Sin3b
Gene Detail

Symbol

Name
ID

Sin3b
transcriptional regulator, SIN3B (yeast)
MGI:107158

Synonyms

2810430C10Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 8
35.08 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr8:72723288-72758203 bp, + strand From Ensembl annotation of GRCm38   34916 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:81810  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Sin3b

Human
homologs

Human Homolog		SIN3B, SIN3 transcription regulator family member B
NCBI Gene ID		23309
neXtProt AC		NX_O75182
Human Chr (Location)		19p13.11; chr19:16829398-16880355 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous null mice fail to survive past P1 and exhibit pallor, fetal growth retardation, impaired terminal differentiation of erythrocytes and granulocytes, a pale liver and reduced ossification of the long bones in the hindlimb. Mutant MEFs show impaired G0 arrest upon serum deprivation.

 

Interactions

Sin3b interacts with 129 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (32 annotations)

Process	cardiac muscle tissue development, histone deacetylation, ...
Component	autosome, cytoplasm, ...
Function	chromatin binding, histone deacetylase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (13 records)

Data Summary: Results (186)    Tissues (180)    Images (14)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	179
RT-PCR	7

cDNA source data(177)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(181) Genomic(1) cDNA(178) Primer pair(2)
Microarray probesets(6)

Other database
links

Ensembl Gene Model	ENSMUSG00000031622 (Evidence)
Entrez Gene	20467 (Evidence)
UniGene	2137
DFCI	TC1587369, TC1574354, TC1595425, TC1700785, TC1605872
DoTS	DT.101408936, DT.101408931, DT.99861001, DT.101408938, DT.94160201, DT.94134362, DT.536215
NIA Mouse Gene Index	U009501
PDB	2CZY, 1E91, 2F05, 2CR7, 1PD7
Consensus CDS Project	CCDS52598.1, CCDS52599.1
International Mouse Knockout Project Status	Sin3b

Sequences

Length	Strain/Species
genomic	ENSMUSG00000031622	Ensembl Gene Model | MGI Sequence Detail	34916	C57BL/6J
transcript	ENSMUST00000004494	Ensembl | MGI Sequence Detail	4117	Not Applicable
polypeptide	ENSMUSP00000004494	Ensembl | MGI Sequence Detail	1098	Not Applicable

All sequences(55) RefSeq(6) UniProt(5)

Polymorphisms

SNPs within 2kb(115 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR013194	Histone deacetylase interacting
InterPro	IPR003822	Paired amphipathic helix
Protein Ontology	PR:000014878	paired amphipathic helix protein Sin3b

References

(Earliest) J:29949 Hurlin PJ, et al., Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J. 1995 Nov 15;14(22):5646-59
(Latest) J:212766 Rielland M, et al., Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression. J Clin Invest. 2014 May 1;124(5):2125-35
All references(59)

Other
accession IDs

MGD-MRK-35619, MGI:1917199