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Gtf2h5
Gene Detail
 Symbol
Name
ID
Gtf2h5
general transcription factor IIH, polypeptide 5
MGI:107227
Synonyms 2700017P07Rik, 2810432H05Rik, D17Wsu155e
Feature Type protein coding gene
Genetic Map
Chromosome 17
3.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:6079786-6086517 bp, + strand
From VEGA annotation of GRCm38

  6732 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:45635  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gtf2h5

Human
homologs
Human Homolog GTF2H5, general transcription factor IIH, polypeptide 5
NCBI Gene ID 404672
neXtProt AC  NX_Q6ZYL4
Human Synonyms  bA120J8.2, C6orf175, TFB5, TFIIH, TGF2H5, TTD, TTDA, TTD-A
Human Chr (Location)  6q25.3; chr6:158168347-158199344 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GTF2H5
Alleles
and
phenotypes
All alleles(17) : Targeted(1) Gene trapped(16)
 
Mice homozygous for a knock-out allele exhibit complete postnatal lethality.
 
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cellular response to DNA damage stimulus, cellular response to gamma radiation, ...
Component core TFIIH complex, nucleolus, ...
Function rDNA binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (292)    Tissues (30)    Images (45)
Theiler Stages: 3, 11, 23
Assay TypeResults
RNA in situ 274
RT-PCR 18
cDNA source data(70)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(75) cDNA(71) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024049 (Evidence)
Ensembl Gene ModelENSMUSG00000034345 (Evidence)
Entrez Gene66467 (Evidence)
UniGene303441
DFCITC1576253, TC1621811
DoTSDT.101715961, DT.55100842
NIA Mouse Gene IndexU037366
Consensus CDS ProjectCCDS37423.1
International Mouse Knockout Project StatusGtf2h5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024049 VEGA Gene Model | MGI Sequence Detail 6732 C57BL/6J ±  kb
transcript OTTMUST00000058798 VEGA | MGI Sequence Detail 2245 Not Applicable 
polypeptide OTTMUSP00000028538 VEGA | MGI Sequence Detail 71 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009400 TFIIH subunit TTDA/Tfb5
Protein Ontology PR:000008321 general transcription factor IIH subunit 5
References (Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:200022 Theil AF, et al., Disruption of TTDA results in complete nucleotide excision repair deficiency and embryonic lethality. PLoS Genet. 2013 Apr;9(4):e1003431
All references(36)
Other
accession IDs
MGD-MRK-35692, MGI:1913717, MGI:1919816

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory