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Aurkb
Gene Detail
Symbol

Name
ID
Aurkb
aurora kinase B
MGI:107168
Synonyms
Aik2, AIRK2, aurora B, IPL1, STK-1, Stk12, Stk5
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:69045647-69051664 bp, + strand
From VEGA annotation of GRCm38

  6018 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55807  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AURKB
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Aurkb

Human
homologs
AURKB, aurora kinase B
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9212
neXtProt AC: NX_Q96GD4

Human Synonyms: AIK2, AIM1, AIM-1, ARK2, AurB, aurkb-sv1, aurkb-sv2, IPL1, PPP1R48, STK12, STK5

Human Chr (Location): 17p13.1; chr17:8204731-8210776 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(10) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Heterozygous null mice may develop oligospermia and show premature death and increased tumor incidence. Homozygous null embryos are small and die post-implantation showing reduced inner cell mass outgrowth, mitotic defects, aberrant trophoblast giant cells, edema, hemorrhage and increased apoptosis.
 
Interactions
Aurkb interacts with 128 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process cell cycle, cell division, ...
Component chromocenter, chromosome, ...
Function ATP binding, histone serine kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (171)    Tissues (154)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 109
Northern blot 2
RT-PCR 55
cDNA source data(100)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase aurkb    NEW 
Molecular
reagents
All nucleic(105) Genomic(1) cDNA(101) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000005961 (Evidence)
Ensembl Gene Model ENSMUSG00000020897 (Evidence)
Entrez Gene 20877 (Evidence)
UniGene 3488
DFCI TC1576436
DoTS DT.94146103, DT.101407594, DT.101159831, DT.94256776
NIA Mouse Gene Index U012804
EC 2.7.11.1
Consensus CDS Project CCDS24877.1
International Mouse Phenotyping Consortium Status Aurkb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005961 VEGA Gene Model | MGI Sequence Detail 6018 C57BL/6J ±  kb
transcript OTTMUST00000013307 VEGA | MGI Sequence Detail 1831 Not Applicable 
polypeptide OTTMUSP00000006163 VEGA | MGI Sequence Detail 345 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(91 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000004517 aurora kinase B
References
(Earliest) J:32112 Niwa H, et al., Cell-cycle-dependent expression of the STK-1 gene encoding a novel murine putative protein kinase. Gene. 1996 Mar 9;169(2):197-201
(Latest) J:211004 Balboula AZ, et al., Selective disruption of aurora C kinase reveals distinct functions from aurora B kinase during meiosis in mouse oocytes. PLoS Genet. 2014 Feb;10(2):e1004194
All references(77)
Other
accession IDs
MGD-MRK-35629, MGI:2141535

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory