Man2b1
Gene Detail

Symbol Name ID

Man2b1 mannosidase 2, alpha B1 MGI:107286

Synonyms

lysosomal alpha-mannosidase

Feature Type

protein coding gene

Genetic Map

Chromosome 8

41.55 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr8:85083269-85098739 bp, + strand From NCBI annotation of GRCm38   15471 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37322  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: lysosomal alpha-mannosidase
Gene Tree: Man2b1

Human homologs

Human Homolog		MAN2B1, mannosidase, alpha, class 2B, member 1
NCBI Gene ID		4125
neXtProt AC		NX_O00754
Human Synonyms		LAMAN, MANB
Human Chr (Location)		19cen-q13.1; chr19:12757322-12777591 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MAN2B1

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele show urinary oligosaccharide excretion, storage of neutral sugars, oligosaccharide buildup in spleen, kidney, liver, testis and brain, clear vacuoles and axonal spheroids in CNS, PNS and other cell types, behavioral changes, and enhanced long-term potentiation.

 
Human Diseases Modeled Using Mouse Man2b1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	carbohydrate metabolic process, cellular protein modification process, ...
Component	lysosome
Function	alpha-mannosidase activity, carbohydrate binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (100)    Tissues (96)    Images (18)
Theiler Stages: 22, 26, 28

Assay Type	Results
RNA in situ	94
Northern blot	6

cDNA source data(175)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(182) Genomic(4) cDNA(176) Primer pair(1) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000005142 (Evidence)
Entrez Gene	17159 (Evidence)
UniGene	4219
DFCI	TC1572168, TC1650181, TC1663954, TC1675900, TC1695941
DoTS	DT.102558256, DT.110856005, DT.40151161, DT.536195, DT.87060221
NIA Mouse Gene Index	U168133
EC	3.2.1.24
Consensus CDS Project	CCDS22494.1
International Mouse Knockout Project Status	Man2b1

Sequences

Length	Strain/Species
genomic	17159	NCBI Gene Model | MGI Sequence Detail	15471	C57BL/6J
transcript	NM_010764	RefSeq | MGI Sequence Detail	4326	C57BL/6
polypeptide	O09159	UniProt | EBI | MGI Sequence Detail	1013	Not Applicable

All sequences(71) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(62 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011330	Glycoside hydrolase/deacetylase, beta/alpha-barrel
InterPro	IPR015341	Glycoside hydrolase, family 38, central domain
InterPro	IPR000602	Glycoside hydrolase, family 38, core
InterPro	IPR011013	Glycoside hydrolase-type carbohydrate-binding
InterPro	IPR013780	Glycosyl hydrolase, family 13, all-beta
InterPro	IPR011682	Glycosyl hydrolase family 38, C-terminal
Protein Ontology	PR:000010107	lysosomal alpha-mannosidase

Graphical View of Protein Domain Structure

References

(Earliest) J:35468 Beccari T, et al., Assignment of lysosomal alpha-D-mannosidase to mouse Chromosome 8. Mamm Genome. 1996 Sep;7(9):707-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(44)

Other accession IDs

MGD-MRK-35751, MGI:2142759