-83122918 (+)	10,409 bp
Tssr57312	Chr6:83124454-83124496 (+)	11,990 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24