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Sin3b Gene Detail
Summary
  • Symbol
    Sin3b
  • Name
    transcriptional regulator, SIN3B (yeast)
  • Synonyms
    2810430C10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107158
    NCBI Gene: 20467
  • Gene Overview
    MyGene.info: SIN3B
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr8:72723285-72758201 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      34917 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 35.08 cM, cytoband C2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SIN3B, SIN3 transcription regulator family member B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SIN3B, SIN3 transcription regulator family member B
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 23309
    neXtProt AC: NX_O75182
    UniProt: O75182

  • Chr Location
    19p13.11; chr19:16829387-16880355 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 81810
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SIN3B
  • Gene Tree
    Sin3b
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice fail to survive past P1 and exhibit pallor, fetal growth retardation, impaired terminal differentiation of erythrocytes and granulocytes, a pale liver and reduced ossification of the long bones in the hindlimb. Mutant MEFs show impaired G0 arrest upon serum deprivation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    33
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    186
  • Tissues
    180
  • cDNA Data
    177
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000062065 VEGA Gene Model | MGI Sequence Detail 34917 C57BL/6J ±  kb
    transcript OTTMUST00000151547 VEGA | MGI Sequence Detail 4115 Not Applicable  
    polypeptide OTTMUSP00000078590 VEGA | MGI Sequence Detail 1098 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      114 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 181
      Genomic 1
      cDNA 178
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-35619, MGI:1917199
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 14
      Gene Ontology 17
      Phenotypes 9
    • Earliest
      J:29949 Hurlin PJ, et al., Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J. 1995 Nov 15;14(22):5646-59
    • Latest
      J:252277 Langlet F, et al., Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling. Cell. 2017 Nov 02;171(4):824-835.e18
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    06/12/2018
    MGI 6.12     		The Jackson Laboratory