Il17a MGI Mouse Gene Detail - MGI:107364

Symbol

Il17a
Name

interleukin 17A
Synonyms

Ctla-8, Ctla8, Il17, IL-17A

Feature Type

protein coding gene
IDs

MGI:107364
NCBI Gene: 16171
Alliance

genome feature page
Transcription Start Sites

1 TSS
Regulated by

Rr17 (1 regulatory region)

Sequence Map

Chr1:20801129-20804720 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 6.45 cM, cytoband A
Mapping Data

3 experiments

SNPs within 2kb

240 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107364	protein coding gene	Chr1:20801129-20804720 (+)
129S1/SvImJ	ENSMUSG00200018441	protein coding gene	Chr1:18200513-18204101 (+)
A/J	ENSMUSG00195027280	protein coding gene	Chr1:17971157-17974747 (+)
AKR/J	ENSMUSG00220008155	protein coding gene	Chr1:18014800-18018390 (+)
BALB/cJ	ENSMUSG00180022599	protein coding gene	Chr1:18037390-18040980 (+)
C3H/HeJ	ENSMUSG00175000181	protein coding gene	Chr1:17966680-17970270 (+)
C57BL/6NJ	ENSMUSG00215007899	protein coding gene	Chr1:18051458-18055048 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0013982	protein coding gene	Chr1:16273365-16276959 (+)
CAST/EiJ	ENSTCUG00005021924	protein coding gene	Chr1:18269930-18273525 (+)
CBA/J	ENSMUSG00210002711	protein coding gene	Chr1:17843044-17846634 (+)
DBA/2J	ENSMUSG00185003761	protein coding gene	Chr1:18887290-18890880 (+)
FVB/NJ	ENSMUSG00205013152	protein coding gene	Chr1:17967820-17971409 (+)
JF1/MsJ	ENSUMUG00000014509	protein coding gene	Chr1:18096242-18099838 (+)
LP/J	ENSMUSG00230018822	protein coding gene	Chr1:18891921-18895509 (+)
NOD/ShiLtJ	ENSMUSG00190025208	protein coding gene	Chr1:17948858-17952448 (+)
NZO/HlLtJ	ENSMUSG00225000318	protein coding gene	Chr1:22266725-22270315 (+)
PWK/PhJ	ENSLUMG00010021678	protein coding gene	Chr1:17729186-17732783 (+)
SPRET/EiJ	ENSMSPG00010024595	protein coding gene	Chr1:18618279-18621850 (+)
WSB/EiJ	ENSIUOG00005011492	protein coding gene	Chr1:17935662-17939252 (+)

Human Ortholog

IL17A, interleukin 17A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL17A, interleukin 17A
Synonyms

CTLA-8, CTLA8, IL-17, IL17, IL-17A, ILA17
Links

HGNC:5981

NCBI Gene ID: 3605

UniProt: Q16552
Chr Location

6p12.2; chr6:52186375-52190638 (+) GRCh38

MGI Vertebrate Homology

Il17a stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: IL17A
Gene Tree

Il17a

Diseases

14 with human IL17A associations

				Human Disease	Mouse Models
				allergic rhinitis IDs allergic rhinitis DOID:4481 DOID:12089 DOID:14030 DOID:8241 DOID:8242 EFO:0003956 NCI:C34987 OMIM:607154 UMLS_CUI:C0002103
				ankylosing spondylitis IDs ankylosing spondylitis DOID:7147 EFO:0003898 ICD10CM:M45 ICD9CM:720.0 MESH:D013167 NCI:C84564 OMIM:PS106300 ORDO:825 UMLS_CUI:C0038013
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				bronchiolitis IDs bronchiolitis DOID:2942 MESH:D001988 NCI:C39658 UMLS_CUI:C0006271
				childhood-onset asthma IDs childhood-onset asthma DOID:0080815
				Graves' disease IDs Graves' disease DOID:12361 EFO:0004237 ICD10CM:E05.0 MESH:D006111 NCI:C3071 OMIM:275000 UMLS_CUI:C0018213
				macular degeneration IDs macular degeneration DOID:4448 MESH:D008268 NCI:C123330 ORDO:279 UMLS_CUI:C0024437
				Mycobacterium avium complex disease IDs Mycobacterium avium complex disease DOID:2755 MESH:D015270 NCI:C36197 UMLS_CUI:C0026916
				psoriasis IDs psoriasis DOID:8893 EFO:0000676 ICD10CM:L40 MESH:D011565 NCI:C3346 OMIM:PS177900 UMLS_CUI:C0033860
				psoriatic arthritis IDs psoriatic arthritis DOID:9008 EFO:0003778 ICD10CM:L40.5 ICD9CM:696.0 MESH:D015535 NCI:C61277 UMLS_CUI:C0003872
				pulmonary tuberculosis IDs pulmonary tuberculosis DOID:2957 ICD10CM:A15 ICD9CM:011 ICD9CM:011.9 ICD9CM:011.90 MESH:D014397 NCI:C26899 UMLS_CUI:C0041327
				rheumatoid arthritis IDs rheumatoid arthritis DOID:7148 EFO:0000685 ICD10CM:M06.9 ICD9CM:714.0 KEGG:05323 MESH:D001172 NCI:C2884 OMIM:180300 UMLS_CUI:C0003873
				rhinitis IDs rhinitis DOID:4483 MESH:D012220 NCI:C34986 UMLS_CUI:C0035455
				temporal arteritis IDs temporal arteritis DOID:13375 ICD9CM:446.5 MESH:D013700 NCI:C35065 OMIM:187360 ORDO:397 UMLS_CUI:C0039483

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

49 phenotypes from 7 alleles in 10 genetic backgrounds
27 phenotypes from multigenic genotypes
1 images
669 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Endonuclease-mediated

15
Targeted

14
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygotes for a targeted null mutation exhibit reduced contact, delayed-type and airway hypersensitivity responses and impaired T-dependent antibody production.

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All GO Annotations

68
GO References

27

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

607
Tissues

5
cDNA Data

10
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

2
UniProt

2
CCDS

CCDS14842.1

Ensembl

ENSMUSG00000025929 (Evidence)
NCBI Gene

16171

			Length	Strain/Species	Flank
genomic	16171	NCBI Gene Model \| MGI Sequence Detail	3592	C57BL/6J	± kb
transcript	NM_010552	RefSeq \| MGI Sequence Detail	1171	C57BL/6
polypeptide	Q62386	UniProt \| EBI \| MGI Sequence Detail	158	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001138 interleukin-17A

(term hierarchy)
InterPro Domains

IPR029034 Cystine-knot cytokine

IPR020440 Interleukin-17, chordata

IPR010345 Interleukin-17 family
GlyGen

Q62386 1 site

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All nucleic 15

Genomic 2

cDNA 10

Primer pair 3

Microarray probesets 5

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MGD-MRK-2228, MGD-MRK-2238, MGD-MRK-35831

Summaries

All 1320

Developmental Gene Expression 6

Gene Ontology 27

Phenotypes 669
Earliest

J:12608 Rouvier E, et al., CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J Immunol. 1993 Jun 15;150(12):5445-56
Latest

J:391716 Kishikawa S, et al., Interleukin-17A-producing gammadelta T cells drive cognitive dysfunction in periodontitis. Cell Rep. 2026 Aug 27;45(9):117903

Il17a expression regulated by:

Feature	Feature Type	Location	Reference
Rr17, regulatory region 17	enhancer	Chr1:20795018-20797983	J:181186

TSS for Il17a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6053	Chr1:20801127-20801132 (+)	1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24