Slc26a3
Gene Detail

Symbol Name ID

Slc26a3 solute carrier family 26, member 3 MGI:107181

Synonyms

9030623B18Rik, 9130013M11Rik, Dra

Feature Type

protein coding gene

Genetic Map

Chromosome 12

13.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr12:31390871-31473917 bp, + strand From VEGA annotation of GRCm38   83047 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55435  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: sulfate transport protein
Gene Tree: Slc26a3

Human homologs

Human Homolog		SLC26A3, solute carrier family 26, member 3
NCBI Gene ID		1811
neXtProt AC		NX_P40879
Human Synonyms		CLD, DRA
Human Chr (Location)		7q31; chr7:107405912-107443678 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SLC26A3

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygotes for a null allele display partial postnatal lethality; survivors are small and show lower luminal Cl-/HCO3- exchange activity, acidic chloridorrhea, volume depletion, upregulation of ion transporters, dilated colons, higher crypt proliferation and plasma aldosterone, and premature death.

 
Human Diseases Modeled Using Mouse Slc26a3 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	anion transport, ion transmembrane transport, ...
Component	apical plasma membrane, brush border membrane, ...
Function	anion:anion antiporter activity, antiporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 23

Assay Type	Results
RNA in situ	1

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) Genomic(1) cDNA(9)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000035459 (Evidence)
Ensembl Gene Model	ENSMUSG00000001225 (Evidence)
Entrez Gene	13487 (Evidence)
DFCI	TC1586988, TC1591497, TC1618269, TC1620936
DoTS	DT.101298714, DT.40138794, DT.40139642, DT.40144334, DT.94181420
NIA Mouse Gene Index	U013839
Consensus CDS Project	CCDS25863.1
International Mouse Knockout Project Status	Slc26a3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035459	VEGA Gene Model | MGI Sequence Detail	83047	C57BL/6J
transcript	OTTMUST00000090744	VEGA | MGI Sequence Detail	2908	Not Applicable
polypeptide	OTTMUSP00000049827	VEGA | MGI Sequence Detail	757	Not Applicable

All sequences(55) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(130 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002645	STAS domain
InterPro	IPR001902	Sulphate anion transporter
InterPro	IPR018045	Sulphate anion transporter, conserved site
InterPro	IPR011547	Sulphate transporter
Protein Ontology	PR:000015038	chloride anion exchanger

References

(Earliest) J:25525 Silberg DG, et al., The Down regulated in Adenoma (dra) gene encodes an intestine-specific membrane sulfate transport protein. J Biol Chem. 1995 May 19;270(20):11897-902
(Latest) J:192414 Dawson PA, et al., Placental, renal, and ileal sulfate transporter gene expression in mouse gestation. Biol Reprod. 2012 Aug;87(2):43
All references(42)

Other accession IDs

MGD-MRK-35642, MGI:1918793, MGI:1918868, MGI:2144991