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Ahsg
Gene Detail
Symbol

Name
ID
Ahsg
alpha-2-HS-glycoprotein
MGI:107189
Synonyms
fetuin-A
Feature Type
protein coding gene
Genetic Map
Chromosome 16
13.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:22892042-22899438 bp, + strand
From Ensembl annotation of GRCm38

  7397 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1225  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AHSG
Protein SuperFamily: alpha-2-HS-glycoprotein
Gene Tree: Ahsg

Human
homologs
AHSG, alpha-2-HS-glycoprotein
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 197
neXtProt AC: NX_P02765

Human Synonyms: A2HS, AHS, FETUA, HSGA

Human Chr (Location): 3q27; chr3:186613061-186621318 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice lacking this gene exhibit defective inhibition of serum apatite formation, sometimes causing muscle calcification. They are resistant to weight gain on a high-fat diet and have increased insulin sensitivity and glucose clearance and reduced fasting plasma free fatty acids and triglycerides.
 
Interactions
Ahsg interacts with 110 markers (Mir1a-1, Mir1a-2, Mir29a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (156)    Tissues (18)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 146
Northern blot 10
cDNA source data(740)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ahsg    NEW 
Molecular
reagents
All nucleic(742) cDNA(741) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000022868 (Evidence)
Entrez Gene 11625 (Evidence)
UniGene 197554
DFCI TC1573795, TC1682200, TC1732517
DoTS DT.101243782, DT.101286992, DT.102551281, DT.102551919, DT.522934, DT.55107619, DT.94310903
NIA Mouse Gene Index U016951
Consensus CDS Project CCDS28071.1
International Mouse Phenotyping Consortium Status Ahsg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022868 Ensembl Gene Model | MGI Sequence Detail 7397 C57BL/6J ±  kb
transcript ENSMUST00000023583 Ensembl | MGI Sequence Detail 1474 Not Applicable 
polypeptide ENSMUSP00000023583 Ensembl | MGI Sequence Detail 345 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(7) UniProt(4)
Polymorphisms
SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025760 Fetuin-A-type cystatin domain
InterPro IPR001363 Proteinase inhibitor I25C, fetuin, conserved site
InterPro IPR000010 Proteinase inhibitor I25, cystatin
Protein Ontology PR:000003862 alpha-2-HS-glycoprotein
References
(Earliest) J:31552 Yang F, et al., Human alpha 2-HS-glycoprotein/bovine fetuin homologue in mice: identification and developmental regulation of the gene. Biochim Biophys Acta. 1992 Mar 24;1130(2):149-56
(Latest) J:208341 Seth A, et al., Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
All references(49)
Other
accession IDs
MGD-MRK-35650

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory