About   Help   FAQ
Tinf2 Gene Detail
Summary
  • Symbol
    Tinf2
  • Name
    Terf1 (TRF1)-interacting nuclear factor 2
  • Synonyms
    D14Wsu146e, TIN2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107246
    NCBI Gene: 28113
  • Gene Overview
    MyGene.info: TINF2
Location & Maps
more
  • Sequence Map
    Chr14:55679083-55681817 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2735 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TINF2, TERF1 interacting nuclear factor 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TINF2, TERF1 interacting nuclear factor 2
    Orthology source: HomoloGene
  • Synonyms
    DKCA3, TIN2
  • Links
    NCBI Gene ID: 26277
    neXtProt AC: NX_Q9BSI4

  • Chr Location
    14q12; chr14:24234403-24243027 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Tinf2 mouse models; 3 with human TINF2 associations

Human Disease Mouse Models
       Dyskeratosis Congenita, Autosomal Dominant 3; DKCA3   OMIM: 613990 View 1 model
       Dyskeratosis Congenita, Autosomal Dominant 1; DKCA1   OMIM: 127550
Revesz Syndrome   OMIM: 268130
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    8
  • Genomic Mutations
    1 involving Tinf2
  • Incidental Mutations
Targeted disruption of this gene results in embryonic lethality prior to E7.5 through a mechanism that is independent of telomerase function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000007589 Ensembl Gene Model | MGI Sequence Detail 2735 C57BL/6J ±  kb
transcript ENSMUST00000007733 Ensembl | MGI Sequence Detail 1736 Not Applicable  
polypeptide ENSMUSP00000007733 Ensembl | MGI Sequence Detail 414 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    39 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000016358 TERF1-interacting nuclear factor 2
  • InterPro Domains
    IPR029400 TERF1-interacting nuclear factor 2, N-terminal domain
Molecular
Reagents
less
  • All nucleic 100
    cDNA 99
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-35711, MGI:2145835
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:230610 Hartmann K, et al., Gene dosage reductions of Trf1 and/or Tin2 induce telomere DNA damage and lymphoma formation in aging mice. Leukemia. 2016 Mar;30(3):749-53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory