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Hmx3
Gene Detail
 Symbol
Name
ID
Hmx3
H6 homeobox 3
MGI:107160
Synonyms Nkx5-1, Nkx5.1
Feature Type protein coding gene
Genetic Map
Chromosome 7
74.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:131542867-131544925 bp, + strand
From VEGA annotation of GRCm38

  2059 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40612  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Hmx3

Human
homologs
Human Homolog HMX3, H6 family homeobox 3
NCBI Gene ID 340784
neXtProt AC  NX_A6NHT5
Human Synonyms  Nkx5-1, NKX-5.1, NKX5.1
Human Chr (Location)  10q26.13; chr10:123136051-123137731 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit hyperactivity and circling behavior, and severe vestibular defects. Mutant females are infertile due to failure of implantation.
 
Interactions
Hmx3 interacts with 40 markers (Mir7-1, Mir7-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process brain development, cell differentiation, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (51 records)
Data Summary: Results (258)    Tissues (201)    Images (84)
Theiler Stages: 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 27, 28
Assay TypeResults
RNA in situ 228
In situ reporter (knock in) 26
RNase protection 4
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) Genomic(7) cDNA(12) Primer pair(1) Other(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037286 (Evidence)
Ensembl Gene ModelENSMUSG00000040148 (Evidence)
Entrez Gene15373 (Evidence)
UniGene323562
DFCITC1590168, TC1599408
DoTSDT.94333998, DT.97394936
Consensus CDS ProjectCCDS21917.1
International Mouse Knockout Project StatusHmx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037286 VEGA Gene Model | MGI Sequence Detail 2059 C57BL/6J ±  kb
transcript OTTMUST00000096191 VEGA | MGI Sequence Detail 1457 Not Applicable 
polypeptide OTTMUSP00000053714 VEGA | MGI Sequence Detail 356 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(9 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008648 homeobox protein HMX3
References (Earliest) J:17126 Bober E, et al., A novel NK-related mouse homeobox gene: expression in central and peripheral nervous structures during embryonic development. Dev Biol. 1994 Mar;162(1):288-303
(Latest) J:197180 Buniello A, et al., Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness. PLoS One. 2013;8(2):e56274
All references(82)
Other
accession IDs
MGD-MRK-12895, MGD-MRK-35621

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory