Bmp8b
Gene Detail

Symbol Name ID

Bmp8b bone morphogenetic protein 8b MGI:107335

Synonyms

Op3

Feature Type

protein coding gene

Genetic Map

Chromosome 4

57.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr4:123105165-123132099 bp, + strand From VEGA annotation of GRCm38   26935 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:130625  Vertebrate Homology Class
1 mouse; 1 rat

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Bmp8b

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Incidence of lethality among homozygous null mutants is variable depending on genetic background and due to allantoic and embryonic abnormalities. Heterozygous and surviving homozygous males exhibit varying degrees of germ cell deficiency and infertility, also background dependent.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	cartilage development, cell differentiation, ...
Component	extracellular region, extracellular space
Function	cytokine activity, growth factor activity

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (33)    Tissues (24)    Images (4)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	24
RT-PCR	9

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) Genomic(5) cDNA(11) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000008937 (Evidence)
Ensembl Gene Model	ENSMUSG00000002384 (Evidence)
Entrez Gene	12164 (Evidence)
UniGene	439764
DFCI	TC1587920, TC1616736
DoTS	DT.91329852, DT.91444403
NIA Mouse Gene Index	U004765
Consensus CDS Project	CCDS18608.1
International Mouse Knockout Project Status	Bmp8b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008937	VEGA Gene Model | MGI Sequence Detail	26935	C57BL/6J
transcript	OTTMUST00000020302	VEGA | MGI Sequence Detail	2940	Not Applicable
polypeptide	OTTMUSP00000009313	VEGA | MGI Sequence Detail	399	Not Applicable

All sequences(24) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(90 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017948	Transforming growth factor beta, conserved site
InterPro	IPR001839	Transforming growth factor-beta, C-terminal
InterPro	IPR001111	Transforming growth factor-beta, N-terminal
InterPro	IPR015615	Transforming growth factor-beta-related
Protein Ontology	PR:000000170	BMP8B

References

(Earliest) J:34057 Zhao GQ, et al., The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse. Genes Dev. 1996 Jul 1;10(13):1657-69
(Latest) J:186179 Whittle AJ, et al., BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell. 2012 May 11;149(4):871-85
All references(50)

Other accession IDs

MGD-MRK-35801