Aurkb
Gene Detail

Symbol Name ID

Aurkb aurora kinase B MGI:107168

Synonyms

Aik2, AIRK2, aurora B, IPL1, STK-1, Stk12, Stk5

Feature Type

protein coding gene

Genetic Map

Chromosome 11

42.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr11:69045647-69051664 bp, + strand From VEGA annotation of GRCm38   6018 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55807  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Aurkb

Human homologs

Human Homolog		AURKB, aurora kinase B
NCBI Gene ID		9212
neXtProt AC		NX_Q96GD4
Human Synonyms		AIK2, AIM1, AIM-1, ARK2, AurB, aurkb-sv1, aurkb-sv2, IPL1, PPP1R48, STK12, STK5
Human Chr (Location)		17p13.1; chr17:8108049-8113944 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(18) : Targeted(8) Gene trapped(10)

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	cell cycle, cell division, ...
Component	chromocenter, chromosome, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (166)    Tissues (152)    Images (22)
Theiler Stages: 13, 20, 22, 23, 24, 28

Assay Type	Results
RNA in situ	109
Northern blot	2
RT-PCR	55

cDNA source data(102)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(107) Genomic(1) cDNA(103) Primer pair(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000005961 (Evidence)
Ensembl Gene Model	ENSMUSG00000020897 (Evidence)
Entrez Gene	20877 (Evidence)
UniGene	3488
DFCI	TC1576436
DoTS	DT.101159831, DT.101407594, DT.94146103, DT.94256776
NIA Mouse Gene Index	U012804
EC	2.7.11.1
Consensus CDS Project	CCDS24877.1
International Mouse Knockout Project Status	Aurkb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005961	VEGA Gene Model | MGI Sequence Detail	6018	C57BL/6J
transcript	OTTMUST00000013307	VEGA | MGI Sequence Detail	1831	Not Applicable
polypeptide	OTTMUSP00000006163	VEGA | MGI Sequence Detail	345	Not Applicable

All sequences(44) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(2) : SNPs(44 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000004517	aurora kinase B

References

(Earliest) J:32112 Niwa H, et al., Cell-cycle-dependent expression of the STK-1 gene encoding a novel murine putative protein kinase. Gene. 1996 Mar 9;169(2):197-201
(Latest) J:191250 Izumiyama T, et al., A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis. Gene. 2012 Dec 15;511(2):202-17
All references(72)

Other accession IDs

MGD-MRK-35629, MGI:2141535