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Rtkn Gene Detail
Summary
  • Symbol
    Rtkn
  • Name
    rhotekin
  • Feature Type
    protein coding gene
  • IDs
    MGI:107371
    NCBI Gene: 20166
  • Gene Overview
    MyGene.info: RTKN
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:83135463-83152579 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    75 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107371
protein coding gene Chr6:83134428-83152579 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030923
protein coding gene Chr6:84142313-84159355 (+)
A/J MGP_AJ_G0030892
protein coding gene Chr6:80927880-80944878 (+)
AKR/J MGP_AKRJ_G0030820
protein coding gene Chr6:83262591-83279565 (+)
BALB/cJ MGP_BALBcJ_G0030902
protein coding gene Chr6:80948021-80965159 (+)
C3H/HeJ MGP_C3HHeJ_G0030808
protein coding gene Chr6:101106882-101124835 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031362
protein coding gene Chr6:86427217-86445746 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028548
protein coding gene Chr6:79285976-79303401 (+)
CAST/EiJ MGP_CASTEiJ_G0030011
protein coding gene Chr6:83265428-83282505 (+)
CBA/J MGP_CBAJ_G0030589
protein coding gene Chr6:89840810-89860268 (+)
DBA/2J MGP_DBA2J_G0030742
protein coding gene Chr6:80246836-80263975 (+)
FVB/NJ MGP_FVBNJ_G0030695
protein coding gene Chr6:79454221-79471510 (+)
LP/J MGP_LPJ_G0030821
protein coding gene Chr6:84134365-84152801 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030731
protein coding gene Chr6:94155435-94173597 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031386
protein coding gene Chr6:83075057-83094004 (+)
PWK/PhJ MGP_PWKPhJ_G0029726
protein coding gene Chr6:79139707-79157674 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029554
protein coding gene Chr6:81918638-81936561 (+)
WSB/EiJ MGP_WSBEiJ_G0030092
protein coding gene Chr6:83510629-83529341 (+)



Homology
more
  • Human Ortholog
    RTKN, rhotekin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RTKN, rhotekin
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 6242
    neXtProt AC: NX_Q9BST9
    UniProt: Q9BST9

  • Chr Location
    2p13.1; chr2:74425861-74441933 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7522
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RTKN
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034930 Ensembl Gene Model | MGI Sequence Detail 17117 C57BL/6J ±  kb
transcript ENSMUST00000065512 Ensembl | MGI Sequence Detail 2191 Not Applicable  
polypeptide ENSMUSP00000065571 Ensembl | MGI Sequence Detail 564 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 96
    Genomic 2
    cDNA 93
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-35838
References
more
  • Summaries
    All 43
    Developmental Gene Expression 2
    Gene Ontology 12
    Phenotypes 4
  • Earliest
    J:33389 Reid T, et al., Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain. J Biol Chem. 1996 Jun 7;271(23):13556-60
  • Latest
    J:187542 Zhou C, et al., Effect of cancer-associated mutations in the PlexinB1 gene. Mol Cancer. 2012;11:11

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory