Sin3b MGI Mouse Gene Detail - MGI:107158 - transcriptional regulator, SIN3B (yeast)

Sin3b Gene Detail

Symbol

Sin3b
Name

transcriptional regulator, SIN3B (yeast)
Synonyms

2810430C10Rik

Feature Type

protein coding gene
IDs

MGI:107158
NCBI Gene: 20467
Gene Overview

MyGene.info: SIN3B

Sequence Map

Chr8:72723285-72758201 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

34917 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 35.08 cM, cytoband C2
Mapping Data

4 experiments

Human Ortholog

SIN3B, SIN3 transcription regulator family member B

Vertebrate Orthologs

9

Human Ortholog

SIN3B, SIN3 transcription regulator family member B
Orthology source: HomoloGene, HGNC
Links

HGNC:19354

NCBI Gene ID: 23309

neXtProt AC: NX_O75182

UniProt: O75182
Chr Location

19p13.11; chr19:16829387-16880355 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 81810
1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SIN3B
Gene Tree

Sin3b

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Gene trapped

3
Targeted

5
Genomic Mutations

1 involving Sin3b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

24 strains or lines available

Homozygous null mice fail to survive past P1 and exhibit pallor, fetal growth retardation, impaired terminal differentiation of erythrocytes and granulocytes, a pale liver and reduced ossification of the long bones in the hindlimb. Mutant MEFs show impaired G0 arrest upon serum deprivation.

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All GO Annotations

33
GO References

17

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

186
Tissues

180
cDNA Data

177
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sin3b

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Sin3b interacts with 128 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

64
RefSeq

6
UniProt

6
CCDS

CCDS52598.1, CCDS52599.1
UniGene

2137

			Length	Strain/Species	Flank
genomic	OTTMUSG00000062065	VEGA Gene Model \| MGI Sequence Detail	34917	C57BL/6J	± kb
transcript	OTTMUST00000151547	VEGA \| MGI Sequence Detail	4115	Not Applicable
polypeptide	OTTMUSP00000078590	VEGA \| MGI Sequence Detail	1098	Not Applicable

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SNPs within 2kb

114 from dbSNP Build 142

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UniProt

6 Sequences
Protein Ontology

PR:000014878 paired amphipathic helix protein Sin3b

(term hierarchy)
PDB

1E91, 1PD7, 2CR7, 2CZY, 2F05
InterPro Domains

IPR013194 Histone deacetylase interacting domain

IPR003822 Paired amphipathic helix

IPR031693 Sin3, C-terminal

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All nucleic 181

Genomic 1

cDNA 178

Primer pair 2

Microarray probesets 6

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MGD-MRK-35619, MGI:1917199

Summaries

All 60

Developmental Gene Expression 13

Gene Ontology 17

Phenotypes 8
Earliest

J:29949 Hurlin PJ, et al., Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J. 1995 Nov 15;14(22):5646-59
Latest

J:240999 Mall M, et al., Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates. Nature. 2017 Apr 13;544(7649):245-249

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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