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Man2b1
Gene Detail
 Symbol
Name
ID
Man2b1
mannosidase 2, alpha B1
MGI:107286
Synonyms lysosomal alpha-mannosidase
Feature Type protein coding gene
Genetic Map
Chromosome 8
41.55 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:85083269-85098739 bp, + strand
From NCBI annotation of GRCm38

  15471 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37322  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: lysosomal alpha-mannosidase
Gene Tree: Man2b1

Human
homologs
Human Homolog MAN2B1, mannosidase, alpha, class 2B, member 1
NCBI Gene ID 4125
neXtProt AC  NX_O00754
Human Synonyms  LAMAN, MANB
Human Chr (Location)  19p13.2; chr19:12646508-12666777 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MAN2B1
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show urinary oligosaccharide excretion, storage of neutral sugars, oligosaccharide buildup in spleen, kidney, liver, testis and brain, clear vacuoles and axonal spheroids in CNS, PNS and other cell types, behavioral changes, and enhanced long-term potentiation.
 
Human Diseases Modeled Using Mouse Man2b1 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process carbohydrate metabolic process, cellular protein modification process, ...
Component extracellular vesicular exosome, lysosome
Function alpha-mannosidase activity, carbohydrate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (149)    Tissues (145)    Images (20)
Theiler Stages: 22, 26, 28
Assay TypeResults
RNA in situ 143
Northern blot 6
cDNA source data(174)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(181) Genomic(4) cDNA(175) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000005142 (Evidence)
Entrez Gene17159 (Evidence)
UniGene4219
DFCITC1572168, TC1650181, TC1663954, TC1675900, TC1695941
DoTSDT.102558256, DT.110856005, DT.40151161, DT.536195, DT.87060221
NIA Mouse Gene IndexU168133
EC3.2.1.24
Consensus CDS ProjectCCDS22494.1
International Mouse Knockout Project StatusMan2b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17159 NCBI Gene Model | MGI Sequence Detail 15471 C57BL/6J ±  kb
transcript NM_010764 RefSeq | MGI Sequence Detail 4326 C57BL/6 
polypeptide O09159 UniProt | EBI | MGI Sequence Detail 1013 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(8) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(118 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011013 Galactose mutarotase-like domain
InterPro IPR027291 Glycoside hydrolase 38/57, N-terminal domain
InterPro IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
InterPro IPR015341 Glycoside hydrolase, family 38, central domain
InterPro IPR000602 Glycoside hydrolase family 38, N-terminal domain
InterPro IPR013780 Glycosyl hydrolase, family 13, all-beta
InterPro IPR011682 Glycosyl hydrolase family 38, C-terminal
Protein Ontology PR:000010107 lysosomal alpha-mannosidase
Graphical View of Protein Domain Structure
References (Earliest) J:35468 Beccari T, et al., Assignment of lysosomal alpha-D-mannosidase to mouse Chromosome 8. Mamm Genome. 1996 Sep;7(9):707-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(45)
Other
accession IDs
MGD-MRK-35751, MGI:2142759

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory