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Sin3b Gene Detail
Summary
  • Symbol
    Sin3b
  • Name
    transcriptional regulator, SIN3B (yeast)
  • Synonyms
    2810430C10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107158
    NCBI Gene: 20467
  • Gene Overview
    MyGene.info: SIN3B
Location & Maps
more
  • Sequence Map
    Chr8:72723288-72758203 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      34916 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 35.08 cM, cytoband C2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SIN3B, SIN3 transcription regulator family member B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SIN3B, SIN3 transcription regulator family member B
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 23309
    neXtProt AC: NX_O75182

  • Chr Location
    19p13.11; chr19:16829387-16880355 (+)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 81810
    1 human;1 mouse;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: SIN3B
  • Gene Tree
    Sin3b
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Targeted
    5
  • Genomic Mutations
    1 involving Sin3b
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Homozygous null mice fail to survive past P1 and exhibit pallor, fetal growth retardation, impaired terminal differentiation of erythrocytes and granulocytes, a pale liver and reduced ossification of the long bones in the hindlimb. Mutant MEFs show impaired G0 arrest upon serum deprivation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    186
  • Tissues
    180
  • cDNA Data
    177
  • Literature Summary
    13
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031622 Ensembl Gene Model | MGI Sequence Detail 34916 C57BL/6J ±  kb
transcript ENSMUST00000004494 Ensembl | MGI Sequence Detail 4117 Not Applicable  
polypeptide ENSMUSP00000004494 Ensembl | MGI Sequence Detail 1098 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    114 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 181
    Genomic 1
    cDNA 178
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-35619, MGI:1917199
References
more
  • Summaries
    All 54
    Developmental Gene Expression 13
    Gene Ontology 14
    Phenotypes 8
  • Earliest
    J:29949 Hurlin PJ, et al., Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J. 1995 Nov 15;14(22):5646-59
  • Latest
    J:220498 Garcia-Sanz P, et al., Sin3b interacts with Myc and decreases Myc levels. J Biol Chem. 2014 Aug 8;289(32):22221-36
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory