Tinf2
Gene Detail

Symbol Name ID

Tinf2 Terf1 (TRF1)-interacting nuclear factor 2 MGI:107246

Synonyms

D14Wsu146e, TIN2

Feature Type

protein coding gene

Genetic Map

Chromosome 14

28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr14:55679083-55681817 bp, - strand From Ensembl annotation of GRCm38   2735 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8264  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: TERF1-interacting nuclear factor 2 (TINF2)
Gene Tree: Tinf2

Human homologs

Human Homolog		TINF2, TERF1 (TRF1)-interacting nuclear factor 2
NCBI Gene ID		26277
neXtProt AC		NX_Q9BSI4
Human Synonyms		DKCA3, TIN2
Human Chr (Location)		14q12; chr14:24708849-24711880 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human TINF2

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Targeted disruption of this gene results in embryonic lethality prior to E7.5 through a mechanism that is independent of telomerase function.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	negative regulation of epithelial cell proliferation, negative regulation of protein ADP-ribosylation, ...
Component	chromosome, chromosome, telomeric region, ...
Function	protein binding, telomeric DNA binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (77)    Tissues (10)    Images (21)
Theiler Stages: 11, 23

Assay Type	Results
RNA in situ	71
RT-PCR	6

cDNA source data(88)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(89) cDNA(88) Primer pair(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000007589 (Evidence)
Entrez Gene	28113 (Evidence)
UniGene	29346
NIA Mouse Gene Index	U035585
Consensus CDS Project	CCDS27125.1
International Mouse Knockout Project Status	Tinf2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000007589	Ensembl Gene Model | MGI Sequence Detail	2735	C57BL/6J
transcript	ENSMUST00000007733	Ensembl | MGI Sequence Detail	1736	Not Applicable
polypeptide	ENSMUSP00000007733	Ensembl | MGI Sequence Detail	414	Not Applicable

All sequences(37) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(32 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000016358	TERF1-interacting nuclear factor 2

References

(Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:178606 Takai KK, et al., Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. Mol Cell. 2011 Nov 18;44(4):647-59
All references(33)

Other accession IDs

MGD-MRK-35711, MGI:2145835