Shroom2 MGI Mouse Gene Detail - MGI:107194

Symbol

Shroom2
Name

shroom family member 2
Synonyms

Apxl, Shrm2

Feature Type

protein coding gene
IDs

MGI:107194
NCBI Gene: 110380
Alliance

genome feature page
Transcription Start Sites

14 TSS

Sequence Map

ChrX:151392505-151552461 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 68.46 cM, cytoband F2-F3
Mapping Data

4 experiments

SNPs within 2kb

3053 from dbSNP Build 142
Strain Annotations

19
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107194	protein coding gene	ChrX:151392505-151553784 (-)
129S1/SvImJ	ENSMUSG00200030169	protein coding gene	ChrX:128189405-128348086 (-)
A/J	ENSMUSG00195019909	protein coding gene	ChrX:133187490-133346182 (-)
AKR/J	ENSMUSG00220033580	protein coding gene	ChrX:125162058-125315385 (-)
BALB/cJ	ENSMUSG00180037050	protein coding gene	ChrX:128563253-128721947 (-)
C3H/HeJ	ENSMUSG00175026456	protein coding gene	ChrX:133131086-133291054 (-)
C57BL/6NJ	ENSMUSG00215025662	protein coding gene	ChrX:128884182-129044165 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033504	protein coding gene	ChrX:141268615-141439472 (-)
CAST/EiJ	ENSTCUG00005035191	protein coding gene	ChrX:130911435-131071926 (-)
CBA/J	ENSMUSG00210030881	protein coding gene	ChrX:130584913-130744888 (-)
DBA/2J	ENSMUSG00185043743	protein coding gene	ChrX:145406402-145566376 (-)
FVB/NJ	ENSMUSG00205023365	protein coding gene	ChrX:129102354-129261010 (-)
JF1/MsJ	ENSUMUG00000028783	protein coding gene	ChrX:165597374-165756112 (-)
LP/J	ENSMUSG00230013552	protein coding gene	ChrX:152198706-152357389 (-)
NOD/ShiLtJ	ENSMUSG00190028236	protein coding gene	ChrX:129624116-129782798 (-)
NZO/HlLtJ	ENSMUSG00225041344	protein coding gene	ChrX:155695698-155854377 (-)
PWK/PhJ	ENSLUMG00010031070	protein coding gene	ChrX:127112534-127273387 (-)
SPRET/EiJ	ENSMSPG00010039421	protein coding gene	ChrX:131984254-132149556 (-)
WSB/EiJ	ENSIUOG00005037349	protein coding gene	ChrX:130059779-130219624 (-)

Human Ortholog

SHROOM2, shroom family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SHROOM2, shroom family member 2
Synonyms

APXL, HSAPXL
Links

HGNC:630

NCBI Gene ID: 357

UniProt: Q13796
Chr Location

Xp22.2; chrX:9786429-9949443 (+) GRCh38

MGI Vertebrate Homology

Shroom2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SHROOM2
Gene Tree

Shroom2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Endonuclease-mediated

3
Gene trapped

22
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

45
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

648
Tissues

31
cDNA Data

13
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase shroom2

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All Sequences

72
RefSeq

24
UniProt

4
CCDS

CCDS41179.1, CCDS72455.1

Ensembl

ENSMUSG00000045180 (Evidence)
NCBI Gene

110380

			Length	Strain/Species	Flank
genomic	ENSMUSG00000045180	Ensembl Gene Model \| MGI Sequence Detail	159957	C57BL/6J	± kb
transcript	ENSMUST00000101141	Ensembl \| MGI Sequence Detail	7494	Not Applicable
polypeptide	ENSMUSP00000098701	Ensembl \| MGI Sequence Detail	1487	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014855 protein Shroom2

(term hierarchy)
InterPro Domains

IPR014800 Apx/Shrm Domain 1

IPR014799 Apx/Shrm Domain 2

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR027685 Shroom family
GlyGen

A2ALU4 5 sites, 2 N-linked glycans (3 sites)

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All nucleic 14

cDNA 13

Primer pair 1

Antibodies 1

Microarray probesets 3

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MGD-MRK-35655, MGI:2443591

Summaries

All 42

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 12
Earliest

J:33821 Dinulos MB, et al., A new region of conservation is defined between human and mouse X chromosomes. Genomics. 1996 Jul 1;35(1):244-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Shroom2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr164417	ChrX:151552668-151552682 (-)	-214 bp
Tssr164416	ChrX:151552596-151552645 (-)	-160 bp
Tssr164415	ChrX:151472456-151472464 (-)	80,001 bp
Tssr164414	ChrX:151440758-151440779 (-)	111,692 bp
Tssr164413	ChrX:151440499-151440505 (-)	111,959 bp
Tssr164412	ChrX:151440467-151440483 (-)	111,986 bp
Tssr164411	ChrX:151427484-151427540 (-)	124,949 bp
Tssr164410	ChrX:151427468-151427482 (-)	124,986 bp
Tssr164409	ChrX:151427427-151427466 (-)	125,014 bp
Tssr164408	ChrX:151427414-151427425 (-)	125,041 bp
Tssr164407	ChrX:151427130-151427158 (-)	125,317 bp
Tssr164406	ChrX:151427087-151427119 (-)	125,358 bp
Tssr164405	ChrX:151426860-151426877 (-)	125,592 bp
Tssr164404	ChrX:151426845-151426857 (-)	125,610 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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