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Ctsh
Gene Detail
 Symbol
Name
ID
Ctsh
cathepsin H
MGI:107285
Synonyms Cat H
Feature Type protein coding gene
Genetic Map
Chromosome 9
47.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr9:90054152-90076089 bp, + strand
From VEGA annotation of GRCm38

  21938 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36159  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ctsh

Human
homologs
Human Homolog CTSH, cathepsin H
NCBI Gene ID 1512
neXtProt AC  NX_P09668
Human Synonyms  ACC-4, ACC-5, CPSB, minichain
Human Chr (Location)  15q25.1; chr15:78921750-78945094 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter allele exhibit impaired lung surfactant and an abnormal eye globe with elongated axial length.
 
Interactions
Ctsh interacts with 173 markers (Mir15a, Mir16-1, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component acrosomal vesicle, alveolar lamellar body, ...
Function aminopeptidase activity, cysteine-type endopeptidase activator activity involved in apoptotic process, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (30)    Tissues (19)    Images (3)
Theiler Stages: 23, 27, 28
Assay TypeResults
RNA in situ 26
RT-PCR 4
cDNA source data(202)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(204) cDNA(202) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024409 (Evidence)
Ensembl Gene ModelENSMUSG00000032359 (Evidence)
Entrez Gene13036 (Evidence)
UniGene2277
DFCITC1572082, TC1622684
DoTSDT.101184564, DT.101257872, DT.110642551, DT.494631, DT.99864755
NIA Mouse Gene IndexU010845
EC3.4.22.16
Consensus CDS ProjectCCDS23399.1
International Mouse Knockout Project StatusCtsh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024409 VEGA Gene Model | MGI Sequence Detail 21938 C57BL/6J ±  kb
transcript OTTMUST00000059829 VEGA | MGI Sequence Detail 1617 Not Applicable 
polypeptide OTTMUSP00000029135 VEGA | MGI Sequence Detail 333 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(2) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(218 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025661 Cysteine peptidase, asparagine active site
InterPro IPR000169 Cysteine peptidase, cysteine active site
InterPro IPR025660 Cysteine peptidase, histidine active site
InterPro IPR013128 Peptidase C1A, papain
InterPro IPR000668 Peptidase C1A, papain C-terminal
InterPro IPR013201 Proteinase inhibitor I29, cathepsin propeptide
Protein Ontology PR:000006029 cathepsin H
References (Earliest) J:12285 Wang X, et al., Chromosome assignment of cathepsin B CTSB to 8p22 and cathepsin H (CTSH) to 15q24-q25. Cytogenet Cell Genet. 1987;46:710-711
(Latest) J:206689 Aldahmesh MA, et al., Mutations in LRPAP1 are associated with severe myopia in humans. Am J Hum Genet. 2013 Aug 8;93(2):313-20
All references(49)
Other
accession IDs
MGD-MRK-35750, MGI:2143173

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory