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Stxbp3 Gene Detail
Summary
  • Symbol
    Stxbp3
  • Name
    syntaxin binding protein 3
  • Synonyms
    Munc-18c, Stxbp3a
  • Feature Type
    protein coding gene
  • IDs
    MGI:107362
    NCBI Gene: 20912
  • Gene Overview
    MyGene.info: STXBP3
Location & Maps
more
  • Sequence Map
    Chr3:108793176-108840526 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      47351 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    STXBP3, syntaxin binding protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STXBP3, syntaxin binding protein 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MUNC18-3, MUNC18C, PSP, UNC-18C
  • Links
    NCBI Gene ID: 6814
    neXtProt AC: NX_O00186

  • Chr Location
    1p13.3; chr1:108746663-108809526 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Stxbp3
  • Incidental Mutations
Homozygous null mice display embryonic or perinatal lethality with reduced embryonic growth and malformation of the intermediate zone of the cerebral cortex.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007265 VEGA Gene Model | MGI Sequence Detail 47351 C57BL/6J ±  kb
transcript OTTMUST00000016776 VEGA | MGI Sequence Detail 2419 Not Applicable  
polypeptide OTTMUSP00000007729 VEGA | MGI Sequence Detail 592 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    308 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-33865, MGD-MRK-35828
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 11
    Phenotypes 8
  • Earliest
    J:13914 Erickson R, et al., Sts variant. Mouse News Lett. 1982;66:69
  • Latest
    J:186997 Jain SS, et al., Munc18c provides stimulus-selective regulation of GLUT4 but not fatty acid transporter trafficking in skeletal muscle. FEBS Lett. 2012 Jul 30;586(16):2428-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory