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Vipr2 Gene Detail
Summary
  • Symbol
    Vipr2
  • Name
    vasoactive intestinal peptide receptor 2
  • Synonyms
    Vip2, VIP receptor subtype 2, VPAC2, VPAC2R
  • Feature Type
    protein coding gene
  • IDs
    MGI:107166
    NCBI Gene: 22355
  • Gene Overview
    MyGene.info: VIPR2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:116077726-116146261 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 62.59 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1592 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107166
protein coding gene Chr12:116077726-116148637 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020179
protein coding gene Chr12:118935803-119006806 (+)
A/J MGP_AJ_G0020135
protein coding gene Chr12:114591903-114661470 (+)
AKR/J MGP_AKRJ_G0020110
protein coding gene Chr12:118068678-118137475 (+)
BALB/cJ MGP_BALBcJ_G0020118
protein coding gene Chr12:115017111-115084157 (+)
C3H/HeJ MGP_C3HHeJ_G0019922
protein coding gene Chr12:118321983-118392749 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020565
protein coding gene Chr12:122687025-122753740 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018177
protein coding gene Chr12:110284663-110354466 (+)
CAST/EiJ MGP_CASTEiJ_G0019462
protein coding gene Chr12:112171459-112241709 (+)
CBA/J MGP_CBAJ_G0019889
protein coding gene Chr12:127559043-127633416 (+)
DBA/2J MGP_DBA2J_G0020006
protein coding gene Chr12:113954223-114022436 (+)
FVB/NJ MGP_FVBNJ_G0019991
protein coding gene Chr12:112639874-112709402 (+)
LP/J MGP_LPJ_G0020080
protein coding gene Chr12:118968286-119036426 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020027
protein coding gene Chr12:130865852-130934618 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020594
protein coding gene Chr12:117238877-117312158 (+)
PWK/PhJ MGP_PWKPhJ_G0019224
protein coding gene Chr12:108698879-108767392 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019029
protein coding gene Chr12:110157252-110224392 (+)
WSB/EiJ MGP_WSBEiJ_G0019520
protein coding gene Chr12:118184712-118253512 (+)



Homology
more
  • Human Ortholog
    VIPR2, vasoactive intestinal peptide receptor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VIPR2, vasoactive intestinal peptide receptor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C16DUPq36.3, DUP7q36.3, PACAP-R3, PACAP-R-3, VIP-R-2, VPAC2, VPAC2R, VPCAP2R
  • Links
    NCBI Gene ID: 7434
    neXtProt AC: NX_P41587
    UniProt: P41587

  • Chr Location
    7q36.3; chr7:159028175-159144957 (-)  GRCh38.p7

Human Diseases
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  • References
    16 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    283 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit enhanced delayed-type hypersensitivity (type IV) and reduced immediate-type hypersensitivity (type I).
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000011171 Ensembl Gene Model | MGI Sequence Detail 68536 C57BL/6J ±  kb
    transcript ENSMUST00000011315 Ensembl | MGI Sequence Detail 3383 Not Applicable  
    polypeptide ENSMUSP00000011315 Ensembl | MGI Sequence Detail 437 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000017301 vasoactive intestinal polypeptide receptor 2
    • InterPro Domains
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR017981 GPCR, family 2-like
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
      IPR001571 GPCR, family 2, vasoactive intestinal peptide receptor
      IPR002284 GPCR, family 2, vasoactive intestinal peptide receptor 2
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 17
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35627
    References
    more
    • Summaries
      All 329
      Developmental Gene Expression 14
      Diseases 16
      Gene Ontology 6
      Phenotypes 283
    • Earliest
      J:32788 Inagaki N, et al., Cloning and functional characterization of a third pituitary adenylate cyclase-activating polypeptide receptor subtype expressed in insulin-secreting cells. Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2679-83
    • Latest
      J:265370 Kukreja L, et al., Differential Neurotoxicity Related to Tetracycline Transactivator and TDP-43 Expression in Conditional TDP-43 Mouse Model of Frontotemporal Lobar Degeneration. J Neurosci. 2018 Jul 4;38(27):6045-6062

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory