Stxbp3a
Gene Detail

Symbol Name ID

Stxbp3a syntaxin binding protein 3A MGI:107362

Synonyms

Munc-18c, Sxtbp3

Feature Type

protein coding gene

Genetic Map

Chromosome 3

47.73 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr3:108793176-108840526 bp, - strand From VEGA annotation of GRCm38   47351 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5260  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: VPS45_Sec1
Gene Tree: Stxbp3a

Human homologs

Human Homolog		STXBP3, syntaxin binding protein 3
NCBI Gene ID		6814
neXtProt AC		NX_O00186
Human Synonyms		MUNC18-3, MUNC18C, PSP, UNC-18C
Human Chr (Location)		1p13.3; chr1:109289285-109352148 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Homozygous null mice display embryonic or perinatal lethality with reduced embryonic growth and malformation of the intermediate zone of the cerebral cortex.

 

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	brain development, exocytosis, ...
Component	apical plasma membrane, basolateral plasma membrane, ...
Function	protein binding, syntaxin-1 binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (1)    Images (1)
Theiler Stages: 17

Assay Type	Results
Western blot	4

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(13)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000007265 (Evidence)
Ensembl Gene Model	ENSMUSG00000027882 (Evidence)
Entrez Gene	20912 (Evidence)
PDB	2PJX, 3PUK
Consensus CDS Project	CCDS17768.1
International Mouse Knockout Project Status	Stxbp3a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000007265	VEGA Gene Model | MGI Sequence Detail	47351	C57BL/6J
transcript	OTTMUST00000016776	VEGA | MGI Sequence Detail	2419	Not Applicable
polypeptide	OTTMUSP00000007729	VEGA | MGI Sequence Detail	592	Not Applicable

All sequences(34) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(265 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR027482	Sec1-like, domain 2
InterPro	IPR001619	Sec1-like protein
Protein Ontology	PR:000015802	syntaxin-binding protein 3

References

(Earliest) J:13914 Erickson R, et al., Sts variant. Mouse News Lett. 1982;66:69
(Latest) J:186997 Jain SS, et al., Munc18c provides stimulus-selective regulation of GLUT4 but not fatty acid transporter trafficking in skeletal muscle. FEBS Lett. 2012 Jul 30;586(16):2428-35
All references(37)

Other accession IDs

MGD-MRK-33865, MGD-MRK-35828