Fosl1 MGI Mouse Gene Detail - MGI:107179

Symbol

Fosl1
Name

fos-like antigen 1
Synonyms

fra-1, Fra1

Feature Type

protein coding gene
IDs

MGI:107179
NCBI Gene: 14283
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr19:5497726-5505966 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 4.33 cM
Mapping Data

7 experiments

SNPs within 2kb

253 from dbSNP Build 142
Strain Annotations

19
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107179	protein coding gene	Chr19:5497575-5505974 (+)
129S1/SvImJ	ENSMUSG00200044828	protein coding gene	Chr19:2259500-2267901 (+)
A/J	ENSMUSG00195052187	protein coding gene	Chr19:2653848-2662236 (+)
AKR/J	ENSMUSG00220039412	protein coding gene	Chr19:2426969-2435359 (+)
BALB/cJ	ENSMUSG00180049652	protein coding gene	Chr19:3028567-3036957 (+)
C3H/HeJ	ENSMUSG00175009907	protein coding gene	Chr19:2278785-2287171 (+)
C57BL/6NJ	ENSMUSG00215039061	protein coding gene	Chr19:2497705-2506104 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022549	protein coding gene	Chr19:2184207-2192725 (+)
CAST/EiJ	ENSTCUG00005042644	protein coding gene	Chr19:2418480-2426885 (+)
CBA/J	ENSMUSG00210048706	protein coding gene	Chr19:2281069-2289467 (+)
DBA/2J	ENSMUSG00185043941	protein coding gene	Chr19:2657528-2665927 (+)
FVB/NJ	ENSMUSG00205045731	protein coding gene	Chr19:2664678-2673068 (+)
JF1/MsJ	ENSUMUG00000014028	protein coding gene	Chr19:2635293-2643720 (+)
LP/J	ENSMUSG00230052489	protein coding gene	Chr19:3566409-3574808 (+)
NOD/ShiLtJ	ENSMUSG00190048720	protein coding gene	Chr19:2188365-2196752 (+)
NZO/HlLtJ	ENSMUSG00225026390	protein coding gene	Chr19:7275179-7283578 (+)
PWK/PhJ	ENSLUMG00010003297	protein coding gene	Chr19:2403966-2412380 (+)
SPRET/EiJ	ENSMSPG00010046672	protein coding gene	Chr19:2393844-2402427 (+)
WSB/EiJ	ENSIUOG00005050535	protein coding gene	Chr19:2296520-2304912 (+)

Human Ortholog

FOSL1, FOS like 1, AP-1 transcription factor subunit

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FOSL1, FOS like 1, AP-1 transcription factor subunit
Synonyms

FRA, fra-1, FRA1
Links

HGNC:13718

NCBI Gene ID: 8061

UniProt: P15407
Chr Location

11q13.1; chr11:65892049-65900573 (-) GRCh38

MGI Vertebrate Homology

Fosl1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FOSL1
Gene Tree

Fosl1

Diseases

1 with human FOSL1 associations

				Human Disease	Mouse Models
				stomach cancer IDs stomach cancer DOID:10534 DOID:10539 DOID:10542 DOID:10543 DOID:4713 ICD10CM:C16 ICD10CM:C16.2 ICD10CM:C16.5 ICD10CM:C16.6 ICD9CM:151 ICD9CM:151.4 ICD9CM:151.5 ICD9CM:151.6 ICD9CM:151.9 MESH:D013274 NCI:C194067 NCI:C194069 NCI:C194070 NCI:C3387 NCI:C9331 OMIM:613659 UMLS_CUI:C0024623 UMLS_CUI:C0038356 UMLS_CUI:C0153421 UMLS_CUI:C0153422 UMLS_CUI:C0153423

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

62 phenotypes from 5 alleles in 5 genetic backgrounds
18 phenotypes from multigenic genotypes
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

5
Targeted

7
Transgenic

1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene leads to in utero lethality. Embryos homozygous for a reporter/null allele are severely growth retarded and display defects in the extra-embryonic compartment, including a highly abnormal yolk sac and a narrow, largely avascular placental labyrinth layer.

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All GO Annotations

43
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

743
Tissues

130
cDNA Data

24
Literature Summary

21

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fosl1

ZFIN fosl1a, fosl1b

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All Sequences

41
RefSeq

2
UniProt

5
CCDS

CCDS29464.1

Ensembl

ENSMUSG00000024912 (Evidence)
NCBI Gene

14283

			Length	Strain/Species	Flank
genomic	14283	NCBI Gene Model \| MGI Sequence Detail	8241	C57BL/6J	± kb
transcript	NM_010235	RefSeq \| MGI Sequence Detail	1705	ZRU/MplStud
polypeptide	P48755	UniProt \| EBI \| MGI Sequence Detail	273	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007599 Fos-related antigen 1

(term hierarchy)
InterPro Domains

IPR000837 AP-1 transcription factor

IPR004827 Basic-leucine zipper domain

IPR046347 Basic-leucine zipper domain superfamily
GlyGen

P48755 1 site, 1 O-linked glycan (1 site)

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All nucleic 33

Genomic 1

cDNA 25

Primer pair 7

Microarray probesets 4

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MGD-MRK-35640, MGI:2147739

Summaries

All 100

Developmental Gene Expression 21

Diseases 1

Gene Ontology 11

Phenotypes 36
Earliest

J:23980 Carrasco D, et al., Tissue-specific expression of the fos-related transcription factor fra-2 during mouse development. Oncogene. 1995 Mar 16;10(6):1069-79
Latest

J:375759 Alam Z, et al., Fosl1 is a transcriptional effector of BRAF (V600E)-driven intestinal tumorigenesis. iScience. 2025 Nov 21;28(11):113875

TSS for Fosl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154419	Chr19:5497720-5497739 (+)	4 bp
Tssr5411	Chr19:5497752-5497757 (+)	29 bp
Tssr154420	Chr19:5497887-5497894 (+)	165 bp
Tssr154421	Chr19:5497914-5497933 (+)	198 bp
Tssr154422	Chr19:5500261-5500310 (+)	2,560 bp
Tssr154423	Chr19:5504451-5504457 (+)	6,728 bp
Tssr154424	Chr19:5505077-5505096 (+)	7,361 bp
Tssr154425	Chr19:5505618-5505640 (+)	7,903 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24