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Ctsh
Gene Detail
Symbol

Name
ID
Ctsh
cathepsin H
MGI:107285
Synonyms
Cat H
Feature Type
protein coding gene
Genetic Map
Chromosome 9
47.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr9:90054152-90076089 bp, + strand
From VEGA annotation of GRCm38

  21938 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36159  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: CTSH
Gene Tree: Ctsh

Human
homologs
CTSH, cathepsin H
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1512
neXtProt AC: NX_P09668

Human Synonyms: ACC4, ACC-4, ACC5, ACC-5, CPSB, minichain

Human Chr (Location): 15q25.1; chr15:78921750-78945089 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter allele exhibit impaired lung surfactant and an abnormal eye globe with elongated axial length.
 
Interactions
Ctsh interacts with 172 markers (Mir15a, Mir16-1, Mir19a, ...)
Expression
Literature Summary: (7 records)
Data Summary: Results (30)    Tissues (19)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 26
RT-PCR 4
cDNA source data(202)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ctsh    NEW 
Molecular
reagents
All nucleic(204) cDNA(202) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000024409 (Evidence)
Ensembl Gene Model ENSMUSG00000032359 (Evidence)
Entrez Gene 13036 (Evidence)
UniGene 2277
DFCI TC1622684, TC1572082
DoTS DT.101184564, DT.494631, DT.110642551, DT.101257872, DT.99864755
NIA Mouse Gene Index U010845
EC 3.4.22.16
Consensus CDS Project CCDS23399.1
International Mouse Phenotyping Consortium Status Ctsh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024409 VEGA Gene Model | MGI Sequence Detail 21938 C57BL/6J ±  kb
transcript OTTMUST00000059829 VEGA | MGI Sequence Detail 1617 Not Applicable 
polypeptide OTTMUSP00000029135 VEGA | MGI Sequence Detail 333 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(5) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(218 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025661 Cysteine peptidase, asparagine active site
InterPro IPR000169 Cysteine peptidase, cysteine active site
InterPro IPR025660 Cysteine peptidase, histidine active site
InterPro IPR013128 Peptidase C1A, papain
InterPro IPR000668 Peptidase C1A, papain C-terminal
InterPro IPR013201 Proteinase inhibitor I29, cathepsin propeptide
Protein Ontology PR:000006029 cathepsin H
References
(Earliest) J:12285 Wang X, et al., Chromosome assignment of cathepsin B CTSB to 8p22 and cathepsin H (CTSH) to 15q24-q25. Cytogenet Cell Genet. 1987;46:710-711
(Latest) J:212278 Floyel T, et al., CTSH regulates beta-cell function and disease progression in newly diagnosed type 1 diabetes patients. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10305-10
All references(52)
Other
accession IDs
MGD-MRK-35750, MGI:2143173

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory