Rab6b
Gene Detail

Symbol Name ID

Rab6b RAB6B, member RAS oncogene family MGI:107283

Synonyms

C330006L04Rik, D9Bwg0185e

Feature Type

protein coding gene

Genetic Map

Chromosome 9

54.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:103112074-103185270 bp, + strand From NCBI annotation of GRCm38   73197 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Rab6b ± 2 cM)

Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab6b

Human ortholog

RAB6B RAB6B, member RAS oncogene family NCBI Gene ID 51560
Human Chr3:133543079-133614691 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(8) : Gene trapped(8)
 

Homozygous mutation of this gene results in growth retardation and multiple behavioral and immunological abnormalities.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	protein transport, small GTPase mediated signal transduction, ...
Component	cytoplasmic vesicle, Golgi apparatus, ...
Function	GTP binding, nucleotide binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (105)    Tissues (27)    Images (23)
Theiler Stages: 17, 21, 23, 24, 26, 28

Assay Type	Results
RNA in situ	93
Western blot	12

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(8)

Other database links

Ensembl Gene Model	ENSMUSG00000032549 (Evidence)
Entrez Gene	270192 (Evidence)
DFCI	TC1575875, TC1621027
DoTS	DT.488158
NIA Mouse Gene Index	U010941
Consensus CDS Project	CCDS23449.1
International Mouse Knockout Project Status	Rab6b

Sequences

Length	Strain/Species
genomic	270192	NCBI Gene Model | MGI Sequence Detail	73197	C57BL/6J
transcript	NM_173781	RefSeq | MGI Sequence Detail	4734	C57BL/6
polypeptide	P61294	UniProt | EBI | MGI Sequence Detail	208	Not Applicable

All sequences(25) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(221 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001806	Small GTPase superfamily
InterPro	IPR003579	Small GTPase superfamily, Rab type
InterPro	IPR005225	Small GTP-binding protein domain
Protein Ontology	PR:000013637	ras-related protein Rab-6B

Graphical View of Protein Domain Structure

References

(Earliest) J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(33)

Other accession IDs

MGD-MRK-35748, MGI:1924738, MGI:2143137