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Bmp8b Gene Detail
Summary
  • Symbol
    Bmp8b
  • Name
    bone morphogenetic protein 8b
  • Synonyms
    Op3
  • Feature Type
    protein coding gene
  • IDs
    MGI:107335
    NCBI Gene: 12164
  • Gene Overview
    MyGene.info: BMP8B
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:123104307-123126094 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 57.38 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    102 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107335
protein coding gene Chr4:123104307-123132099 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028732
protein coding gene Chr4:124511782-124553878 (+)
A/J MGP_AJ_G0028691
protein coding gene Chr4:119657284-119691645 (+)
AKR/J MGP_AKRJ_G0028645
protein coding gene Chr4:122887541-122923892 (+)
BALB/cJ MGP_BALBcJ_G0028714
protein coding gene Chr4:120243184-120273270 (+)
C3H/HeJ MGP_C3HHeJ_G0028429
protein coding gene Chr4:123008642-123036673 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029156
protein coding gene Chr4:129339310-129370077 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026429
protein coding gene Chr4:112885827-112912173 (+)
CAST/EiJ MGP_CASTEiJ_G0027861
protein coding gene Chr4:121006659-121051802 (+)
CBA/J MGP_CBAJ_G0028396
protein coding gene Chr4:132613403-132656324 (+)
DBA/2J MGP_DBA2J_G0028543
protein coding gene Chr4:120163453-120196634 (+)
FVB/NJ MGP_FVBNJ_G0028510
protein coding gene Chr4:118778698-118815067 (+)
LP/J MGP_LPJ_G0028644
protein coding gene Chr4:124802216-124833280 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028538
protein coding gene Chr4:137560877-137598561 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029193
protein coding gene Chr4:123255730-123303420 (+)
PWK/PhJ MGP_PWKPhJ_G0027584
protein coding gene Chr4:116559554-116588053 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027409
protein coding gene Chr4:119068617-119109946 (+)
WSB/EiJ MGP_WSBEiJ_G0027941
protein coding gene Chr4:123350427-123380805 (+)



Homology
more
  • Human Ortholog
    BMP8B, bone morphogenetic protein 8b
  • Vertebrate Orthologs
    2
  • Human Ortholog
    BMP8B, bone morphogenetic protein 8b
    Orthology source: HGNC
  • Synonyms
    BMP8, OP2
  • Links
    NCBI Gene ID: 656
    neXtProt AC: NX_P34820
    UniProt: P34820

  • Chr Location
    1p34.2; chr1:39757182-39788861 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 1 allele in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Incidence of lethality among homozygous null mutants is variable depending on genetic background and due to allantoic and embryonic abnormalities. Heterozygous and surviving homozygous males exhibit varying degrees of germ cell deficiency and infertility, also background dependent.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12164 NCBI Gene Model | MGI Sequence Detail 21788 C57BL/6J ±  kb
    transcript NM_007559 RefSeq | MGI Sequence Detail 2965 C57BL/6  
    polypeptide P55105 UniProt | EBI | MGI Sequence Detail 399 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 5
      cDNA 13
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35801
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 15
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:34057 Zhao GQ, et al., The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse. Genes Dev. 1996 Jul 1;10(13):1657-69
    • Latest
      J:238940 Martins L, et al., A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance. Cell Rep. 2016 Aug 23;16(8):2231-42

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory