Ctsh MGI Mouse Gene Detail - MGI:107285

Symbol

Ctsh
Name

cathepsin H
Synonyms

Cat H

Feature Type

protein coding gene
IDs

MGI:107285
NCBI Gene: 13036
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr9:89936320-89958148 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 47.40 cM
Mapping Data

8 experiments

SNPs within 2kb

217 from dbSNP Build 142
Strain Annotations

17
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107285	protein coding gene	Chr9:89936205-89958148 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035119	protein coding gene	Chr9:90980430-91008898 (+)
A/J	MGP_AJ_G0035100	protein coding gene	Chr9:87844162-87866766 (+)
AKR/J	MGP_AKRJ_G0035032	protein coding gene	Chr9:89907339-89929015 (+)
BALB/cJ	MGP_BALBcJ_G0035092	protein coding gene	Chr9:87494580-87517150 (+)
C3H/HeJ	MGP_C3HHeJ_G0034803	protein coding gene	Chr9:90357611-90381434 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035613	protein coding gene	Chr9:93523495-93544965 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032516	protein coding gene	Chr9:86026506-86047254 (+)
CAST/EiJ	MGP_CASTEiJ_G0034115	protein coding gene	Chr9:90135296-90157605 (+)
CBA/J	MGP_CBAJ_G0034771	protein coding gene	Chr9:96763158-96789592 (+)
DBA/2J	MGP_DBA2J_G0034933	protein coding gene	Chr9:87389057-87411639 (+)
FVB/NJ	MGP_FVBNJ_G0034879	protein coding gene	Chr9:86415939-86437548 (+)
LP/J	MGP_LPJ_G0035012	protein coding gene	Chr9:91210420-91233720 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034920	protein coding gene	Chr9:98374764-98415250 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035633	protein coding gene	Chr9:90128553-90152222 (+)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0033656	protein coding gene	Chr9:90209075-90230357 (+)
WSB/EiJ	MGP_WSBEiJ_G0034235	protein coding gene	Chr9:90015335-90039640 (+)

Human Ortholog

CTSH, cathepsin H

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CTSH, cathepsin H
Synonyms

ACC4, ACC-4, ACC5, ACC-5, CPSB
Links

HGNC:2535

NCBI Gene ID: 1512

neXtProt AC: NX_P09668

UniProt: P09668
Chr Location

15q25.1; chr15:78921750-78945098 (-) GRCh38.p7

Alliance of Genome Resources

Ctsh stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CTSH
Gene Tree

Ctsh

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Phenotype Summary

10 phenotypes from 2 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

4
Genomic Mutations

1 involving Ctsh
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a reporter allele exhibit impaired lung surfactant and an abnormal eye globe with elongated axial length.

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All GO Annotations

59
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

786
Tissues

51
cDNA Data

204
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ctsh

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Ctsh interacts with 172 markers (Mir15a, Mir16-1, Mir19a, ...) View All

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All Sequences

65
RefSeq

6
UniProt

6
CCDS

CCDS23399.1

Ensembl

ENSMUSG00000032359 (Evidence)
NCBI Gene

13036

			Length	Strain/Species	Flank
genomic	13036	NCBI Gene Model \| MGI Sequence Detail	21829	C57BL/6J	± kb
transcript	NM_007801	RefSeq \| MGI Sequence Detail	1630	C57BL/6
polypeptide	P49935	UniProt \| EBI \| MGI Sequence Detail	333	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000006029 cathepsin H

(term hierarchy)
EC

3.4.22.16
InterPro Domains

IPR013201 Cathepsin propeptide inhibitor domain (I29)

IPR025661 Cysteine peptidase, asparagine active site

IPR000169 Cysteine peptidase, cysteine active site

IPR025660 Cysteine peptidase, histidine active site

IPR039417 Papain-like cysteine endopeptidase

IPR038765 Papain-like cysteine peptidase superfamily

IPR000668 Peptidase C1A, papain C-terminal

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All nucleic 206

cDNA 204

Primer pair 1

Other 1

Microarray probesets 4

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MGD-MRK-35750, MGI:2143173

Summaries

All 60

Developmental Gene Expression 9

Gene Ontology 8

Phenotypes 15
Earliest

J:12285 Wang X, et al., Chromosome assignment of cathepsin B CTSB to 8p22 and cathepsin H (CTSH) to 15q24-q25. Cytogenet Cell Genet. 1987;46:710-711
Latest

J:238995 Yan D, et al., STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1alpha Activation. Cell Rep. 2016 Sep 13;16(11):2914-27

TSS for Ctsh:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86446	Chr9:89936299-89936312 (+)	-14 bp
Tssr86447	Chr9:89936398-89936432 (+)	95 bp
Tssr86448	Chr9:89936440-89936476 (+)	138 bp
Tssr86449	Chr9:89936508-89936511 (+)	190 bp
Tssr2968	Chr9:89936525-89936536 (+)	211 bp
Tssr86450	Chr9:89936540-89936552 (+)	226 bp
Tssr86451	Chr9:89936560-89936578 (+)	249 bp
Tssr86452	Chr9:89936582-89936598 (+)	270 bp
Tssr86453	Chr9:89936633-89936643 (+)	318 bp
Tssr86454	Chr9:89936651-89936659 (+)	335 bp
Tssr86455	Chr9:89937333-89937364 (+)	1,029 bp
Tssr86456	Chr9:89946560-89946602 (+)	10,261 bp
Tssr86457	Chr9:89949804-89949840 (+)	13,502 bp
Tssr86458	Chr9:89955976-89955987 (+)	19,662 bp
Tssr86459	Chr9:89956134-89956145 (+)	19,820 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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