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Stxbp1 Gene Detail
Summary
  • Symbol
    Stxbp1
  • Name
    syntaxin binding protein 1
  • Synonyms
    Munc18-1, Munc-18a, nsec1, N-sec1, Rb-sec1, Sxtbp1, Unc18h
  • Feature Type
    protein coding gene
  • IDs
    MGI:107363
    NCBI Gene: 20910
  • Gene Overview
    MyGene.info: STXBP1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:32787607-32847237 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 22.09 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    241 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107363
protein coding gene Chr2:32787602-32847245 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025625
protein coding gene Chr2:31281091-31343880 (-)
A/J MGP_AJ_G0025602
protein coding gene Chr2:29944202-30004368 (-)
AKR/J MGP_AKRJ_G0025572
protein coding gene Chr2:31018740-31080750 (-)
BALB/cJ MGP_BALBcJ_G0025599
protein coding gene Chr2:30063130-30123847 (-)
C3H/HeJ MGP_C3HHeJ_G0025359
protein coding gene Chr2:30901007-30962571 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026043
protein coding gene Chr2:32220845-32285036 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023452
protein coding gene Chr2:28663955-28725530 (-)
CAST/EiJ MGP_CASTEiJ_G0024821
protein coding gene Chr2:30855130-30915889 (-)
CBA/J MGP_CBAJ_G0025337
protein coding gene Chr2:33451714-33515520 (-)
DBA/2J MGP_DBA2J_G0025470
protein coding gene Chr2:29706106-29767380 (-)
FVB/NJ MGP_FVBNJ_G0025432
protein coding gene Chr2:29594194-29654056 (-)
LP/J MGP_LPJ_G0025556
protein coding gene Chr2:31154593-31220483 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025463
protein coding gene Chr2:33068399-33129718 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026101
protein coding gene Chr2:30887140-30948848 (-)
PWK/PhJ MGP_PWKPhJ_G0024569
protein coding gene Chr2:29615250-29676967 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024369
protein coding gene Chr2:31045968-31106312 (-)
WSB/EiJ MGP_WSBEiJ_G0024890
protein coding gene Chr2:31076521-31139596 (-)



Homology
more
  • Human Ortholog
    STXBP1, syntaxin binding protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STXBP1, syntaxin binding protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MUNC18-1, NSEC1, P67, RBSEC1, UNC18
  • Links
    NCBI Gene ID: 6812
    neXtProt AC: NX_P61764
    UniProt: P61764

  • Chr Location
    9q34.11; chr9:127612207-127692716 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit total loss of neurotransmitter secretion from synaptic vesicles throughout development and massive neuron apoptosis after initial synaptogenesis, leading to widespread neurodegeneration and complete neonatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20910 NCBI Gene Model | MGI Sequence Detail 59631 C57BL/6J ±  kb
    transcript NM_001113569 RefSeq | MGI Sequence Detail 4005 C57BL/6  
    polypeptide O08599 UniProt | EBI | MGI Sequence Detail 594 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 144
      Genomic 7
      cDNA 137

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33867, MGD-MRK-35830, MGI:1306809, MGI:2138896, MGI:2138910
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 17
      Gene Ontology 24
      Phenotypes 34
    • Earliest
      J:23761 Katagiri H, et al., A novel isoform of syntaxin-binding protein homologous to yeast Sec1 expressed ubiquitously in mammalian cells. J Biol Chem. 1995 Mar 10;270(10):4963-6
    • Latest
      J:263883 Gutierrez BA, et al., Munc18-2, but not Munc18-1 or Munc18-3, controls compound and single-vesicle-regulated exocytosis in mast cells. J Biol Chem. 2018 May 11;293(19):7148-7159

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory