Ctsh MGI Mouse Gene Detail - MGI:107285

Ctsh Gene Detail

Symbol

Ctsh
Name

cathepsin H
Synonyms

Cat H

Feature Type

protein coding gene
IDs

MGI:107285
NCBI Gene: 13036
Gene Overview

MyGene.info: CTSH
Alliance

gene page

Sequence Map

Chr9:90054152-90076089 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

21938 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 47.40 cM
Mapping Data

8 experiments

Human Ortholog

CTSH, cathepsin H

Vertebrate Orthologs

9

Human Ortholog

CTSH, cathepsin H
Orthology source: HGNC, HomoloGene
Synonyms

ACC4, ACC-4, ACC5, ACC-5, CPSB
Links

HGNC:2535

NCBI Gene ID: 1512

neXtProt AC: NX_P09668

UniProt: P09668
Chr Location

15q25.1; chr15:78921750-78945098 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 36159
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: CTSH
Gene Tree

Ctsh

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Phenotype Summary

5 phenotypes from 1 allele in 2 genetic backgrounds
1 phenotype from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Targeted

4
Genomic Mutations

1 involving Ctsh
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a reporter allele exhibit impaired lung surfactant and an abnormal eye globe with elongated axial length.

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All GO Annotations

59
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

30
Tissues

19
cDNA Data

203
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ctsh

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Ctsh interacts with 172 markers (Mir15a, Mir16-1, Mir19a, ...) View All

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All Sequences

65
RefSeq

6
UniProt

6
CCDS

CCDS23399.1
UniGene

2277

			Length	Strain/Species	Flank
genomic	OTTMUSG00000024409	VEGA Gene Model \| MGI Sequence Detail	21938	C57BL/6J	± kb
transcript	OTTMUST00000059829	VEGA \| MGI Sequence Detail	1617	Not Applicable
polypeptide	OTTMUSP00000029135	VEGA \| MGI Sequence Detail	333	Not Applicable

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SNPs within 2kb

217 from dbSNP Build 142

RFLP

1

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UniProt

6 Sequences
Protein Ontology

PR:000006029 cathepsin H

(term hierarchy)
EC

3.4.22.16
InterPro Domains

IPR013201 Cathepsin propeptide inhibitor domain (I29)

IPR025661 Cysteine peptidase, asparagine active site

IPR000169 Cysteine peptidase, cysteine active site

IPR025660 Cysteine peptidase, histidine active site

IPR038765 Papain-like cysteine peptidase superfamily

IPR013128 Peptidase C1A

IPR000668 Peptidase C1A, papain C-terminal

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All nucleic 205

cDNA 203

Primer pair 1

Other 1

Microarray probesets 4

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MGD-MRK-35750, MGI:2143173

Summaries

All 56

Developmental Gene Expression 7

Gene Ontology 8

Phenotypes 12
Earliest

J:12285 Wang X, et al., Chromosome assignment of cathepsin B CTSB to 8p22 and cathepsin H (CTSH) to 15q24-q25. Cytogenet Cell Genet. 1987;46:710-711
Latest

J:238995 Yan D, et al., STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1alpha Activation. Cell Rep. 2016 Sep 13;16(11):2914-27

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/11/2018 MGI 6.12