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Fosl1 Gene Detail
Summary
  • Symbol
    Fosl1
  • Name
    fos-like antigen 1
  • Synonyms
    fra-1, Fra1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107179
    NCBI Gene: 14283
  • Gene Overview
    MyGene.info: FOSL1
Location & Maps
more
  • Genetic Map
    Chromosome 19, 4.33 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    FOSL1, FOS like 1, AP-1 transcription factor subunit
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FOSL1, FOS like 1, AP-1 transcription factor subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FRA, fra-1, FRA1
  • Links
    NCBI Gene ID: 8061
    neXtProt AC: NX_P15407

  • Chr Location
    11q13; chr11:65892136-65900526 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    59 phenotypes from 5 alleles in 5 genetic backgrounds
    32 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    1
  • Targeted
    7
  • Transgenic
    1
  • Incidental Mutations
    APF , CvDC
Homozygous inactivation of this gene leads to in utero lethality. Embryos homozygous for a reporter/null allele are severely growth retarded and display defects in the extra-embryonic compartment, including a highly abnormal yolk sac and a narrow, largely avascular placental labyrinth layer.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14283 NCBI Gene Model | MGI Sequence Detail 8241 C57BL/6J ±  kb
transcript NM_010235 RefSeq | MGI Sequence Detail 1705 C57BL/6  
polypeptide P48755 UniProt | EBI | MGI Sequence Detail 273 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    78 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000007599 fos-related antigen 1
  • InterPro Domains
    IPR000837 AP-1 transcription factor
    IPR004827 Basic-leucine zipper domain
Molecular
Reagents
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  • All nucleic 27
    Genomic 1
    cDNA 23
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-35640, MGI:2147739
References
more
  • Summaries
    All 60
    Developmental Gene Expression 11
    Gene Ontology 7
    Phenotypes 23
  • Earliest
    J:33399 Jeske YW, et al., Analysis of the role of Amh and Fra1 in the Sry regulatory pathway. Mol Reprod Dev. 1996 Jun;44(2):153-8
  • Latest
    J:217601 Delgado-Olguin P, et al., Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature. Development. 2014 Dec;141(23):4610-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory