Arnt2
Gene Detail

Symbol Name ID

Arnt2 aryl hydrocarbon receptor nuclear translocator 2 MGI:107188

Synonyms

bHLHe1, mKIAA0307

Feature Type

protein coding gene

Genetic Map

Chromosome 7

48.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr7:84246278-84361673 bp, - strand From NCBI annotation of GRCm38   115396 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7230  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: aryl hydrocarbon receptor nuclear translocator
Gene Tree: Arnt2

Human homologs

Human Homolog		ARNT2, aryl-hydrocarbon receptor nuclear translocator 2
NCBI Gene ID		9915
neXtProt AC		NX_Q9HBZ2
Human Synonyms		bHLHe1
Human Chr (Location)		15q24; chr15:80404350-80597937 (+)  GRCh38

Alleles and phenotypes

All alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for targeted mutations that inactivate this gene die shortly after birth, displaying impaired development of secretory neurons in the hypothalamus.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	central nervous system development, negative regulation of apoptotic process, ...
Component	cytoplasm, nucleus, ...
Function	aryl hydrocarbon receptor binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)

Data Summary: Results (453)    Tissues (280)    Images (26)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 21, 23, 25, 27, 28

Assay Type	Results
RNA in situ	438
RT-PCR	15

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) Genomic(11) cDNA(11) Primer pair(2)
Microarray probesets(8)

Other database links

Ensembl Gene Model	ENSMUSG00000015709 (Evidence)
Entrez Gene	11864 (Evidence)
DFCI	TC1580410, TC1597503, TC1697164
DoTS	DT.101381670, DT.101381674, DT.524165, DT.55269792
NIA Mouse Gene Index	U028811
Consensus CDS Project	CCDS59733.1
International Mouse Knockout Project Status	Arnt2

Sequences

Length	Strain/Species
genomic	11864	NCBI Gene Model | MGI Sequence Detail	115396	C57BL/6J
transcript	NM_007488	RefSeq | MGI Sequence Detail	6073	C57BL/6
polypeptide	Q61324	UniProt | EBI | MGI Sequence Detail	712	Not Applicable

All sequences(42) RefSeq(16) UniProt(1)

Polymorphisms

SNPs within 2kb(1574 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
InterPro	IPR001067	Nuclear translocator
InterPro	IPR001610	PAC motif
InterPro	IPR000014	PAS domain
InterPro	IPR013767	PAS fold
Protein Ontology	PR:000004304	aryl hydrocarbon receptor nuclear translocator 2

Graphical View of Protein Domain Structure

References

(Earliest) J:31945 Hirose K, et al., cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt). Mol Cell Biol. 1996 Apr;16(4):1706-13
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(54)

Other accession IDs

MGD-MRK-35649