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Ctsh Gene Detail
Summary
  • Symbol
    Ctsh
  • Name
    cathepsin H
  • Synonyms
    Cat H
  • Feature Type
    protein coding gene
  • IDs
    MGI:107285
    NCBI Gene: 13036
  • Gene Overview
    MyGene.info: CTSH
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr9:90054152-90076089 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      21938 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 47.40 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    CTSH, cathepsin H
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CTSH, cathepsin H
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACC4, ACC-4, ACC5, ACC-5, CPSB
  • Links
    NCBI Gene ID: 1512
    neXtProt AC: NX_P09668
    UniProt: P09668

  • Chr Location
    15q25.1; chr15:78921750-78945098 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele exhibit impaired lung surfactant and an abnormal eye globe with elongated axial length.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    30
  • Tissues
    19
  • cDNA Data
    202
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000024409 VEGA Gene Model | MGI Sequence Detail 21938 C57BL/6J ±  kb
    transcript OTTMUST00000059829 VEGA | MGI Sequence Detail 1617 Not Applicable  
    polypeptide OTTMUSP00000029135 VEGA | MGI Sequence Detail 333 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      217 from dbSNP Build 142
    • RFLP
      1
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 204
      cDNA 202
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35750, MGI:2143173
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:12285 Wang X, et al., Chromosome assignment of cathepsin B CTSB to 8p22 and cathepsin H (CTSH) to 15q24-q25. Cytogenet Cell Genet. 1987;46:710-711
    • Latest
      J:238995 Yan D, et al., STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1alpha Activation. Cell Rep. 2016 Sep 13;16(11):2914-27
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory