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Slc26a3
Gene Detail
Symbol

Name
ID
Slc26a3
solute carrier family 26, member 3
MGI:107181
Synonyms
9030623B18Rik, 9130013M11Rik, Dra
Feature Type
protein coding gene
Genetic Map
Chromosome 12
13.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr12:31390871-31473917 bp, + strand
From VEGA annotation of GRCm38

  83047 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55435  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: sulfate transport protein
Gene Tree: Slc26a3

Human
homologs
Human Homolog SLC26A3, solute carrier family 26 (anion exchanger), member 3
NCBI Gene ID 1811
neXtProt AC  NX_P40879
Human Synonyms  CLD, DRA
Human Chr (Location)  7q31; chr7:107765467-107803233 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC26A3
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele display partial postnatal lethality; survivors are small and show lower luminal Cl-/HCO3- exchange activity, acidic chloridorrhea, volume depletion, upregulation of ion transporters, dilated colons, higher crypt proliferation and plasma aldosterone, and premature death.
 
Human Diseases Modeled Using Mouse Slc26a3 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Slc26a3 interacts with 231 markers (Mir10a, Mir17, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process anion transport, bicarbonate transport, ...
Component apical plasma membrane, brush border membrane, ...
Function anion:anion antiporter activity, antiporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) Genomic(1) cDNA(9)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000035459 (Evidence)
Ensembl Gene ModelENSMUSG00000001225 (Evidence)
Entrez Gene13487 (Evidence)
DFCITC1620936, TC1618269, TC1591497, TC1586988
DoTSDT.40139642, DT.101298714, DT.40138794, DT.94181420, DT.40144334
NIA Mouse Gene IndexU013839
Consensus CDS ProjectCCDS25863.1
International Mouse Knockout Project StatusSlc26a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035459 VEGA Gene Model | MGI Sequence Detail 83047 C57BL/6J ±  kb
transcript OTTMUST00000090744 VEGA | MGI Sequence Detail 2908 Not Applicable 
polypeptide OTTMUSP00000049827 VEGA | MGI Sequence Detail 757 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(2) UniProt(11)
Polymorphisms
RFLP(1) : SNPs within 2kb(563 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002645 STAS domain
InterPro IPR001902 Sulphate anion transporter
InterPro IPR018045 Sulphate anion transporter, conserved site
InterPro IPR011547 Sulphate transporter
Protein Ontology PR:000015038 chloride anion exchanger
References
(Earliest) J:25525 Silberg DG, et al., The Down regulated in Adenoma (dra) gene encodes an intestine-specific membrane sulfate transport protein. J Biol Chem. 1995 May 19;270(20):11897-902
(Latest) J:210569 Freel RW, et al., Transcellular oxalate and Cl- absorption in mouse intestine is mediated by the DRA anion exchanger Slc26a3, and DRA deletion decreases urinary oxalate. Am J Physiol Gastrointest Liver Physiol. 2013 Oct 1;305(7):G520-7
All references(44)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-35642, MGI:1918793, MGI:1918868, MGI:2144991

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory