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Sin3b Gene Detail
Summary
  • Symbol
    Sin3b
  • Name
    transcriptional regulator, SIN3B (yeast)
  • Synonyms
    2810430C10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107158
    NCBI Gene: 20467
  • Gene Overview
    MyGene.info: SIN3B
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:72723285-72758201 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 35.08 cM, cytoband C2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107158
protein coding gene Chr8:72723270-72758203 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033789
protein coding gene Chr8:73218195-73255978 (+)
A/J MGP_AJ_G0033771
protein coding gene Chr8:70239739-70275618 (+)
AKR/J MGP_AKRJ_G0033698
protein coding gene Chr8:72342357-72380272 (+)
BALB/cJ MGP_BALBcJ_G0033765
protein coding gene Chr8:70377213-70412788 (+)
C3H/HeJ MGP_C3HHeJ_G0033474
protein coding gene Chr8:72953185-72989850 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034285
protein coding gene Chr8:75978454-76019671 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031226
protein coding gene Chr8:64757113-64792770 (+)
CAST/EiJ MGP_CASTEiJ_G0032803
protein coding gene Chr8:72307411-72344783 (+)
CBA/J MGP_CBAJ_G0033453
protein coding gene Chr8:78700632-78741492 (+)
DBA/2J MGP_DBA2J_G0033607
protein coding gene Chr8:69986055-70021905 (+)
FVB/NJ MGP_FVBNJ_G0033552
protein coding gene Chr8:69068771-69104090 (+)
LP/J MGP_LPJ_G0033696
protein coding gene Chr8:73293724-73331411 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033596
protein coding gene Chr8:81172455-81207772 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034302
protein coding gene Chr8:72437840-72474039 (+)
PWK/PhJ MGP_PWKPhJ_G0032509
protein coding gene Chr8:69247917-69285445 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032347
protein coding gene Chr8:71321100-71355567 (+)
WSB/EiJ MGP_WSBEiJ_G0032918
protein coding gene Chr8:72697175-72736833 (+)



Homology
more
  • Human Ortholog
    SIN3B, SIN3 transcription regulator family member B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SIN3B, SIN3 transcription regulator family member B
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 23309
    neXtProt AC: NX_O75182
    UniProt: O75182

  • Chr Location
    19p13.11; chr19:16829387-16880355 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 81810
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SIN3B
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice fail to survive past P1 and exhibit pallor, fetal growth retardation, impaired terminal differentiation of erythrocytes and granulocytes, a pale liver and reduced ossification of the long bones in the hindlimb. Mutant MEFs show impaired G0 arrest upon serum deprivation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031622 Ensembl Gene Model | MGI Sequence Detail 34917 C57BL/6J ±  kb
    transcript ENSMUST00000004494 Ensembl | MGI Sequence Detail 4115 Not Applicable  
    polypeptide ENSMUSP00000004494 Ensembl | MGI Sequence Detail 1098 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 182
      Genomic 1
      cDNA 179
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-35619, MGI:1917199
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 14
      Gene Ontology 17
      Phenotypes 11
    • Earliest
      J:29949 Hurlin PJ, et al., Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J. 1995 Nov 15;14(22):5646-59
    • Latest
      J:252277 Langlet F, et al., Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling. Cell. 2017 Nov 02;171(4):824-835.e18

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory