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Vipr2 Gene Detail
Summary
  • Symbol
    Vipr2
  • Name
    vasoactive intestinal peptide receptor 2
  • Synonyms
    Vip2, VIP receptor subtype 2, VPAC2, VPAC2R
  • Feature Type
    protein coding gene
  • IDs
    MGI:107166
    NCBI Gene: 22355
  • Gene Overview
    MyGene.info: VIPR2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:116077726-116146261 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      68536 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 62.59 cM, cytoband F2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    VIPR2, vasoactive intestinal peptide receptor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VIPR2, vasoactive intestinal peptide receptor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C16DUPq36.3, DUP7q36.3, PACAP-R3, PACAP-R-3, VIP-R-2, VPAC2, VPAC2R, VPCAP2R
  • Links
    NCBI Gene ID: 7434
    neXtProt AC: NX_P41587
    UniProt: P41587

  • Chr Location
    7q36.3; chr7:159028175-159144957 (-)  GRCh38.p7

Human Diseases
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  • References
    16 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    271 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit enhanced delayed-type hypersensitivity (type IV) and reduced immediate-type hypersensitivity (type I).
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000040123 VEGA Gene Model | MGI Sequence Detail 68536 C57BL/6J ±  kb
    transcript OTTMUST00000104256 VEGA | MGI Sequence Detail 3383 Not Applicable  
    polypeptide OTTMUSP00000058325 VEGA | MGI Sequence Detail 437 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      1592 from dbSNP Build 142
    Protein
    Information
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    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000017301 vasoactive intestinal polypeptide receptor 2
    • InterPro Domains
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR017981 GPCR, family 2-like
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
      IPR001571 GPCR, family 2, vasoactive intestinal peptide receptor
      IPR002284 GPCR, family 2, vasoactive intestinal peptide receptor 2
    Molecular
    Reagents
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    • All nucleic 21
      Genomic 1
      cDNA 17
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35627
    References
    more
    • Summaries
      All 315
      Developmental Gene Expression 13
      Diseases 16
      Gene Ontology 4
      Phenotypes 271
    • Earliest
      J:32788 Inagaki N, et al., Cloning and functional characterization of a third pituitary adenylate cyclase-activating polypeptide receptor subtype expressed in insulin-secreting cells. Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2679-83
    • Latest
      J:262939 Geiszler PC, et al., Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons. Sci Rep. 2018 Mar 19;8(1):4833

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory