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Fosl1 Gene Detail
Summary
  • Symbol
    Fosl1
  • Name
    fos-like antigen 1
  • Synonyms
    fra-1, Fra1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107179
    NCBI Gene: 14283
  • Gene Overview
    MyGene.info: FOSL1
  • Alliance
Location & Maps
more
  • Genetic Map
    Chromosome 19, 4.33 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    FOSL1, FOS like 1, AP-1 transcription factor subunit
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FOSL1, FOS like 1, AP-1 transcription factor subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FRA, fra-1, FRA1
  • Links
    NCBI Gene ID: 8061
    neXtProt AC: NX_P15407
    UniProt: P15407

  • Chr Location
    11q13.1; chr11:65892136-65900526 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    62 phenotypes from 5 alleles in 5 genetic backgrounds
    32 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to in utero lethality. Embryos homozygous for a reporter/null allele are severely growth retarded and display defects in the extra-embryonic compartment, including a highly abnormal yolk sac and a narrow, largely avascular placental labyrinth layer.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14283 NCBI Gene Model | MGI Sequence Detail 8241 C57BL/6J ±  kb
    transcript NM_010235 RefSeq | MGI Sequence Detail 1705 C57BL/6  
    polypeptide P48755 UniProt | EBI | MGI Sequence Detail 273 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      78 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 1
      cDNA 23
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35640, MGI:2147739
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 13
      Diseases 1
      Gene Ontology 6
      Phenotypes 25
    • Earliest
      J:33399 Jeske YW, et al., Analysis of the role of Amh and Fra1 in the Sry regulatory pathway. Mol Reprod Dev. 1996 Jun;44(2):153-8
    • Latest
      J:245773 Paikari A, et al., The eutheria-specific miR-290 cluster modulates placental growth and maternal-fetal transport. Development. 2017 Oct 15;144(20):3731-3743

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory