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Ahsg Gene Detail
Summary
  • Symbol
    Ahsg
  • Name
    alpha-2-HS-glycoprotein
  • Synonyms
    fetuin-A
  • Feature Type
    protein coding gene
  • IDs
    MGI:107189
    NCBI Gene: 11625
  • Gene Overview
    MyGene.info: AHSG
Location & Maps
more
  • Sequence Map
    Chr16:22892042-22899438 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7397 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 13.74 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    AHSG, alpha 2-HS glycoprotein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AHSG, alpha 2-HS glycoprotein
    Orthology source: HomoloGene
  • Synonyms
    A2HS, AHS, FETUA, HSGA
  • Links
    NCBI Gene ID: 197
    neXtProt AC: NX_P02765

  • Chr Location
    3q27; chr3:186613061-186621318 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice lacking this gene exhibit defective inhibition of serum apatite formation, sometimes causing muscle calcification. They are resistant to weight gain on a high-fat diet and have increased insulin sensitivity and glucose clearance and reduced fasting plasma free fatty acids and triglycerides.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022868 Ensembl Gene Model | MGI Sequence Detail 7397 C57BL/6J ±  kb
transcript ENSMUST00000023583 Ensembl | MGI Sequence Detail 1474 Not Applicable  
polypeptide ENSMUSP00000023583 Ensembl | MGI Sequence Detail 345 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    64 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000003862 alpha-2-HS-glycoprotein
  • InterPro Domains
    IPR000010 Cystatin domain
    IPR025760 Fetuin-A-type cystatin domain
    IPR001363 Proteinase inhibitor I25C, fetuin, conserved site
Molecular
Reagents
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  • All nucleic 742
    cDNA 741
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-35650
References
more
  • Summaries
    All 49
    Developmental Gene Expression 9
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:31552 Yang F, et al., Human alpha 2-HS-glycoprotein/bovine fetuin homologue in mice: identification and developmental regulation of the gene. Biochim Biophys Acta. 1992 Mar 24;1130(2):149-56
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory