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Tinf2
Gene Detail
Symbol

Name
ID
Tinf2
Terf1 (TRF1)-interacting nuclear factor 2
MGI:107246
Synonyms
D14Wsu146e, TIN2
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr14:55679083-55681817 bp, - strand
From Ensembl annotation of GRCm38

  2735 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:8264  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: TINF2
Protein SuperFamily: TERF1-interacting nuclear factor 2 (TINF2)
Gene Tree: Tinf2

Human
homologs
TINF2, TERF1 (TRF1)-interacting nuclear factor 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 26277
neXtProt AC: NX_Q9BSI4

Human Synonyms: DKCA3, TIN2

Human Chr (Location): 14q12; chr14:24234403-24243027 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human TINF2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted disruption of this gene results in embryonic lethality prior to E7.5 through a mechanism that is independent of telomerase function.
 
Human Diseases Modeled in Mice Using Tinf2 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Tinf2 interacts with 55 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (77)    Tissues (10)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 71
RT-PCR 6
cDNA source data(99)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tinf2    NEW 
Molecular
reagents
All nucleic(100) cDNA(99) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000007589 (Evidence)
Entrez Gene 28113 (Evidence)
UniGene 29346
NIA Mouse Gene Index U035585
Consensus CDS Project CCDS27125.1
International Mouse Phenotyping Consortium Status Tinf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000007589 Ensembl Gene Model | MGI Sequence Detail 2735 C57BL/6J ±  kb
transcript ENSMUST00000007733 Ensembl | MGI Sequence Detail 1736 Not Applicable 
polypeptide ENSMUSP00000007733 Ensembl | MGI Sequence Detail 414 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR029400 TERF1-interacting nuclear factor 2, N-terminal domain
Protein Ontology PR:000016358 TERF1-interacting nuclear factor 2
References
(Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:217428 Zimmermann M, et al., TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling. Genes Dev. 2014 Nov 15;28(22):2477-91
All references(36)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-35711, MGI:2145835

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory