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Sin3b
Gene Detail
Symbol

Name
ID
Sin3b
transcriptional regulator, SIN3B (yeast)
MGI:107158
Synonyms
2810430C10Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 8
35.08 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:72723288-72758203 bp, + strand
From Ensembl annotation of GRCm38

  34916 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81810  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Sin3b

Human
homologs
Human Homolog SIN3B, SIN3 transcription regulator family member B
NCBI Gene ID 23309
neXtProt AC  NX_O75182
Human Chr (Location)  19p13.11; chr19:16829398-16880355 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice fail to survive past P1 and exhibit pallor, fetal growth retardation, impaired terminal differentiation of erythrocytes and granulocytes, a pale liver and reduced ossification of the long bones in the hindlimb. Mutant MEFs show impaired G0 arrest upon serum deprivation.
 
Interactions
Sin3b interacts with 129 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cardiac muscle tissue development, histone deacetylation, ...
Component autosome, cytoplasm, ...
Function chromatin binding, histone deacetylase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (186)    Tissues (180)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 179
RT-PCR 7
cDNA source data(177)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(181) Genomic(1) cDNA(178) Primer pair(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000031622 (Evidence)
Entrez Gene20467 (Evidence)
UniGene2137
DFCITC1605872, TC1595425, TC1574354, TC1587369, TC1700785
DoTSDT.101408936, DT.99861001, DT.101408931, DT.101408938, DT.94160201, DT.94134362, DT.536215
NIA Mouse Gene IndexU009501
PDB2CZY, 1E91, 2F05, 2CR7, 1PD7
Consensus CDS ProjectCCDS52598.1, CCDS52599.1
International Mouse Knockout Project StatusSin3b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031622 Ensembl Gene Model | MGI Sequence Detail 34916 C57BL/6J ±  kb
transcript ENSMUST00000004494 Ensembl | MGI Sequence Detail 4117 Not Applicable 
polypeptide ENSMUSP00000004494 Ensembl | MGI Sequence Detail 1098 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(6) UniProt(9)
Polymorphisms
SNPs within 2kb(115 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013194 Histone deacetylase interacting
InterPro IPR003822 Paired amphipathic helix
Protein Ontology PR:000014878 paired amphipathic helix protein Sin3b
References
(Earliest) J:29949 Hurlin PJ, et al., Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J. 1995 Nov 15;14(22):5646-59
(Latest) J:212766 Rielland M, et al., Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression. J Clin Invest. 2014 May 1;124(5):2125-35
All references(59)
Other
accession IDs
MGD-MRK-35619, MGI:1917199

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory