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Aurkb
Gene Detail
 Symbol
Name
ID
Aurkb
aurora kinase B
MGI:107168
Synonyms Aik2, AIRK2, aurora B, IPL1, STK-1, Stk12, Stk5
Feature Type protein coding gene
Genetic Map
Chromosome 11
42.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:69045647-69051664 bp, + strand
From VEGA annotation of GRCm38

  6018 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55807  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Aurkb

Human
homologs
Human Homolog AURKB, aurora kinase B
NCBI Gene ID 9212
neXtProt AC  NX_Q96GD4
Human Synonyms  AIK2, AIM1, AIM-1, ARK2, AurB, aurkb-sv1, aurkb-sv2, IPL1, PPP1R48, STK12, STK5
Human Chr (Location)  17p13.1; chr17:8204731-8210626 (-)  GRCh38
Alleles
and
phenotypes
All alleles(18) : Gene trapped(10) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Heterozygous null mice may develop oligospermia and show premature death and increased tumor incidence. Homozygous null embryos are small and die post-implantation showing reduced inner cell mass outgrowth, mitotic defects, aberrant trophoblast giant cells, edema, hemorrhage and increased apoptosis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process cell cycle, cell division, ...
Component chromocenter, chromosome, ...
Function ATP binding, histone serine kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (166)    Tissues (152)    Images (22)
Theiler Stages: 13, 20, 22, 23, 24, 28
Assay TypeResults
RNA in situ 109
Northern blot 2
RT-PCR 55
cDNA source data(100)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(105) Genomic(1) cDNA(101) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005961 (Evidence)
Ensembl Gene ModelENSMUSG00000020897 (Evidence)
Entrez Gene20877 (Evidence)
UniGene3488
DFCITC1576436
DoTSDT.101159831, DT.101407594, DT.94146103, DT.94256776
NIA Mouse Gene IndexU012804
EC2.7.11.1
Consensus CDS ProjectCCDS24877.1
International Mouse Knockout Project StatusAurkb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005961 VEGA Gene Model | MGI Sequence Detail 6018 C57BL/6J ±  kb
transcript OTTMUST00000013307 VEGA | MGI Sequence Detail 1831 Not Applicable 
polypeptide OTTMUSP00000006163 VEGA | MGI Sequence Detail 345 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(4) UniProt(1)
Polymorphisms RFLP(2) : SNPs within 2kb(91 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000004517 aurora kinase B
References (Earliest) J:32112 Niwa H, et al., Cell-cycle-dependent expression of the STK-1 gene encoding a novel murine putative protein kinase. Gene. 1996 Mar 9;169(2):197-201
(Latest) J:206964 Wu X, et al., A novel function for Foxm1 in interkinetic nuclear migration in the developing telencephalon and anxiety-related behavior. J Neurosci. 2014 Jan 22;34(4):1510-22
All references(76)
Other
accession IDs
MGD-MRK-35629, MGI:2141535

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory