About   Help   FAQ
Cct8 Gene Detail
Summary
  • Symbol
    Cct8
  • Name
    chaperonin containing TCP1 subunit 8
  • Synonyms
    Cctq, Tcpq
  • Feature Type
    protein coding gene
  • IDs
    MGI:107183
    NCBI Gene: 12469
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:87280213-87292757 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 49.57 cM, cytoband C3.3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    594 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107183
 protein coding gene Chr16:87280213-87292761 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022979
 protein coding gene Chr16:88205870-88218231 (-)
A/J MGP_AJ_G0022947
 protein coding gene Chr16:84136056-84149214 (-)
AKR/J MGP_AKRJ_G0022917
 protein coding gene Chr16:86697515-86709941 (-)
BALB/cJ MGP_BALBcJ_G0022949
 protein coding gene Chr16:84661911-84674391 (-)
C3H/HeJ MGP_C3HHeJ_G0022711
 protein coding gene Chr16:87253025-87265586 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023396
 protein coding gene Chr16:91066368-91079272 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020900
 protein coding gene Chr16:81991086-82003539 (-)
CAST/EiJ MGP_CASTEiJ_G0022233
 protein coding gene Chr16:87632795-87645427 (-)
CBA/J MGP_CBAJ_G0022680
 protein coding gene Chr16:94971218-94984711 (-)
DBA/2J MGP_DBA2J_G0022814
 protein coding gene Chr16:84058601-84071011 (-)
FVB/NJ MGP_FVBNJ_G0022789
 protein coding gene Chr16:83167606-83180092 (-)
LP/J MGP_LPJ_G0022883
 protein coding gene Chr16:87889205-87901565 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022808
 protein coding gene Chr16:99523763-99537651 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023414
 protein coding gene Chr16:87160962-87179320 (-)
PWK/PhJ MGP_PWKPhJ_G0021976
 protein coding gene Chr16:84172545-84184925 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021806
 protein coding gene Chr16:86689988-86702539 (-)
WSB/EiJ MGP_WSBEiJ_G0022281
 protein coding gene Chr16:87399536-87413155 (-)



Homology
more
  • Human Ortholog
    CCT8, chaperonin containing TCP1 subunit 8
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCT8, chaperonin containing TCP1 subunit 8
  • Synonyms
    C21orf112, Cctq, D21S246, PRED71
  • Links
    NCBI Gene ID: 10694
    UniProt: P50990

  • Chr Location
    21q21.3; chr21:29055805-29073797 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, embryos fail to hatch from the zona pellucida and die after 3 days in culture, never forming outgrowths.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    774
  • Tissues
    66
  • cDNA Data
    407
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12469 NCBI Gene Model | MGI Sequence Detail 12545 C57BL/6J ±  kb
transcript NM_009840 RefSeq | MGI Sequence Detail 2391 C57BL/6  
polypeptide P42932 UniProt | EBI | MGI Sequence Detail 548 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    12 Sequences
  • Protein Ontology
    PR:000005157 T-complex protein 1 subunit theta
    (term hierarchy)
  • EC
    3.6.1.-
  • InterPro Domains
    IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)
    IPR002423 Chaperonin Cpn60/GroEL/TCP-1 family
    IPR002194 Chaperonin TCP-1, conserved site
    IPR027409 GroEL-like apical domain superfamily
    IPR027413 GroEL-like equatorial domain superfamily
    IPR012721 T-complex protein 1, theta subunit
    IPR027410 TCP-1-like chaperonin intermediate domain superfamily
  • GlyGen
    P42932 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 409
    cDNA 407
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-35644, MGI:2146380
References
more
  • Summaries
    All 62
    Developmental Gene Expression 4
    Gene Ontology 13
    Phenotypes 20
  • Earliest
    J:18119 O'Bryan JP, et al., axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol Cell Biol. 1991 Oct;11(10):5016-31
  • Latest
    J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory