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Cct8 Gene Detail
Summary
  • Symbol
    Cct8
  • Name
    chaperonin containing Tcp1, subunit 8 (theta)
  • Synonyms
    Cctq, Tcpq
  • Feature Type
    protein coding gene
  • IDs
    MGI:107183
    NCBI Gene: 12469
  • Gene Overview
    MyGene.info: CCT8
Location & Maps
more
  • Sequence Map
    Chr16:87483326-87495873 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      12548 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 49.57 cM, cytoband C3.3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CCT8, chaperonin containing TCP1 subunit 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CCT8, chaperonin containing TCP1 subunit 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C21orf112, Cctq, D21S246, PRED71
  • Links
    NCBI Gene ID: 10694
    neXtProt AC: NX_P50990

  • Chr Location
    21q22.11; chr21:29056322-29073797 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 4802
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: CCT8
  • Gene Tree
    Cct8
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    17
  • Gene trapped
    13
  • Targeted
    4
  • Genomic Mutations
    2 involving Cct8
  • Incidental Mutations
    Mutagenetix , APF
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    68
  • Tissues
    66
  • cDNA Data
    406
  • Literature Summary
    4
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040145 VEGA Gene Model | MGI Sequence Detail 12548 C57BL/6J ±  kb
transcript OTTMUST00000104328 VEGA | MGI Sequence Detail 2394 Not Applicable  
polypeptide OTTMUSP00000058377 VEGA | MGI Sequence Detail 548 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    35 from dbSNP Build 142
Protein
Information
less
  • UniProt
    12 Sequences
  • Protein Ontology
    PR:000005157 T-complex protein 1 subunit theta
  • InterPro Domains
    IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)
    IPR002423 Chaperonin Cpn60/TCP-1 family
    IPR002194 Chaperonin TCP-1, conserved site
    IPR027409 GroEL-like apical domain
    IPR027413 GroEL-like equatorial domain
    IPR012721 T-complex protein 1, theta subunit
    IPR027410 TCP-1-like chaperonin intermediate domain
Molecular
Reagents
less
  • All nucleic 407
    cDNA 406
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-35644, MGI:2146380
References
more
  • Summaries
    All 44
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:25228 Kubota H, et al., Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin. Curr Biol. 1994 Feb 1;4(2):89-99
  • Latest
    J:205312 Tarkar A, et al., DYX1C1 is required for axonemal dynein assembly and ciliary motility. Nat Genet. 2013 Sep;45(9):995-1003
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory