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Stxbp2
Gene Detail
 Symbol
Name
ID
Stxbp2
syntaxin binding protein 2
MGI:107370
Synonyms C79054, Munc-18-2, Munc18b, Munc-18b, muSec1, Sxtp2
Feature Type protein coding gene
Genetic Map
Chromosome 8
1.92 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:3630955-3643644 bp, + strand
From VEGA annotation of GRCm38

  12690 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55530  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: VPS45_Sec1
Gene Tree: Stxbp2

Human
homologs
Human Homolog STXBP2, syntaxin binding protein 2
NCBI Gene ID 6813
neXtProt AC  NX_Q15833
Human Synonyms  FHL5, Hunc18b, MUNC18-2, pp10122, UNC18-2, UNC18B
Human Chr (Location)  19p13.3-p13.2; chr19:7637101-7647874 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human STXBP2
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit complete preweaning lethality. Mice heterozygous for this allele exhibit decreased stimulated mucin secretion, release of histones in stimulated mast cells and decreased susceptibility to type I hypersensitivity reaction.
 
Interactions
Stxbp2 interacts with 127 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process exocytosis, leukocyte mediated cytotoxicity, ...
Component apical plasma membrane, azurophil granule, ...
Function syntaxin-1 binding, syntaxin-3 binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (426)    Tissues (68)    Images (29)
Theiler Stages: 22, 23, 25
Assay TypeResults
RNA in situ 426
cDNA source data(101)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(102) cDNA(102)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000027109 (Evidence)
Ensembl Gene ModelENSMUSG00000004626 (Evidence)
Entrez Gene20911 (Evidence)
UniGene7247
DFCITC1574197, TC1681375, TC1732897
DoTSDT.533076, DT.91424123, DT.94389728
NIA Mouse Gene IndexU009028
Consensus CDS ProjectCCDS22067.1
International Mouse Knockout Project StatusStxbp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027109 VEGA Gene Model | MGI Sequence Detail 12690 C57BL/6J ±  kb
transcript OTTMUST00000067053 VEGA | MGI Sequence Detail 1847 Not Applicable 
polypeptide OTTMUSP00000033687 VEGA | MGI Sequence Detail 594 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(12) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(122 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027482 Sec1-like, domain 2
InterPro IPR001619 Sec1-like protein
Protein Ontology PR:000015801 syntaxin-binding protein 2
References (Earliest) J:23761 Katagiri H, et al., A novel isoform of syntaxin-binding protein homologous to yeast Sec1 expressed ubiquitously in mammalian cells. J Biol Chem. 1995 Mar 10;270(10):4963-6
(Latest) J:188931 Kim K, et al., Munc18b is an essential gene in mice whose expression is limiting for secretion by airway epithelial and mast cells. Biochem J. 2012 Sep 15;446(3):383-94
All references(48)
Other
accession IDs
MGD-MRK-33866, MGD-MRK-35837, MGI:2142858

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory