Sin3b MGI Mouse Gene Detail - MGI:107158 - transcriptional regulator, SIN3B (yeast)

Symbol

Sin3b
Name

transcriptional regulator, SIN3B (yeast)
Synonyms

2810430C10Rik

Feature Type

protein coding gene
IDs

MGI:107158
NCBI Gene: 20467
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:73449913-73484829 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 35.08 cM, cytoband C2
Mapping Data

4 experiments

SNPs within 2kb

113 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107158	protein coding gene	Chr8:73449898-73484831 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033789	protein coding gene	Chr8:73218195-73255978 (+)
A/J	MGP_AJ_G0033771	protein coding gene	Chr8:70239739-70275618 (+)
AKR/J	MGP_AKRJ_G0033698	protein coding gene	Chr8:72342357-72380272 (+)
BALB/cJ	MGP_BALBcJ_G0033765	protein coding gene	Chr8:70377213-70412788 (+)
C3H/HeJ	MGP_C3HHeJ_G0033474	protein coding gene	Chr8:72953185-72989850 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034285	protein coding gene	Chr8:75978454-76019671 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031226	protein coding gene	Chr8:64757113-64792770 (+)
CAST/EiJ	MGP_CASTEiJ_G0032803	protein coding gene	Chr8:72307411-72344783 (+)
CBA/J	MGP_CBAJ_G0033453	protein coding gene	Chr8:78700632-78741492 (+)
DBA/2J	MGP_DBA2J_G0033607	protein coding gene	Chr8:69986055-70021905 (+)
FVB/NJ	MGP_FVBNJ_G0033552	protein coding gene	Chr8:69068771-69104090 (+)
LP/J	MGP_LPJ_G0033696	protein coding gene	Chr8:73293724-73331411 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033596	protein coding gene	Chr8:81172455-81207772 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034302	protein coding gene	Chr8:72437840-72474039 (+)
PWK/PhJ	MGP_PWKPhJ_G0032509	protein coding gene	Chr8:69247917-69285445 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032347	protein coding gene	Chr8:71321100-71355567 (+)
WSB/EiJ	MGP_WSBEiJ_G0032918	protein coding gene	Chr8:72697175-72736833 (+)

Human Ortholog

SIN3B, SIN3 transcription regulator family member B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SIN3B, SIN3 transcription regulator family member B
Links

HGNC:19354

NCBI Gene ID: 23309

neXtProt AC: NX_O75182

UniProt: O75182
Chr Location

19p13.11; chr19:16829387-16880355 (+) GRCh38.p7

Alliance of Genome Resources

Sin3b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SIN3B
Gene Tree

Sin3b

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Gene trapped

3
Targeted

5
Genomic Mutations

1 involving Sin3b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice fail to survive past P1 and exhibit pallor, fetal growth retardation, impaired terminal differentiation of erythrocytes and granulocytes, a pale liver and reduced ossification of the long bones in the hindlimb. Mutant MEFs show impaired G0 arrest upon serum deprivation.

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All GO Annotations

37
GO References

19

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

859
Tissues

180
cDNA Data

178
Literature Summary

17

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sin3b

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Sin3b interacts with 128 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

69
RefSeq

6
UniProt

6
CCDS

CCDS52598.1, CCDS52599.1

Ensembl

ENSMUSG00000031622 (Evidence)
NCBI Gene

20467

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031622	Ensembl Gene Model \| MGI Sequence Detail	34917	C57BL/6J	± kb
transcript	ENSMUST00000004494	Ensembl \| MGI Sequence Detail	4115	Not Applicable
polypeptide	ENSMUSP00000004494	Ensembl \| MGI Sequence Detail	1098	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000014878 paired amphipathic helix protein Sin3b

(term hierarchy)
PDB

1E91, 1PD7, 2CR7, 2CZY, 2F05, 5Y95
InterPro Domains

IPR013194 Histone deacetylase interacting domain

IPR003822 Paired amphipathic helix

IPR036600 Paired amphipathic helix superfamily

IPR031693 Sin3, C-terminal

IPR039774 Transcriptional regulatory protein Sin3-like

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All nucleic 182

Genomic 1

cDNA 179

Primer pair 2

Microarray probesets 6

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MGD-MRK-35619, MGI:1917199

Summaries

All 74

Developmental Gene Expression 17

Gene Ontology 19

Phenotypes 13
Earliest

J:29949 Hurlin PJ, et al., Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J. 1995 Nov 15;14(22):5646-59
Latest

J:293336 Yang X, et al., Coregulator Sin3a Promotes Postnatal Murine beta-Cell Fitness by Regulating Genes in Ca(2+) Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response. Diabetes. 2020 Jun;69(6):1219-1231

TSS for Sin3b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78016	Chr8:73449909-73449921 (+)	2 bp
Tssr78017	Chr8:73452228-73452249 (+)	2,326 bp
Tssr78018	Chr8:73468352-73468365 (+)	18,446 bp
Tssr78019	Chr8:73468428-73468436 (+)	18,519 bp
Tssr78020	Chr8:73468491-73468504 (+)	18,585 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 08/03/2022 MGI 6.21