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Arnt2 Gene Detail
Summary
  • Symbol
    Arnt2
  • Name
    aryl hydrocarbon receptor nuclear translocator 2
  • Synonyms
    bHLHe1, mKIAA0307
  • Feature Type
    protein coding gene
  • IDs
    MGI:107188
    NCBI Gene: 11864
  • Gene Overview
    MyGene.info: ARNT2
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr7:84246278-84410176 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      163899 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 48.35 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ARNT2, aryl hydrocarbon receptor nuclear translocator 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARNT2, aryl hydrocarbon receptor nuclear translocator 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHe1, WEDAS
  • Links
    NCBI Gene ID: 9915
    neXtProt AC: NX_Q9HBZ2
    UniProt: Q9HBZ2

  • Chr Location
    15q25.1; chr15:80404350-80597937 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate this gene die shortly after birth, displaying impaired development of secretory neurons in the hypothalamus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    468
  • Tissues
    292
  • cDNA Data
    12
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000059598 VEGA Gene Model | MGI Sequence Detail 163899 C57BL/6J ±  kb
    transcript OTTMUST00000146143 VEGA | MGI Sequence Detail 6151 Not Applicable  
    polypeptide OTTMUSP00000076134 VEGA | MGI Sequence Detail 712 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1568 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 11
      cDNA 13
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-35649
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 20
      Gene Ontology 12
      Phenotypes 16
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    07/31/2018
    MGI 6.12     		The Jackson Laboratory