Fosl1
Gene Detail

Symbol Name ID

Fosl1 fos-like antigen 1 MGI:107179

Synonyms

fra-1, Fra1

Feature Type

protein coding gene

Genetic Map

Chromosome 19

4.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr19:5447698-5455938 bp, + strand From NCBI annotation of GRCm38   8241 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3967  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: fos transforming protein
Gene Tree: Fosl1

Human homologs

Human Homolog		FOSL1, FOS-like antigen 1
NCBI Gene ID		8061
neXtProt AC		NX_P15407
Human Synonyms		FRA, fra-1, FRA1
Human Chr (Location)		11q13; chr11:65659692-65667997 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Homozygous inactivation of this gene leads to in utero lethality. Embryos homozygous for a reporter/null allele are severely growth retarded and display defects in the extra-embryonic compartment, including a highly abnormal yolk sac and a narrow, largely avascular placental labyrinth layer.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	cellular response to extracellular stimulus, in utero embryonic development, ...
Component	cytosol, intracellular membrane-bounded organelle, ...
Function	DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (126)    Tissues (115)    Images (3)
Theiler Stages: 16, 19, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	119
RT-PCR	7

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(1) cDNA(23) Primer pair(3)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000024912 (Evidence)
Entrez Gene	14283 (Evidence)
UniGene	6215
DFCI	TC1580200
DoTS	DT.40173429
NIA Mouse Gene Index	U038721
Consensus CDS Project	CCDS29464.1
International Mouse Knockout Project Status	Fosl1

Sequences

Length	Strain/Species
genomic	14283	NCBI Gene Model | MGI Sequence Detail	8241	C57BL/6J
transcript	NM_010235	RefSeq | MGI Sequence Detail	1705	C57BL/6
polypeptide	P48755	UniProt | EBI | MGI Sequence Detail	273	Not Applicable

All sequences(21) RefSeq(2) UniProt(4)

Polymorphisms

PCR(1) : SNPs(60 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004827	Basic-leucine zipper domain
InterPro	IPR000837	Fos transforming protein
Protein Ontology	PR:000007599	fos-related antigen 1

Graphical View of Protein Domain Structure

References

(Earliest) J:33399 Jeske YW, et al., Analysis of the role of Amh and Fra1 in the Sry regulatory pathway. Mol Reprod Dev. 1996 Jun;44(2):153-8
(Latest) J:194035 Kan A, et al., c-Jun is required for the specification of joint cell fates. Genes Dev. 2013 Mar 1;27(5):514-24
All references(58)

Other accession IDs

MGD-MRK-35640, MGI:2147739