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Adam7 Gene Detail
Summary
  • Symbol
    Adam7
  • Name
    a disintegrin and metallopeptidase domain 7
  • Synonyms
    EAP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107247
    NCBI Gene: 11500
Location & Maps
more
  • Sequence Map
    Chr14:68497336-68533689 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      36354 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 35.69 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ADAM7, ADAM metallopeptidase domain 7
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ADAM7, ADAM metallopeptidase domain 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADAM 7, ADAM-7, EAPI, GP83, GP-83
  • Links
    NCBI Gene ID: 8756
    neXtProt AC: NX_Q9H2U9

  • Chr Location
    8p21.2; chr8:24440996-24512760 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    2
  • Chemically induced (other)
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Adam7
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025841 VEGA Gene Model | MGI Sequence Detail 36354 C57BL/6J ±  kb
transcript OTTMUST00000063665 VEGA | MGI Sequence Detail 3469 Not Applicable  
polypeptide OTTMUSP00000031509 VEGA | MGI Sequence Detail 789 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    443 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000003724 disintegrin and metalloproteinase domain-containing protein 7
  • InterPro Domains
    IPR006586 ADAM, cysteine-rich
    IPR018358 Disintegrin, conserved site
    IPR001762 Disintegrin domain
    IPR024079 Metallopeptidase, catalytic domain
    IPR001590 Peptidase M12B, ADAM/reprolysin
    IPR002870 Peptidase M12B, propeptide
Molecular
Reagents
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  • All nucleic 8
    Genomic 1
    cDNA 6
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-35712
References
more
  • Summaries
    All 30
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:17855 Ballock RT, et al., Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta. J Cell Physiol. 1994 May;159(2):340-6
  • Latest
    J:226260 Choi H, et al., Reduced Fertility and Altered Epididymal and Sperm Integrity in Mice Lacking ADAM7. Biol Reprod. 2015 Sep;93(3):70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory