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Nsun2
Gene Detail
 Symbol
Name
ID
Nsun2
NOL1/NOP2/Sun domain family member 2
MGI:107252
Synonyms Misu
Feature Type protein coding gene
Genetic Map
Chromosome 13
35.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr13:69533746-69635780 bp, + strand
From VEGA annotation of GRCm38

  102035 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9817  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nsun2

Human
homologs
Human Homolog NSUN2, NOP2/Sun RNA methyltransferase family, member 2
NCBI Gene ID 54888
neXtProt AC  NX_Q08J23
Human Synonyms  MISU, MRT5, SAKI, TRM4
Human Chr (Location)  5p15.31; chr5:6599239-6633360 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NSUN2
Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(23) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to decreased body size, male sterility, and hair cycle anomalies. Additional phenotypes may include reduced body fat, skeletal, craniofacial and eye defects, abnormal erythropoiesis, and altered energy expenditure and gas, glucose, and lipid homeostasis.
 
Interactions
Nsun2 interacts with 221 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, cytoskeleton, ...
Function methyltransferase activity, poly(A) RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (6)    Tissues (2)   
Theiler Stages: 11
Assay TypeResults
RT-PCR 6
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000024575 (Evidence)
Ensembl Gene ModelENSMUSG00000021595 (Evidence)
Entrez Gene28114 (Evidence)
DFCITC1571928, TC1589517, TC1752241, TC1771740
DoTSDT.101385685, DT.101385688, DT.102539866, DT.110974826, DT.523501, DT.535422, DT.55271777
NIA Mouse Gene IndexU014977
EC2.1.1.203
Consensus CDS ProjectCCDS36722.2
International Mouse Knockout Project StatusNsun2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024575 VEGA Gene Model | MGI Sequence Detail 102035 C57BL/6J ±  kb
transcript OTTMUST00000060366 VEGA | MGI Sequence Detail 2834 Not Applicable 
polypeptide OTTMUSP00000043252 VEGA | MGI Sequence Detail 757 Not Applicable 

For the selected sequences
All sequences(86) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(995 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001678 Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p
InterPro IPR023267 RNA (C5-cytosine) methyltransferase
InterPro IPR023270 tRNA (C5-cytosine) methyltransferase, NCL1
Protein Ontology PR:000011450 tRNA (cytosine(34)-C(5))-methyltransferase
References (Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:203322 Hussain S, et al., The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation. Mol Cell Biol. 2013 Apr;33(8):1561-70
All references(38)
Other
accession IDs
MGD-MRK-35717

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory