Ctsh
Gene Detail

Symbol

Name
ID

Ctsh
cathepsin H
MGI:107285

Synonyms

Cat H

Feature Type

protein coding gene

Genetic Map

Chromosome 9
47.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr9:90054152-90076089 bp, + strand From VEGA annotation of GRCm38   21938 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:36159  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ctsh

Human
homologs

Human Homolog		CTSH, cathepsin H
NCBI Gene ID		1512
neXtProt AC		NX_P09668
Human Synonyms		ACC-4, ACC-5, CPSB, minichain
Human Chr (Location)		15q25.1; chr15:78921750-78945094 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a reporter allele exhibit impaired lung surfactant and an abnormal eye globe with elongated axial length.

 

Interactions

Ctsh interacts with 173 markers (Mir15a, Mir16-1, Mir19a, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (57 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component	acrosomal vesicle, alveolar lamellar body, ...
Function	aminopeptidase activity, cysteine-type endopeptidase activator activity involved in apoptotic process, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)

Data Summary: Results (30)    Tissues (19)    Images (3)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	26
RT-PCR	4

cDNA source data(202)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(204) cDNA(202) Primer pair(1) Other(1)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000024409 (Evidence)
Ensembl Gene Model	ENSMUSG00000032359 (Evidence)
Entrez Gene	13036 (Evidence)
UniGene	2277
DFCI	TC1572082, TC1622684
DoTS	DT.99864755, DT.494631, DT.110642551, DT.101257872, DT.101184564
NIA Mouse Gene Index	U010845
EC	3.4.22.16
Consensus CDS Project	CCDS23399.1
International Mouse Knockout Project Status	Ctsh

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024409	VEGA Gene Model | MGI Sequence Detail	21938	C57BL/6J
transcript	OTTMUST00000059829	VEGA | MGI Sequence Detail	1617	Not Applicable
polypeptide	OTTMUSP00000029135	VEGA | MGI Sequence Detail	333	Not Applicable

All sequences(71) RefSeq(2) UniProt(10)

Polymorphisms

RFLP(1) : SNPs within 2kb(218 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR025661	Cysteine peptidase, asparagine active site
InterPro	IPR000169	Cysteine peptidase, cysteine active site
InterPro	IPR025660	Cysteine peptidase, histidine active site
InterPro	IPR013128	Peptidase C1A, papain
InterPro	IPR000668	Peptidase C1A, papain C-terminal
InterPro	IPR013201	Proteinase inhibitor I29, cathepsin propeptide
Protein Ontology	PR:000006029	cathepsin H

References

(Earliest) J:12285 Wang X, et al., Chromosome assignment of cathepsin B CTSB to 8p22 and cathepsin H (CTSH) to 15q24-q25. Cytogenet Cell Genet. 1987;46:710-711
(Latest) J:212278 Floyel T, et al., CTSH regulates beta-cell function and disease progression in newly diagnosed type 1 diabetes patients. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10305-10
All references(51)

Other
accession IDs

MGD-MRK-35750, MGI:2143173