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Stxbp3
Gene Detail
Symbol

Name
ID
Stxbp3
syntaxin binding protein 3
MGI:107362
Synonyms
Munc-18c, Stxbp3a
Feature Type
protein coding gene
Genetic Map
Chromosome 3
47.73 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:108793176-108840526 bp, - strand
From VEGA annotation of GRCm38

  47351 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5260  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: STXBP3
Protein SuperFamily: VPS45_Sec1
Gene Tree: Stxbp3

Human
homologs
STXBP3, syntaxin binding protein 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6814
neXtProt AC: NX_O00186

Human Synonyms: MUNC18-3, MUNC18C, PSP, UNC-18C

Human Chr (Location): 1p13.3; chr1:108746663-108809526 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic or perinatal lethality with reduced embryonic growth and malformation of the intermediate zone of the cerebral cortex.
 
Interactions
Stxbp3 interacts with 201 markers (Mir1b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process brain development, exocytosis, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function protein binding, syntaxin-1 binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 4
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000007265 (Evidence)
Ensembl Gene Model ENSMUSG00000027882 (Evidence)
Entrez Gene 20912 (Evidence)
PDB 3PUK
Consensus CDS Project CCDS17768.1
International Mouse Phenotyping Consortium Status Stxbp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007265 VEGA Gene Model | MGI Sequence Detail 47351 C57BL/6J ±  kb
transcript OTTMUST00000016776 VEGA | MGI Sequence Detail 2419 Not Applicable 
polypeptide OTTMUSP00000007729 VEGA | MGI Sequence Detail 592 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(308 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027482 Sec1-like, domain 2
InterPro IPR001619 Sec1-like protein
Protein Ontology PR:000015802 syntaxin-binding protein 3
References
(Earliest) J:13914 Erickson R, et al., Sts variant. Mouse News Lett. 1982;66:69
(Latest) J:186997 Jain SS, et al., Munc18c provides stimulus-selective regulation of GLUT4 but not fatty acid transporter trafficking in skeletal muscle. FEBS Lett. 2012 Jul 30;586(16):2428-35
All references(36)
Other
accession IDs
MGD-MRK-33865, MGD-MRK-35828

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory