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Ctsh Gene Detail
Summary
  • Symbol
    Ctsh
  • Name
    cathepsin H
  • Synonyms
    Cat H
  • Feature Type
    protein coding gene
  • IDs
    MGI:107285
    NCBI Gene: 13036
  • Gene Overview
    MyGene.info: CTSH
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:90054267-90076095 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 47.40 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    217 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107285
protein coding gene Chr9:90054152-90076095 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035119
protein coding gene Chr9:90980430-91008898 (+)
A/J MGP_AJ_G0035100
protein coding gene Chr9:87844162-87866766 (+)
AKR/J MGP_AKRJ_G0035032
protein coding gene Chr9:89907339-89929015 (+)
BALB/cJ MGP_BALBcJ_G0035092
protein coding gene Chr9:87494580-87517150 (+)
C3H/HeJ MGP_C3HHeJ_G0034803
protein coding gene Chr9:90357611-90381434 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035613
protein coding gene Chr9:93523495-93544965 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032516
protein coding gene Chr9:86026506-86047254 (+)
CAST/EiJ MGP_CASTEiJ_G0034115
protein coding gene Chr9:90135296-90157605 (+)
CBA/J MGP_CBAJ_G0034771
protein coding gene Chr9:96763158-96789592 (+)
DBA/2J MGP_DBA2J_G0034933
protein coding gene Chr9:87389057-87411639 (+)
FVB/NJ MGP_FVBNJ_G0034879
protein coding gene Chr9:86415939-86437548 (+)
LP/J MGP_LPJ_G0035012
protein coding gene Chr9:91210420-91233720 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034920
protein coding gene Chr9:98374764-98415250 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035633
protein coding gene Chr9:90128553-90152222 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0033656
protein coding gene Chr9:90209075-90230357 (+)
WSB/EiJ MGP_WSBEiJ_G0034235
protein coding gene Chr9:90015335-90039640 (+)



Homology
more
  • Human Ortholog
    CTSH, cathepsin H
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CTSH, cathepsin H
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACC4, ACC-4, ACC5, ACC-5, CPSB
  • Links
    NCBI Gene ID: 1512
    neXtProt AC: NX_P09668
    UniProt: P09668

  • Chr Location
    15q25.1; chr15:78921750-78945098 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele exhibit impaired lung surfactant and an abnormal eye globe with elongated axial length.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13036 NCBI Gene Model | MGI Sequence Detail 21829 C57BL/6J ±  kb
    transcript NM_007801 RefSeq | MGI Sequence Detail 1630 C57BL/6  
    polypeptide P49935 UniProt | EBI | MGI Sequence Detail 333 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 205
      cDNA 203
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35750, MGI:2143173
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:12285 Wang X, et al., Chromosome assignment of cathepsin B CTSB to 8p22 and cathepsin H (CTSH) to 15q24-q25. Cytogenet Cell Genet. 1987;46:710-711
    • Latest
      J:238995 Yan D, et al., STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1alpha Activation. Cell Rep. 2016 Sep 13;16(11):2914-27

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory