About   Help   FAQ
Stxbp3 Gene Detail
Summary
  • Symbol
    Stxbp3
  • Name
    syntaxin binding protein 3
  • Synonyms
    Munc-18c, Stxbp3a
  • Feature Type
    protein coding gene
  • IDs
    MGI:107362
    NCBI Gene: 20912
  • Gene Overview
    MyGene.info: STXBP3
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:108793180-108840502 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 47.73 cM, cytoband F3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    308 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107362
protein coding gene Chr3:108793176-108840526 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027786
protein coding gene Chr3:110374400-110421656 (-)
A/J MGP_AJ_G0027746
protein coding gene Chr3:106867049-106916832 (-)
AKR/J MGP_AKRJ_G0027711
protein coding gene Chr3:109467742-109518037 (-)
BALB/cJ MGP_BALBcJ_G0027758
protein coding gene Chr3:106567469-106617528 (-)
C3H/HeJ MGP_C3HHeJ_G0027488
protein coding gene Chr3:109824371-109873933 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028202
protein coding gene Chr3:114463941-114517565 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025540
protein coding gene Chr3:102994069-103042510 (-)
CAST/EiJ MGP_CASTEiJ_G0026944
protein coding gene Chr3:109217568-109265219 (-)
CBA/J MGP_CBAJ_G0027463
protein coding gene Chr3:118380271-118436814 (-)
DBA/2J MGP_DBA2J_G0027605
protein coding gene Chr3:106039121-106086071 (-)
FVB/NJ MGP_FVBNJ_G0027573
protein coding gene Chr3:103925040-103971636 (-)
LP/J MGP_LPJ_G0027712
protein coding gene Chr3:111791932-111846660 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027603
protein coding gene Chr3:124423818-124486756 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028257
protein coding gene Chr3:109066082-109119977 (-)
PWK/PhJ MGP_PWKPhJ_G0026670
protein coding gene Chr3:105794385-105841827 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026490
protein coding gene Chr3:107212316-107264442 (-)
WSB/EiJ MGP_WSBEiJ_G0027024
protein coding gene Chr3:109603370-109654119 (-)



Homology
more
  • Human Ortholog
    STXBP3, syntaxin binding protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STXBP3, syntaxin binding protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MUNC18-3, MUNC18C, PSP, UNC-18C
  • Links
    NCBI Gene ID: 6814
    neXtProt AC: NX_O00186
    UniProt: O00186

  • Chr Location
    1p13.3; chr1:108746663-108809526 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic or perinatal lethality with reduced embryonic growth and malformation of the intermediate zone of the cerebral cortex.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20912 NCBI Gene Model | MGI Sequence Detail 47323 C57BL/6J ±  kb
    transcript NM_011504 RefSeq | MGI Sequence Detail 2406 BALB/c  
    polypeptide Q60770 UniProt | EBI | MGI Sequence Detail 592 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33865, MGD-MRK-35828
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 15
      Phenotypes 9
    • Earliest
      J:28512 Tellam JT, et al., Molecular identification of two novel Munc-18 isoforms expressed in non-neuronal tissues. J Biol Chem. 1995 Mar 17;270(11):5857-63
    • Latest
      J:263883 Gutierrez BA, et al., Munc18-2, but not Munc18-1 or Munc18-3, controls compound and single-vesicle-regulated exocytosis in mast cells. J Biol Chem. 2018 May 11;293(19):7148-7159

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory