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Adam7 Gene Detail
Summary
  • Symbol
    Adam7
  • Name
    a disintegrin and metallopeptidase domain 7
  • Synonyms
    EAP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107247
    NCBI Gene: 11500
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:68497336-68533689 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 35.69 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    443 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107247
protein coding gene Chr14:68497336-68533741 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021510
protein coding gene Chr14:63272227-63309962 (-)
A/J MGP_AJ_G0021469
protein coding gene Chr14:61749712-61785932 (-)
AKR/J MGP_AKRJ_G0021445
protein coding gene Chr14:63836252-63872028 (-)
BALB/cJ MGP_BALBcJ_G0021475
protein coding gene Chr14:61733815-61774049 (-)
C3H/HeJ MGP_C3HHeJ_G0021252
protein coding gene Chr14:63581497-63619425 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021914
protein coding gene Chr14:66132043-66173642 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019454
protein coding gene Chr14:59633452-59670603 (-)
CAST/EiJ MGP_CASTEiJ_G0020769
protein coding gene Chr14:60088029-60129185 (-)
CBA/J MGP_CBAJ_G0021219
protein coding gene Chr14:68159362-68197474 (-)
DBA/2J MGP_DBA2J_G0021342
protein coding gene Chr14:61363573-61403592 (-)
FVB/NJ MGP_FVBNJ_G0021321
protein coding gene Chr14:60772420-60807916 (-)
LP/J MGP_LPJ_G0021417
protein coding gene Chr14:64328217-64370593 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021350
protein coding gene Chr14:67122957-67164270 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021937
protein coding gene Chr14:63075482-63117620 (-)
PWK/PhJ MGP_PWKPhJ_G0020513
protein coding gene Chr14:58129971-58166925 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020346
protein coding gene Chr14:59012289-59050844 (-)
WSB/EiJ MGP_WSBEiJ_G0020822
protein coding gene Chr14:63397767-63435021 (-)



Homology
more
  • Human Ortholog
    ADAM7, ADAM metallopeptidase domain 7
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ADAM7, ADAM metallopeptidase domain 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADAM 7, ADAM-7, EAPI, GP83, GP-83
  • Links
    NCBI Gene ID: 8756
    neXtProt AC: NX_Q9H2U9
    UniProt: Q9H2U9

  • Chr Location
    8p21.2; chr8:24440996-24509565 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced male fertility with decreased cell height in caput epididymis, spermatic granuloma, kinked sperm flagellum and reduced sperm motility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11500 NCBI Gene Model | MGI Sequence Detail 36354 C57BL/6J ±  kb
transcript NM_007402 RefSeq | MGI Sequence Detail 3469 C57BL/6  
polypeptide O35227 UniProt | EBI | MGI Sequence Detail 789 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    Genomic 2
    cDNA 5

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35712
References
more
  • Summaries
    All 30
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:17855 Ballock RT, et al., Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta. J Cell Physiol. 1994 May;159(2):340-6
  • Latest
    J:226260 Choi H, et al., Reduced Fertility and Altered Epididymal and Sperm Integrity in Mice Lacking ADAM7. Biol Reprod. 2015 Sep;93(3):70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory