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Tinf2
Gene Detail
 Symbol
Name
ID
Tinf2
Terf1 (TRF1)-interacting nuclear factor 2
MGI:107246
Synonyms D14Wsu146e, TIN2
Feature Type protein coding gene
Genetic Map
Chromosome 14
28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr14:55679083-55681817 bp, - strand
From Ensembl annotation of GRCm38

  2735 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8264  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: TERF1-interacting nuclear factor 2 (TINF2)
Gene Tree: Tinf2

Human
homologs
Human Homolog TINF2, TERF1 (TRF1)-interacting nuclear factor 2
NCBI Gene ID 26277
neXtProt AC  NX_Q9BSI4
Human Synonyms  DKCA3, TIN2
Human Chr (Location)  14q12; chr14:24234248-24243027 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human TINF2
Alleles
and
phenotypes
All alleles(9) : Gene trapped(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted disruption of this gene results in embryonic lethality prior to E7.5 through a mechanism that is independent of telomerase function.
 
Human Diseases Modeled Using Mouse Tinf2 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process negative regulation of epithelial cell proliferation, negative regulation of protein ADP-ribosylation, ...
Component chromosome, chromosome, telomeric region, ...
Function protein binding, telomeric DNA binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (77)    Tissues (10)    Images (21)
Theiler Stages: 11, 23
Assay TypeResults
RNA in situ 71
RT-PCR 6
cDNA source data(99)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(100) cDNA(99) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000007589 (Evidence)
Entrez Gene28113 (Evidence)
UniGene29346
NIA Mouse Gene IndexU035585
Consensus CDS ProjectCCDS27125.1
International Mouse Knockout Project StatusTinf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000007589 Ensembl Gene Model | MGI Sequence Detail 2735 C57BL/6J ±  kb
transcript ENSMUST00000007733 Ensembl | MGI Sequence Detail 1736 Not Applicable 
polypeptide ENSMUSP00000007733 Ensembl | MGI Sequence Detail 414 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(5)
Polymorphisms SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000016358 TERF1-interacting nuclear factor 2
References (Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:207367 Frescas D, et al., A TIN2 dyskeratosis congenita mutation causes telomerase-independent telomere shortening in mice. Genes Dev. 2014 Jan 15;28(2):153-66
All references(35)
Other
accession IDs
MGD-MRK-35711, MGI:2145835

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory