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Bmp8b
Gene Detail
 Symbol
Name
ID
Bmp8b
bone morphogenetic protein 8b
MGI:107335
Synonyms Op3
Feature Type protein coding gene
Genetic Map
Chromosome 4
57.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:123105165-123132099 bp, + strand
From VEGA annotation of GRCm38

  26935 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:130625  Vertebrate Homology Class
1 mouse; 1 rat

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Bmp8b

Alleles
and
phenotypes
All alleles(4) : Targeted(4)
 
Incidence of lethality among homozygous null mutants is variable depending on genetic background and due to allantoic and embryonic abnormalities. Heterozygous and surviving homozygous males exhibit varying degrees of germ cell deficiency and infertility, also background dependent.
 
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cartilage development, cell differentiation, ...
Component extracellular region, extracellular space
Function cytokine activity, growth factor activity
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (40)    Tissues (31)    Images (5)
Theiler Stages: 8, 9, 11, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 31
RT-PCR 9
cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(19) Genomic(5) cDNA(12) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000008937 (Evidence)
Ensembl Gene ModelENSMUSG00000002384 (Evidence)
Entrez Gene12164 (Evidence)
UniGene439764
DFCITC1587920, TC1616736
DoTSDT.91329852, DT.91444403
NIA Mouse Gene IndexU004765
Consensus CDS ProjectCCDS18608.1
International Mouse Knockout Project StatusBmp8b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008937 VEGA Gene Model | MGI Sequence Detail 26935 C57BL/6J ±  kb
transcript OTTMUST00000020302 VEGA | MGI Sequence Detail 2940 Not Applicable 
polypeptide OTTMUSP00000009313 VEGA | MGI Sequence Detail 399 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(146 from dbSNP Build 137)    SNPs within 2kb including multiple locations(182)
Protein-related
information
ResourceIDDescription
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000170 BMP8B
References (Earliest) J:34057 Zhao GQ, et al., The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse. Genes Dev. 1996 Jul 1;10(13):1657-69
(Latest) J:186179 Whittle AJ, et al., BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell. 2012 May 11;149(4):871-85
All references(50)
Other
accession IDs
MGD-MRK-35801

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory