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Arnt2 Gene Detail
Summary
  • Symbol
    Arnt2
  • Name
    aryl hydrocarbon receptor nuclear translocator 2
  • Synonyms
    bHLHe1, mKIAA0307
  • Feature Type
    protein coding gene
  • IDs
    MGI:107188
    NCBI Gene: 11864
  • Gene Overview
    MyGene.info: ARNT2
Location & Maps
more
  • Sequence Map
    Chr7:84246278-84410176 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      163899 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 48.35 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ARNT2, aryl hydrocarbon receptor nuclear translocator 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARNT2, aryl hydrocarbon receptor nuclear translocator 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHe1, WEDAS
  • Links
    NCBI Gene ID: 9915
    neXtProt AC: NX_Q9HBZ2

  • Chr Location
    15q24; chr15:80404350-80597937 (+)  GRCh38.p2
Human Diseases
more
  • Diseases
    1 with human ARNT2 associations

Human Disease Mouse Models
       Webb-Dattani Syndrome; WEDAS   OMIM: 615926
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Arnt2
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Mice homozygous for targeted mutations that inactivate this gene die shortly after birth, displaying impaired development of secretory neurons in the hypothalamus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    28
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    458
  • Tissues
    285
  • cDNA Data
    11
  • Literature Summary
    16
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000059598 VEGA Gene Model | MGI Sequence Detail 163899 C57BL/6J ±  kb
transcript OTTMUST00000146143 VEGA | MGI Sequence Detail 6151 Not Applicable  
polypeptide OTTMUSP00000076134 VEGA | MGI Sequence Detail 712 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1568 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    Genomic 11
    cDNA 12
    Primer pair 2

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-35649
References
more
  • Summaries
    All 49
    Developmental Gene Expression 16
    Gene Ontology 11
    Phenotypes 16
  • Earliest
    J:31945 Hirose K, et al., cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt). Mol Cell Biol. 1996 Apr;16(4):1706-13
  • Latest
    J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory