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Fosl1
Gene Detail
Symbol

Name
ID
Fosl1
fos-like antigen 1
MGI:107179
Synonyms
fra-1, Fra1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
4.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr19:5447698-5455938 bp, + strand
From NCBI annotation of GRCm38

  8241 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3967  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FOSL1
Protein SuperFamily: fos transforming protein
Gene Tree: Fosl1

Human
homologs
FOSL1, FOS-like antigen 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8061
neXtProt AC: NX_P15407

Human Synonyms: FRA, fra-1, FRA1

Human Chr (Location): 11q13; chr11:65892136-65900526 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from APF , CvDC )
 
Homozygous inactivation of this gene leads to in utero lethality. Embryos homozygous for a reporter/null allele are severely growth retarded and display defects in the extra-embryonic compartment, including a highly abnormal yolk sac and a narrow, largely avascular placental labyrinth layer.
 
Interactions
Fosl1 interacts with 114 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (126)    Tissues (115)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 119
RT-PCR 7
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fosl1 ; ZFIN fosl1a    NEW 
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(23) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000024912 (Evidence)
Entrez Gene 14283 (Evidence)
UniGene 6215
DFCI TC1580200
DoTS DT.40173429
NIA Mouse Gene Index U038721
Consensus CDS Project CCDS29464.1
International Mouse Phenotyping Consortium Status Fosl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14283 NCBI Gene Model | MGI Sequence Detail 8241 C57BL/6J ±  kb
transcript NM_010235 RefSeq | MGI Sequence Detail 1705 C57BL/6 
polypeptide P48755 UniProt | EBI | MGI Sequence Detail 273 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(4)
Polymorphisms
PCR(1) : SNPs within 2kb(78 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR000837 Fos transforming protein
Protein Ontology PR:000007599 fos-related antigen 1
Graphical View of Protein Domain Structure
References
(Earliest) J:33399 Jeske YW, et al., Analysis of the role of Amh and Fra1 in the Sry regulatory pathway. Mol Reprod Dev. 1996 Jun;44(2):153-8
(Latest) J:217601 Delgado-Olguin P, et al., Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature. Development. 2014 Dec;141(23):4610-7
All references(62)
Other
accession IDs
MGD-MRK-35640, MGI:2147739

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory