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Fosl1 Gene Detail
Summary
  • Symbol
    Fosl1
  • Name
    fos-like antigen 1
  • Synonyms
    fra-1, Fra1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107179
    NCBI Gene: 14283
  • Gene Overview
    MyGene.info: FOSL1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5447698-5455938 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.33 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    78 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107179
protein coding gene Chr19:5447698-5455945 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024706
protein coding gene Chr19:2416940-2425183 (+)
A/J MGP_AJ_G0024672
protein coding gene Chr19:2282360-2290591 (+)
AKR/J MGP_AKRJ_G0024645
protein coding gene Chr19:2340268-2348497 (+)
BALB/cJ MGP_BALBcJ_G0024672
protein coding gene Chr19:2274939-2284334 (+)
C3H/HeJ MGP_C3HHeJ_G0024440
protein coding gene Chr19:2349834-2358065 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025119
protein coding gene Chr19:2470854-2480774 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022549
protein coding gene Chr19:2184207-2192725 (+)
CAST/EiJ MGP_CASTEiJ_G0023912
protein coding gene Chr19:2377209-2385457 (+)
CBA/J MGP_CBAJ_G0024412
protein coding gene Chr19:2581386-2590164 (+)
DBA/2J MGP_DBA2J_G0024539
protein coding gene Chr19:2261356-2269969 (+)
FVB/NJ MGP_FVBNJ_G0024506
protein coding gene Chr19:2268517-2276750 (+)
LP/J MGP_LPJ_G0024625
protein coding gene Chr19:2396377-2404647 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024536
protein coding gene Chr19:2435624-2444836 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025167
protein coding gene Chr19:2357062-2366320 (+)
PWK/PhJ MGP_PWKPhJ_G0023658
protein coding gene Chr19:2298450-2306871 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023463
protein coding gene Chr19:2340034-2348452 (+)
WSB/EiJ MGP_WSBEiJ_G0023974
protein coding gene Chr19:2368973-2377238 (+)



Homology
more
  • Human Ortholog
    FOSL1, FOS like 1, AP-1 transcription factor subunit
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FOSL1, FOS like 1, AP-1 transcription factor subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FRA, fra-1, FRA1
  • Links
    NCBI Gene ID: 8061
    neXtProt AC: NX_P15407
    UniProt: P15407

  • Chr Location
    11q13.1; chr11:65892136-65900526 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    62 phenotypes from 5 alleles in 5 genetic backgrounds
    32 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to in utero lethality. Embryos homozygous for a reporter/null allele are severely growth retarded and display defects in the extra-embryonic compartment, including a highly abnormal yolk sac and a narrow, largely avascular placental labyrinth layer.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14283 NCBI Gene Model | MGI Sequence Detail 8241 C57BL/6J ±  kb
    transcript NM_010235 RefSeq | MGI Sequence Detail 1705 C57BL/6  
    polypeptide P48755 UniProt | EBI | MGI Sequence Detail 273 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 1
      cDNA 24
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35640, MGI:2147739
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 13
      Diseases 1
      Gene Ontology 8
      Phenotypes 27
    • Earliest
      J:33399 Jeske YW, et al., Analysis of the role of Amh and Fra1 in the Sry regulatory pathway. Mol Reprod Dev. 1996 Jun;44(2):153-8
    • Latest
      J:245773 Paikari A, et al., The eutheria-specific miR-290 cluster modulates placental growth and maternal-fetal transport. Development. 2017 Oct 15;144(20):3731-3743

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory