About   Help   FAQ
Hmx1
Gene Detail
 Symbol
Name
ID
Hmx1
H6 homeobox 1
MGI:107178
Synonyms Nkx5-3
Feature Type protein coding gene
Genetic Map
Chromosome 5
18.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:35389108-35399730 bp, + strand
From VEGA annotation of GRCm38

  10623 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49241  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Hmx1

Human
homologs
Human Homolog HMX1, H6 family homeobox 1
NCBI Gene ID 3166
neXtProt AC  NX_Q9NP08
Human Synonyms  H6, NKX5-3
Human Chr (Location)  4p16.1; chr4:8846077-8871817 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human HMX1
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(2) Radiation induced(4) Spontaneous(1) Targeted(2)
Genomic Mutations involving Hmx1 (5)
 
Mice homozygous for a spontaneous mutation show perinatal lethality, reduced body mass and low set, laterally-protruding ears. In addition to these phenotypes, mice homozygous for an ENU mutation can display small eyes, mild cranial defects, and perinatal semilethality associated with exencephaly.
 
Human Diseases Modeled Using Mouse Hmx1 (1)    Alleles Annotated to Human Diseases(6)    Phenotype Images(7)
Interactions
Hmx1 interacts with 68 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process multicellular organismal development, negative regulation of transcription, DNA-templated, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (112)    Tissues (97)    Images (26)
Theiler Stages: 17, 18, 20, 21, 22, 23, 26, 27, 28
Assay TypeResults
RNA in situ 112
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) Genomic(3) cDNA(4) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000037283 (Evidence)
Ensembl Gene ModelENSMUSG00000067438 (Evidence)
Entrez Gene15371 (Evidence)
NIA Mouse Gene IndexU005499
Consensus CDS ProjectCCDS19228.1
International Mouse Knockout Project StatusHmx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037283 VEGA Gene Model | MGI Sequence Detail 10623 C57BL/6J ±  kb
transcript OTTMUST00000096187 VEGA | MGI Sequence Detail 1497 Not Applicable 
polypeptide OTTMUSP00000053711 VEGA | MGI Sequence Detail 332 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(4) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(9 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008646 homeobox protein HMX1
References (Earliest) J:139486 Mentzer RM, et al., The effects of dopamine and isoproterenol on the pulmonary circulation. J Thorac Cardiovasc Surg. 1976 Jun;71(6):807-14
(Latest) J:205298 Boulling A, et al., Identification of HMX1 target genes: a predictive promoter model approach. Mol Vis. 2013;19:1779-94
All references(44)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-35639

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory