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Bmp8b Gene Detail
Summary
  • Symbol
    Bmp8b
  • Name
    bone morphogenetic protein 8b
  • Synonyms
    Op3
  • Feature Type
    protein coding gene
  • IDs
    MGI:107335
    NCBI Gene: 12164
  • Gene Overview
    MyGene.info: BMP8B
Location & Maps
more
  • Sequence Map
    Chr4:123105165-123132099 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26935 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    BMP8B, bone morphogenetic protein 8b
  • Vertebrate Orthologs
    2
  • Human Ortholog
    BMP8B, bone morphogenetic protein 8b
    Orthology source: HGNC
  • Synonyms
    BMP8, OP2
  • Links
    NCBI Gene ID: 656
    neXtProt AC: NX_P34820

  • Chr Location
    1p35-p32; chr1:39757182-39788861 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 1 allele in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    4 involving Bmp8b
  • Incidental Mutations
Incidence of lethality among homozygous null mutants is variable depending on genetic background and due to allantoic and embryonic abnormalities. Heterozygous and surviving homozygous males exhibit varying degrees of germ cell deficiency and infertility, also background dependent.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008937 VEGA Gene Model | MGI Sequence Detail 26935 C57BL/6J ±  kb
transcript OTTMUST00000020302 VEGA | MGI Sequence Detail 2940 Not Applicable  
polypeptide OTTMUSP00000009313 VEGA | MGI Sequence Detail 399 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    126 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
  • InterPro Domains
    IPR029034 Cystine-knot cytokine
    IPR017948 Transforming growth factor beta, conserved site
    IPR001839 Transforming growth factor-beta, C-terminal
    IPR001111 Transforming growth factor-beta, N-terminal
    IPR015615 Transforming growth factor-beta-related
Molecular
Reagents
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  • All nucleic 19
    Genomic 5
    cDNA 12
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-35801
References
more
  • Summaries
    All 48
    Developmental Gene Expression 15
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:34057 Zhao GQ, et al., The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse. Genes Dev. 1996 Jul 1;10(13):1657-69
  • Latest
    J:202012 Pandey RR, et al., Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16492-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory