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Rab6b Gene Detail
Summary
  • Symbol
    Rab6b
  • Name
    RAB6B, member RAS oncogene family
  • Synonyms
    C330006L04Rik, D9Bwg0185e
  • Feature Type
    protein coding gene
  • IDs
    MGI:107283
    NCBI Gene: 270192
  • Gene Overview
    MyGene.info: RAB6B
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:103112074-103185276 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 54.88 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    499 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107283
protein coding gene Chr9:103111787-103185276 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035193
protein coding gene Chr9:104714398-104791669 (+)
A/J MGP_AJ_G0035173
protein coding gene Chr9:100945163-101022419 (+)
AKR/J MGP_AKRJ_G0035105
protein coding gene Chr9:103443227-103520871 (+)
BALB/cJ MGP_BALBcJ_G0035166
protein coding gene Chr9:100661168-100735818 (+)
C3H/HeJ MGP_C3HHeJ_G0034876
protein coding gene Chr9:103838044-103912529 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035686
protein coding gene Chr9:107628334-107703791 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032585
protein coding gene Chr9:98532513-98604782 (+)
CAST/EiJ MGP_CASTEiJ_G0034188
protein coding gene Chr9:103679934-103758731 (+)
CBA/J MGP_CBAJ_G0034845
protein coding gene Chr9:111384784-111464880 (+)
DBA/2J MGP_DBA2J_G0035006
protein coding gene Chr9:100439888-100513098 (+)
FVB/NJ MGP_FVBNJ_G0034954
protein coding gene Chr9:99239137-99315361 (+)
LP/J MGP_LPJ_G0035082
protein coding gene Chr9:104920907-104998131 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034993
protein coding gene Chr9:113193397-113268713 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035708
protein coding gene Chr9:103688304-103771228 (+)
PWK/PhJ MGP_PWKPhJ_G0033895
protein coding gene Chr9:100695751-100771209 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033730
protein coding gene Chr9:103741018-103819977 (+)
WSB/EiJ MGP_WSBEiJ_G0034308
protein coding gene Chr9:103578350-103657069 (+)



Homology
more
  • Human Ortholog
    RAB6B, RAB6B, member RAS oncogene family
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RAB6B, RAB6B, member RAS oncogene family
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 51560
    neXtProt AC: NX_Q9NRW1
    UniProt: Q9NRW1

  • Chr Location
    3q22.1; chr3:133824235-133895847 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in growth retardation and multiple behavioral and immunological abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 270192 NCBI Gene Model | MGI Sequence Detail 73203 C57BL/6J ±  kb
    transcript NM_173781 RefSeq | MGI Sequence Detail 4734 C57BL/6  
    polypeptide P61294 UniProt | EBI | MGI Sequence Detail 208 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-35748, MGI:1924738, MGI:2143137
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory