Arnt2
Gene Detail

Symbol

Name
ID

Arnt2
aryl hydrocarbon receptor nuclear translocator 2
MGI:107188

Synonyms

bHLHe1, mKIAA0307

Feature Type

protein coding gene

Genetic Map

Chromosome 7
48.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr7:84246281-84409959 bp, - strand From Ensembl annotation of GRCm38   163679 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:7230  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: aryl hydrocarbon receptor nuclear translocator
Gene Tree: Arnt2

Human
homologs

Human Homolog		ARNT2, aryl-hydrocarbon receptor nuclear translocator 2
NCBI Gene ID		9915
neXtProt AC		NX_Q9HBZ2
Human Synonyms		bHLHe1, WEDAS
Human Chr (Location)		15q24; chr15:80404350-80597937 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human ARNT2

Mutations,
alleles, and
phenotypes

All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for targeted mutations that inactivate this gene die shortly after birth, displaying impaired development of secretory neurons in the hypothalamus.

 

Interactions

Arnt2 interacts with 378 markers (Mir1b, Mir10a, Mir10b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (30 annotations)

Process	brain development, central nervous system development, ...
Component	cytoplasm, nucleus, ...
Function	aryl hydrocarbon receptor binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)

Data Summary: Results (446)    Tissues (275)    Images (26)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	438
RT-PCR	8

cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(24) Genomic(11) cDNA(11) Primer pair(2)
Microarray probesets(8)

Other database
links

Ensembl Gene Model	ENSMUSG00000015709 (Evidence)
Entrez Gene	11864 (Evidence)
DFCI	TC1697164, TC1597503, TC1580410
DoTS	DT.101381674, DT.101381670, DT.55269792, DT.524165
NIA Mouse Gene Index	U028811
Consensus CDS Project	CCDS59733.1
International Mouse Knockout Project Status	Arnt2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000015709	Ensembl Gene Model | MGI Sequence Detail	163679	C57BL/6J
transcript	ENSMUST00000085077	Ensembl | MGI Sequence Detail	5988	Not Applicable
polypeptide	ENSMUSP00000082154	Ensembl | MGI Sequence Detail	712	Not Applicable

All sequences(42) RefSeq(16) UniProt(1)

Polymorphisms

SNPs within 2kb(1574 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
InterPro	IPR001067	Nuclear translocator
InterPro	IPR001610	PAC motif
InterPro	IPR000014	PAS domain
InterPro	IPR013767	PAS fold
Protein Ontology	PR:000004304	aryl hydrocarbon receptor nuclear translocator 2

References

(Earliest) J:31945 Hirose K, et al., cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt). Mol Cell Biol. 1996 Apr;16(4):1706-13
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(54)

Other
accession IDs

MGD-MRK-35649