About   Help   FAQ
Hmx1
Gene Detail
Symbol

Name
ID
Hmx1
H6 homeobox 1
MGI:107178
Synonyms
Nkx5-3
Feature Type
protein coding gene
Genetic Map
Chromosome 5
18.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:35389108-35399730 bp, + strand
From VEGA annotation of GRCm38

  10623 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49241  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

HCOP human homology predictions: HMX1
Gene Tree: Hmx1

Human
homologs
HMX1, H6 family homeobox 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3166
neXtProt AC: NX_Q9NP08

Human Synonyms: H6, NKX5-3

Human Chr (Location): 4p16.1; chr4:8846077-8871817 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HMX1

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(2) Radiation induced(5) Spontaneous(1) Targeted(2)
Genomic Mutations involving Hmx1 (6)
 
Mice homozygous for a spontaneous mutation show perinatal lethality, reduced body mass and low set, laterally-protruding ears. In addition to these phenotypes, mice homozygous for an ENU mutation can display small eyes, mild cranial defects, and perinatal semilethality associated with exencephaly.
 
Human Diseases Modeled in Mice Using Hmx1 (1)    Mutations Annotated to Human Diseases (6)    Phenotype Images(11)
Interactions
Hmx1 interacts with 67 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (14 records)
Data Summary: Results (112)    Tissues (97)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 112
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HMX1 ; Xenbase hmx1 ; ZFIN hmx1    NEW 
Molecular
reagents
All nucleic(9) Genomic(3) cDNA(4) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000037283 (Evidence)
Ensembl Gene Model ENSMUSG00000067438 (Evidence)
Entrez Gene 15371 (Evidence)
NIA Mouse Gene Index U005499
Consensus CDS Project CCDS19228.1
International Mouse Phenotyping Consortium Status Hmx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037283 VEGA Gene Model | MGI Sequence Detail 10623 C57BL/6J ±  kb
transcript OTTMUST00000096187 VEGA | MGI Sequence Detail 1497 Not Applicable 
polypeptide OTTMUSP00000053711 VEGA | MGI Sequence Detail 332 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(9 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008646 homeobox protein HMX1
References
(Earliest) J:139486 Mentzer RM, et al., The effects of dopamine and isoproterenol on the pulmonary circulation. J Thorac Cardiovasc Surg. 1976 Jun;71(6):807-14
(Latest) J:221159 Stubbusch J, et al., Lineage and stage specific requirement for Dicer1 in sympathetic ganglia and adrenal medulla formation and maintenance. Dev Biol. 2015 Apr 15;400(2):210-23
All references(45)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-35639

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/30/2015
MGI 5.22
The Jackson Laboratory